Novel nanocomposite hydrogel for wound dressing and other medical applications

RSC Advances ◽  
2015 ◽  
Vol 5 (125) ◽  
pp. 103036-103046 ◽  
Author(s):  
Ali Hebeish ◽  
S. Sharaf
Keyword(s):  
Carboxymethyl Cellulose ◽  
Wound Dressing ◽  
Graft Copolymerization ◽  
Crosslinking Agent ◽  
Water Soluble ◽  
Medical Applications ◽  
Nanocomposite Hydrogel ◽  
Hydrogel Nanocomposites

Graft copolymerization of DADMAC with a MBA crosslinking agent was achieved on water soluble carboxymethyl cellulose with an APS initiator. A CuO nanocomposite hydrogel was formed in situ on cotton. The synthesis of Ag/CMC-DADMAC hydrogel nanocomposites was also studied.

In vitro biocompatibility evaluation of radiolytically synthesized silver/polyvinyl hydrogel nanocomposites for wound dressing applications

2020 ◽  
Vol 35 (4-5) ◽  
pp. 435-450
Author(s):  
Swaroop Kumaraswamy ◽  
Shrikant L Patil ◽  
Somashekarappa H Mallaiah
Keyword(s):  
Polyvinyl Alcohol ◽  
Gamma Irradiation ◽  
Wound Dressing ◽  
Wound Care ◽  
Crosslinking Agent ◽  
Homogeneous Distribution ◽  
Swelling Properties ◽  
In Vitro Biocompatibility ◽  
Hydrogel Nanocomposites

Nano silver/polyvinyl alcohol hydrogel nanocomposites have been prepared using gamma irradiation technique. Gamma irradiation serves as a crosslinking agent for the polyvinyl alcohol hydrogels and also acts as a reducing agent for reduction of Ag+ ions to zero valent Ag0 within the polyvinyl alcohol crosslinked network. The microstructural characteristics of the prepared composites were studied using powder X-ray diffraction, ultraviolet–visible spectroscopy, Fourier-transform infrared spectroscopy and field emission scanning electron microscopy analysis. The data obtained by these characterizations indicate the homogeneous distribution of silver nanoparticles on the polyvinyl alcohol network. The swelling properties and mechanical parameters of the silver/polyvinyl alcohol hydrogel nanocomposites tend to show improvements, making them a better material for wound care applications. The silver/polyvinyl alcohol hydrogel nanocomposites have shown good antibacterial potential against both Gram-positive and Gram-negative bacteria and shown nil or minimal cytotoxic effect on human melanoma (SK-MEL-2) and mouse melanoma (B16-F1) cell lines. Overall, it was concluded that under optimized condition, silver/polyvinyl alcohol hydrogel nanocomposites synthesized using gamma irradiation technique are excellent candidates for wound dressing application.

scholarly journals Corn starch reactive blending with latex from natural rubber using Na+ ions augmented carboxymethyl cellulose as a crosslinking agent

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Noppol Leksawasdi ◽  
Thanongsak Chaiyaso ◽  
Pornchai Rachtanapun ◽  
Sarinthip Thanakkasaranee ◽  
Pensak Jantrawut ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Natural Rubber ◽  
Carboxymethyl Cellulose ◽  
Corn Starch ◽  
Crosslinking Agent ◽  
Medical Applications ◽  
Reactive Blending ◽  
Swelling Properties ◽  
Elongation At Break ◽  
Na Ions

AbstractA mixture of corn starch and glycerol plasticizer (CSG) was blended with latex natural rubber (LNR) and carboxymethyl cellulose (CMC). The addition of 10 phr of CMC improved the Young’s modulus (6.7 MPa), tensile strength (8 MPa), and elongation at break (80%) of the CSG/LNR blend. The morphology of the CSG/LNR/CMC blends showed a uniform distribution of LNR particles (1–3 µm) in the CSG matrix. The addition of CMC enhanced the swelling ability and water droplet contact angle of the blends owing to the swelling properties, interfacial crosslinking, and amphiphilic structure of CMC. Fourier transform infrared spectroscopy confirmed the reaction between the C=C bond of LNR and the carboxyl groups (–COO−) of CMC, in which the Na+ ions in CMC acted as a catalyst. Notably, the mechanical properties of the CSG/LNR/CMC blend were improved owing to the miscibility of CSG/CMC and the CMC/LNR interfacial reaction. The CSG/LNR/CMC biodegradable polymer with high mechanical properties and interfacial tension can be used for packaging, agriculture, and medical applications.

Hybrid Gelatin/Carboxymethyl Cellulose Hydrogel Loaded Copper (II) Ion for Medical Applications

2020 ◽  
Vol 1009 ◽  
pp. 3-8
Author(s):  
Narumol Kreua-Ongarjnukool ◽  
Saowapa Thumsing Niyomthai ◽  
Kodchaporn Sarodom ◽  
Thitithip Lothong ◽  
Nopparuj Soomherun
Keyword(s):  
Escherichia Coli ◽  
Carboxymethyl Cellulose ◽  
Wound Dressing ◽  
Suitable Condition ◽  
Medical Applications ◽  
Solvent Casting ◽  
Zone Of Inhibition ◽  
Surgical Wounds ◽  
Cellulose Hydrogel ◽  
Domestic Medical

Antibacterial wound dressing has an important key in an infection in traumatic and surgical wounds. However, the antibacterial wound dressing is high cost and few domestic medical productions. The aim of this study is to prepare a wound dressing hydrogel from hybrid gelatin/carboxymethyl cellulose (Gel/CMC) hydrogel crosslinked with citric acid at different Gel: CMC ratios of 1:1, 1:2, 1:3, and 1:4 by solvent casting. The gel fractions and swelling of 6.0%w/v CuSO4 loading hybrid Gel/CMC hydrogel (Cu-Gel/CMC hydrogel) were a maximum of about 44% to 53% and 85% to 245%, respectively. The results showed that the 1:1 Gel: CMC of hydrogel produce was the most suitable condition due to its good gel fractions and swelling behavior. The cumulative Cu2+ release was a maximum of about 45% in 7 days. The hybrid Cu-Gel/CMC hydrogel showed the zone of inhibition of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) about 16 mm and 19 mm, sequentially. The research provided that the hybrid Cu-Gel/CMC hydrogel has the potential to use in medical applications.

Design and Preparation of a Bioresponsive Hydrogel for Biomedical Application as a Wound Dressing

2008 ◽  
Vol 55-57 ◽  
pp. 681-684 ◽  
Author(s):  
C. Witthayaprapakorn ◽  
Robert Molloy ◽  
K. Nalampang ◽  
B.J. Tighe
Keyword(s):  
Aqueous Solution ◽  
Wound Dressing ◽  
Biomedical Application ◽  
Transmission Rate ◽  
Crosslinking Agent ◽  
Sheet Thickness ◽  
Ambient Air ◽  
Water Soluble ◽  
Parallel Plates ◽  
Good Transparency

In this work, the sodium salt of 2-acrylamido-2-methylpropanesulfonic acid (Na-AMPS) was photopolymerised in aqueous solution with ethylene glycol dimethacrylate (EGDM) added as a crosslinking agent and 4,4'-azo-bis(4-cyanopentanoic acid) as the water-soluble photoinitiator. The aqueous solution was poured into a vertical sheet-forming mould consisting of two parallel plates covered with Teflon® sheets as release liners. Spacers were used to control the sheet thickness with a polymer mesh inserted in the middle to strengthen the hydrogel. The hydrogel sheets obtained were of 1.2 ± 0.2 mm thickness and showed good transparency, flexibility and skin adhesion. On immersion in distilled water at 37°C, it was found that the equilibrium water content (EWC) reached 98 ± 1% within 20 mins following which the equilibrium water retention (EWR) in ambient air was 21 ± 1% over a period of about 4 hrs. The water vapour transmission rate (WVTR) was measured at 37 °C and was found to be 82 ± 2 g m-2 hr-1. It is concluded that this Na-AMPS hydrogel sheet has properties which show potential for biomedical use as a wound dressing.

Development of In Situ-Formed Interconnected Porous Scaffolds with Low Porosity

2007 ◽  
Vol 361-363 ◽  
pp. 415-418
Author(s):  
Yu Lin Li ◽  
Masanori Kikuchi
Keyword(s):  
Tensile Strength ◽  
Ultimate Tensile Strength ◽  
Polymethyl Methacrylate ◽  
Carboxymethyl Cellulose ◽  
Water Soluble ◽  
Wet Spinning ◽  
Porous Scaffolds ◽  
Volume Percent ◽  
Kneading Method

Biocompatible and water-soluble fibers (sodium carboxymethyl cellulose (CMC)) were fabricated via a wet-spinning method. The CMC fibers/ polymethyl methacrylate (PMMA) mixtures and CMC fibers/Poly (L-lactide-co-glycolide-co- -caprolactone) (PLGC) mixtures were prepared by a heat-kneading method. For CMC fibers/PMMA, after removal of the CMC fibers from the mixtures, the interconnected porous scaffolds with porosity from 27.79 % to 60.98 % (volume percent) were obtained. For CMC fibers/PLGC, the interconnected porous scaffolds with porosity 38.55 % and 76.83 % (volume percent) were prepared. The solid CMC fibers/PLGC mixtures had the higher ultimate tensile strength and Young, s modulus than those of porous PLGC scaffolds.

Development of sodium carboxymethyl cellulose based polymeric microparticles for in situ hydrogel wound dressing formation

2021 ◽  
Vol 602 ◽  
pp. 120606
Author(s):  
Cinzia Pagano ◽  
Paola Calarco ◽  
Alessandro Di Michele ◽  
Maria Rachele Ceccarini ◽  
Tommaso Beccari ◽  
...  
Keyword(s):  
Carboxymethyl Cellulose ◽  
Wound Dressing ◽  
Sodium Carboxymethyl Cellulose ◽  
In Situ Hydrogel ◽  
Polymeric Microparticles

Investigation of Dialdehyde Corn Starch as Crosslinking Agent in Collagen-Based Wound Dressing Materials

2016 ◽  
Author(s):  
Cigdem Kilicarislan Ozkan ◽  
Hasan Ozgunay ◽  
Stefania Marin ◽  
Madalina Georgiana Albu Kaya
Keyword(s):  
Wound Dressing ◽  
Corn Starch ◽  
Crosslinking Agent ◽  
Dressing Materials ◽  
Wound Dressing Materials
Sign in / Sign up

Export Citation Format

Share Document