NO-Responsive vesicles as a drug delivery system

2017 ◽  
Vol 53 (25) ◽  
pp. 3535-3538 ◽  
Author(s):  
Zhi-Heng Li ◽  
Zheng-Li Tan ◽  
Ai-Xiang Ding ◽  
Bing Gong ◽  
Zhong-Lin Lu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Aqueous Solution ◽  
Drug Delivery System ◽  
Delivery System ◽  
Living Cells ◽  
System P ◽  
Model Drug ◽  
And Control

A NO-response amphiphile was successfully formed into vesicles in aqueous solution, which could encapsulate and control the release of carboxyfluorescein (CF) as a model drug in vitro and in living cells.

scholarly journals Development and in vitro Evaluation of Gastro-protective Aceclofenac-loaded Self-emulsifying Drug Delivery System

2020 ◽  
Vol Volume 15 ◽  
pp. 5217-5226 ◽  
Author(s):  
Chen Jianxian ◽  
Kalsoom Saleem ◽  
Muhammad Ijaz ◽  
Masood Ur-Rehman ◽  
Ghulam Murtaza ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Evaluation ◽  
System P

Development of a microdevice-based human mesenchymal stem cell-mediated drug delivery system

2019 ◽  
Vol 7 (6) ◽  
pp. 2348-2357 ◽  
Author(s):  
Junfei Xia ◽  
Ang-Chen Tsai ◽  
Wenhao Cheng ◽  
Xuegang Yuan ◽  
Teng Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Human Mesenchymal Stem Cell ◽  
Living Cells ◽  
Controlled Delivery ◽  
System P

Cell-mediated drug delivery systems utilize living cells as vehicles to achieve controlled delivery of drugs.

Ginsenoside nanoparticle: a new green drug delivery system

2016 ◽  
Vol 4 (3) ◽  
pp. 529-538 ◽  
Author(s):  
Lin Dai ◽  
Kefeng Liu ◽  
Chuanling Si ◽  
Luying Wang ◽  
Jing Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Ginsenoside Rb1 ◽  
Anticancer Effects ◽  
System P

Ginsenoside Rb1 is shown to self-assemble with anticancer drugs to form stable nanoparticles, which have greater anticancer effectsin vitroandin vivothan the free drugs.

scholarly journals Folic Acid-Functionalized Black Phosphorus Quantum Dots for Targeted Chemo-Photothermal Combination Cancer Therapy

Pharmaceutics ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 242 ◽  
Author(s):  
Miaomiao Luo ◽  
Wei Cheng ◽  
Xiaowei Zeng ◽  
Lin Mei ◽  
Gan Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Folic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Black Phosphorus ◽  
Model Drug ◽  
Black Phosphorus Quantum Dots

Due to the inherent limitations, single chemo or photothermal therapies (PTT) are always inefficient. The combination of chemotherapy and PTT for the treatment of cancers has attracted a great interest during the past few years. As a photothermal agent, black phosphorus quantum dots (BPQDs) possess an excellent extinction coefficient, high photothermal conversion efficacy, and good biocompatibility. Herein, we developed a photo- and pH-sensitive nanoparticle based on BPQDs for targeted chemo-photothermal therapy. Doxorubicin (DOX) was employed as a model drug. This nanosystem displayed outstanding photothermal performance both in vitro and in vivo. Folic acid conjugation onto the surface endowed this system an excellent tumor-targeting effect, which was demonstrated by the cellular targeting assay. The BPQDs-based drug delivery system exhibited pH- and photo-responsive release properties, which could reduce the potential damage to normal cells. The in vitro cell viability study showed a synergistic effect in suppressing cancer cell proliferation. Therefore, this BPQDs-based drug delivery system has substantial potential for future clinical applications.

scholarly journals Red-Light Triggered Photouncaging from Dicyanomethylene-4H-pyran Phototrigger in Aqueous Solution: Applied as a Single Component Nano-Drug Delivery System for Cancer Therapy

2021 ◽  
Author(s):  
Biswajit Roy ◽  
Rakesh Mengji ◽  
Moumita Kundu ◽  
Sujit Ghosh ◽  
Mahitosh Mondal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Aqueous Solution ◽  
Valproic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Red Light ◽  
Single Component ◽  
Photoremovable Protecting Groups ◽  
Aliphatic Carboxylic Acids

The development of Photoremovable protecting groups (PRPGs), which can be activated in the ʽphototherapeutic windowʼ for biological applications, is highly challenging. Only PRPGs based on BODIPY dye have been developed so far, which can be excited ≥600 nm. Herein, we developed for the first time NIR dye hydroxystyryl dicyanomethylene-4H-pyran (DCM) as a PRPG that can be operated in the phototherapeutic window. Ours easily synthesized DCM photocages efficiently released aromatic and aliphatic carboxylic acids in an aqueous solution on irradiation using the light of wavelength ≥600 nm and 650 nm, separately. As an application, we used our DCM-PRPG as a single component nanocarrier drug delivery system (DDS) to uncage valproic acid (a known histone deacetylase inhibitor) for cancer treatment. In vitro studies revealed that our DDS, hydroxystyryl dicyanomethylene-4H-pyran valproic acid conjugate nanoparticles (DCM-VPA-NPs) exhibited good cellular internalization, biocompatibility, and enhanced cytotoxicity upon irradiation.

In vitro and in vivo photothermally enhanced chemotherapy by single-walled carbon nanohorns as a drug delivery system

2014 ◽  
Vol 2 (29) ◽  
pp. 4726-4732 ◽  
Author(s):  
Daiqin Chen ◽  
Chao Wang ◽  
Feng Jiang ◽  
Zhuang Liu ◽  
Chunying Shu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Biomedical Applications ◽  
Carbon Nanohorns ◽  
Single Walled Carbon ◽  
System P

Single-walled carbon nanohorns (SWNHs) have exhibited many special advantages in biomedical applications.

scholarly journals Correction: In vitro drug controlled-release behavior of an electrospun modified poly(lactic acid)/bacitracin drug delivery system

RSC Advances ◽  
2016 ◽  
Vol 6 (5) ◽  
pp. 3623-3623
Author(s):  
Junyan Yao ◽  
Shijie Zhang ◽  
Wudan Li ◽  
Zhi Du ◽  
Yujie Li
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Poly Lactic Acid ◽  
Release Behavior ◽  
Drug Controlled Release ◽  
System P

Correction for ‘In vitro drug controlled-release behavior of an electrospun modified poly(lactic acid)/bacitracin drug delivery system’ by Junyan Yao et al., RSC Adv., 2016, 6, 515–521.

Electrospun MWCNTs/Poly(lactic-co-glycolic acid) Composite Nanofibrous Drug Delivery System

2012 ◽  
Vol 424-425 ◽  
pp. 1220-1223 ◽  
Author(s):  
Rui Ling Qi ◽  
Hui Juan Liu
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Carriers ◽  
Mouse Fibroblast ◽  
Burst Release ◽  
Vis Spectroscopy ◽  
Multi Walled Carbon Nanotubes ◽  
Model Drug

In this study, nanotubular materials multi-walled carbon nanotubes (MWCNTs) were used to encapsulate a model drug, doxorubicine hydrochloride (DOX). Then, the drug-loaded nanotubes (DOX/CNTs) with an optimized drug encapsulation percentage were mixed with poly (lactide-co-glycolide) (PLGA) polymer solution for subsequent electrospinning to form drug-loaded composite nanofibrous mats. The morphology was characterized using scanning electron microscopy (SEM). The proliferation of mouse fibroblast cells cultured on both PLGA and CNTs-doped PLGA fibrous scaffolds were compared through 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyl tetrazolium bromide (MTT) assay of cell viability and SEM observation of cell morphology. In vitro drug release behavior was examined using UV-vis spectroscopy. We show that the incorporation of CNTs and DOX/CNTs within the nanofibrous mats does not significantly change the morphology of the mats. In addition, our results indicate that this double-container drug delivery system (both PLGA polymer and CNTs are drug carriers) is beneficial to avoid the burst release of the drug. The drug loaded elctrospinning composite nanofibrous mats developed in this study may find various applications in tissues engineering and pharmaceutical sciences.

In vitro–in vivo–in silico simulation studies of anti-tubercular drugs doped with a self nanoemulsifying drug delivery system

RSC Advances ◽  
2016 ◽  
Vol 6 (95) ◽  
pp. 93147-93161 ◽  
Author(s):  
Afzal Hussain ◽  
Sandeep Kumar Singh ◽  
Neeru Singh ◽  
Priya Ranjan Prasad Verma
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Silico ◽  
Simulation Studies ◽  
System P ◽  
In Silico Simulation

This study aimed to formulate a self-nanoemulsifying drug delivery system (SNEDDS) for enhanced pharmacokinetic (PK) behavior of rifampicin and isoniazid using excipients holding innate anti-mycobacterial activity followed within vivo–in silicopredictions using GastroPlus™.

scholarly journals A glucose/O2 fuel cell-based self-powered biosensor for probing a drug delivery model with self-diagnosis and self-evaluation

2018 ◽  
Vol 9 (45) ◽  
pp. 8482-8491 ◽  
Author(s):  
Linlin Wang ◽  
Haohua Shao ◽  
Xuanzhao Lu ◽  
Wenjing Wang ◽  
Jian-Rong Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fuel Cell ◽  
Drug Delivery System ◽  
Delivery System ◽  
Self Evaluation ◽  
System P ◽  
Self Powered ◽  
Diagnosis Therapy ◽  
Evaluation Platform

A highly compact and self-sustained in vitro “diagnosis-therapy-evaluation” platform is developed by integrating a glucose/O2 fuel cell-based biosensor with a drug delivery system.

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