Surface charge-reversible polyelectrolyte complex nanoparticles for hepatoma-targeting delivery of doxorubicin

2015 ◽  
Vol 3 (30) ◽  
pp. 6185-6193 ◽  
Author(s):  
Xubo Zhao ◽  
Peng Liu ◽  
Qilei Song ◽  
Nan Gong ◽  
Liangwei Yang ◽  
...  
Keyword(s):  
Drug Release ◽  
Surface Charge ◽  
Polyelectrolyte Complex ◽  
Polymeric Nanoparticles ◽  
Controlled Drug Release ◽  
Targeting Delivery

Polymeric nanoparticles are greatly advancing the field of nanomedicine due to their ability for targeted and controlled drug release.

Synthesis of thermo-sensitive polyelectrolyte complex nanoparticles from CS-g-PNIPAM and SA-g-PNIPAM for controlled drug release

2014 ◽  
Vol 22 (9) ◽  
pp. 1004-1011 ◽  
Author(s):  
Minyi Qi ◽  
Guiying Li ◽  
Nana Yu ◽  
Yanfeng Meng ◽  
Xunyong Liu
Keyword(s):  
Drug Release ◽  
Polyelectrolyte Complex ◽  
Controlled Drug Release

scholarly journals DESIGN AND EVALUATION OF FLUTAMIDE-LOADED POLYCAPROLACTONE NANOPARTICLES BY 23 FACTORIAL DESIGN AND NANOPRECIPITATION METHOD

2018 ◽  
Vol 11 ◽  
Author(s):  
Venkateswara Rao S
Keyword(s):  
Drug Release ◽  
Polymeric Nanoparticles ◽  
In Vitro Release ◽  
Kinetic Equations ◽  
Storage Conditions ◽  
23 Factorial Design ◽  
Accelerated Storage ◽  
Nanoprecipitation Method ◽  
Targeting Delivery

Objective: The present work was aimed to prepare and evaluate polymeric nanoparticles (NPs) of flutamide by nanoprecipitation method and factorial. The influences of various formulation components such as polymer, organic phase volume, and surfactant on the characteristics of NPs were investigated.Methods: The polycaprolactone (PCL) loaded with drug was evaluated for surface morphology, surface charge, particles size, encapsulation efficiency, drug content, and in vitro release studies. Fourier transform infrared studies were indicated no interaction between the drug and polymer.Results: The results of the drug release study of NPs may fit with different kinetic equations. The particle size varied from 128 to 317 nm and zeta potential was in negative and its value found to be - 46.4 mv. The content of flutamide was found in between 74%±0.72 to 92%±0.53 in flutamide loaded PCL NPs. The minimum and maximum entrapment efficiencies were found to be of 75%±0.66 and 92%±0.70. The percentage yields of all formulations were in the range of 46.05%±1.56–86.78%±1.32. The in vitro drug release followed zero order with sustained behavior for a period of 24 h. Results of accelerated storage conditions of optimized formulation revealed that no significant changes in formulation F2.Conclusion: The present investigation opens new frontiers in developing flutamide NPs for targeting delivery to the prostate for the prostate cancer treatment which also overcome the problems associated with conventional formulations such as multiple-dose therapy, poor patient compliance, and high treatment cost.

scholarly journals Targeted, Monitored, and Controlled Chemotherapy: A Multimodal Nanotechnology-Based Approach against Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Ali Shakeri-Zadeh ◽  
Samideh Khoei ◽  
Sepideh Khoee ◽  
Ali Mohammad Sharifi ◽  
Mohammad-Bagher Shiran
Keyword(s):  
Drug Release ◽  
Anticancer Drugs ◽  
Polymeric Nanoparticles ◽  
Control Release ◽  
Controlled Drug Release ◽  
Drug Carriers ◽  
Chemotherapeutic Agents ◽  
Drug Uptake ◽  
Cancerous Cell ◽  
Cancer Tumor

We review innovative methods for treatment of cancer tumor on the basis of nanotechnology and physics to target, monitor and control release of chemotherapeutic agents. Chemotherapy is one of the main methods of treatment for cancer and plays a vital role in clinical practice, but side effects of anticancer drugs are still critical problems. Magnetic nanoparticles can be applied as an effective drug carriers and contrast agents for magnetic resonance imaging (MRI). Since certain nanoparticles have magnetic properties, they can be trapped in tumor during blood circulation by an external magnetic field. Also, polymeric nanoparticles are great candidates to encapsulate anticancer drugs and to control the release profile of drugs in biologic media. We suggest the construction of drug-loaded polymer-coated magnetic (DPM) nanoplatform with the potential for being utilized in medical imaging as well as having controlled drug release properties. Nanoplatform distribution can be monitored by MRI and with clever combination of ultrasound physics and suggested DPM nanoplatform, it would be feasible to increase the rate of drug release (in situ) and drug uptake by cancerous cell. To optimize the level of drug uptake by cancerous cell, the selection of ultrasound frequency and intensity is essential. The development of suggested method could be a new approach against cancer tumor.

scholarly journals Surfactant Mediated Synthesis of Polyhydroxybutyrate (PHB) Nanoparticles for Sustained Drug Delivery

2020 ◽  
Vol 2 (1) ◽  
pp. 41
Keyword(s):  
Drug Release ◽  
Functional Group ◽  
Antibacterial Effect ◽  
Polymeric Nanoparticles ◽  
Controlled Drug Release ◽  
Sustained Drug Release ◽  
Bacterial Fermentation ◽  
Sustained Drug Delivery ◽  
Nanoprecipitation Method ◽  
Living Organisms

Polyhydroxyalkanoates are produced by bacterial fermentation that contains ester as their functional group. Polymeric substances derived from living organisms are captivating owing to the fact of their adaptability, biocompatibility, and biodegradability. The main objective of this study is to develop polymeric nanoparticles through the nanoprecipitation method using the PHA extracted from Pseudomonas aeruginosa. In this study, PHA extracted was characterized and determined as Polyhydroxybutyrate. The PHA was further used to produce nanoparticles by nanoprecipitation method using Dichloromethane as a solvent and subjected to various characterizations such as Ultraviolet-Visible spectroscopy (UV-Vis), Fourier Infra-Red spectroscopy (FTIR), Field Emission Scanning Electron microscopy (FeSEM) and further tested for sustained drug release. Nanoparticles prepared by the nanoprecipitation method had a size with invariable dissemination. Curcumin loaded PHA nanoparticles displayed a competent antibacterial effect against Bacillus subtilis. A controlled drug release was exhibited.

scholarly journals Diosgenin Loaded Polymeric Nanoparticles with Potential Anticancer Efficacy

Biomolecules ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 1679
Author(s):  
Nikita Sharma ◽  
Monisha Singhal ◽  
R. Mankamna Kumari ◽  
Nidhi Gupta ◽  
Romila Manchanda ◽  
...  
Keyword(s):  
Drug Release ◽  
Cell Lines ◽  
Polymeric Nanoparticles ◽  
Entrapment Efficiency ◽  
Controlled Drug Release ◽  
Anticancer Efficacy ◽  
Model Cell ◽  
A549 Lung Carcinoma Cell ◽  
Cytotoxic Studies

This study aims to determine the anticancer efficacy of diosgenin encapsulated poly-glycerol malate co-dodecanedioate (PGMD) nanoparticles. Diosgenin loaded PGMD nanoparticles (variants 7:3 and 6:4) were synthesized by the nanoprecipitation method. The synthesis of PGMD nanoparticles was systematically optimized employing the Box-Behnken design and taking into account the influence of various independent variables such as concentrations of each PGMD, diosgenin and PF-68 on the responses such as size and PDI of the particles. Mathematical modeling was done using the Quadratic second order modeling method and response surface analysis was undertaken to elucidate the factor-response relationship. The obtained size of PGMD 7:3 and PGMD 6:4 nanoparticles were 133.6 nm and 121.4 nm, respectively, as measured through dynamic light scattering (DLS). The entrapment efficiency was in the range of 77–83%. The in vitro drug release studies showed diffusion and dissolution controlled drug release pattern following Korsmeyer–Peppas kinetic model. Furthermore, in vitro morphological and cytotoxic studies were performed to evaluate the toxicity of synthesized drug loaded nanoparticles in model cell lines. The IC50 after 48 h was observed to be 27.14 µM, 15.15 µM and 13.91 µM for free diosgenin, PGMD 7:3 and PGMD 6:4 nanoparticles, respectively, when administered in A549 lung carcinoma cell lines.

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