Synthesis of seminaphtho-phospha-fluorescein dyes based on the consecutive arylation of aryldichlorophosphines

2017 ◽  
Vol 53 (61) ◽  
pp. 8565-8568 ◽  
Author(s):  
Aiko Fukazawa ◽  
Junichi Usuba ◽  
Raúl A. Adler ◽  
Shigehiro Yamaguchi
Keyword(s):  
Phosphine Oxide ◽  
Nir Fluorescence ◽  
Fluorescein Dye ◽  
Fluorescein Dyes

Seminaphtho-phospha-fluorescein, a phosphine oxide-containing unsymmetric fluorescein dye with NIR fluorescence, was synthesized based on the consecutive arylation of PhPCl2.

Fluorescence ratio imaging of dynamic intracellular ionic signals

1988 ◽  
Vol 46 ◽  
pp. 42-43
Author(s):  
R. Y. Tsien ◽  
A. Minta ◽  
M. Poenie ◽  
J.P.Y. Kao ◽  
A. Harootunian
Keyword(s):  
Binding Sites ◽  
Living Cells ◽  
Molecular Engineering ◽  
Ph Indicators ◽  
Highly Sensitive ◽  
Fluorescence Ratio Imaging ◽  
Ratio Imaging ◽  
Technical Advances ◽  
Indicator Dyes ◽  
Fluorescein Dyes

Recent technical advances now enable the continuous imaging of important ionic signals inside individual living cells with micron spatial resolution and subsecond time resolution. This methodology relies on the molecular engineering of indicator dyes whose fluorescence is strong and highly sensitive to ions such as Ca2+, H+, or Na+, or Mg2+. The Ca2+ indicators, exemplified by fura-2 and indo-1, derive their high affinity (Kd near 200 nM) and selectivity for Ca2+ to a versatile tetracarboxylate binding site3 modeled on and isosteric with the well known chelator EGTA. The most commonly used pH indicators are fluorescein dyes (such as BCECF) modified to adjust their pKa's and improve their retention inside cells. Na+ indicators are crown ethers with cavity sizes chosen to select Na+ over K+: Mg2+ indicators use tricarboxylate binding sites truncated from those of the Ca2+ chelators, resulting in a more compact arrangement of carboxylates to suit the smaller ion.

Infrared fluorescence lymphography in experimental and clinical practice

2018 ◽  
Vol 17 (2) ◽  
pp. 84-91 ◽  
Author(s):  
G. V. Papayan ◽  
A. L. Akopov ◽  
P. A. Antonyan ◽  
A. A. Ilin ◽  
N. N. Petrishchev
Keyword(s):  
Lymph Nodes ◽  
Near Infrared ◽  
Lymphatic System ◽  
Lymphatic Vessels ◽  
Diagnostic System ◽  
Biological Tissues ◽  
Peritumoral Injection ◽  
Intradermal Administration ◽  
Nir Fluorescence ◽  
Real Time Visualization

Introduction. Near infrared (NIR) fluorescent diagnostics is promising due to a deeper penetration into biological tissues. Material and methods. In experiments on rabbits and in clinical studies evaluation the lymphatic system with the use of the instrument complex FLUM-808 was analysed. Results. For visualization of the lymphatic vessels of the skin, the intradermal administration of ICG, dissolved in 20 % albumin in the order of 0.02 mg/ml, is optimal. Peritumoral injection of ICG allows visualizing sentinel lymph nodes in patients with lung cancer. Conclusions. The developed NIR fluorescence diagnostic system FLUM-808 allows to real time visualization of lymphatic vessels and lymph nodes.

NIR Fluorescence Cholangiography With Low Dose of ICG

2019 ◽  
Author(s):  
Keyword(s):  
Low Dose ◽  
Nir Fluorescence

scholarly journals Emergency cricothyrotomy during the COVID-19 pandemic: how to suppress aerosolization

2020 ◽  
Vol 5 (1) ◽  
pp. e000542
Author(s):  
Nabil Issa ◽  
Whitney E Liddy ◽  
Sandeep Samant ◽  
David B Conley ◽  
Robert C Kern ◽  
...  
Keyword(s):  
Potential Risk ◽  
Healthcare Providers ◽  
Healthcare Setting ◽  
Healthcare Systems ◽  
Financial Resources ◽  
Risk Of Infection ◽  
X Ray ◽  
General Surgeons ◽  
Fluorescein Dye ◽  
Nose And Throat

BackgroundCricothyrotomy is associated with significant aerosolization that increases the potential risk of infection among healthcare providers. It is important to identify simple yet effective methods to suppress aerosolization and improve the safety of healthcare providers.Methods5 ear, nose and throat and general surgeons used a locally developed hybrid cricothyrotomy simulator with a porcine trachea to test three draping methods to suppress aerosolization during the procedure: an X-ray cassette drape, dry operating room (OR) towels and wet OR towels. The three methods were judged based on three categories: effectiveness of suppression, availability in all healthcare systems and ease of handling.ResultsAll five surgeons performed the procedure independently using each of the three suppression methods. The wet OR towel drape was found to be an effective method to suppress aerosolization, and it did not hinder the surgeons from performing the procedure accurately. This finding was confirmed by using an atomized fluorescein dye injection into the porcine trachea, representing aerosolized material while performing the procedure.ConclusionsWe present a novel intervention using wet towels to suppress aerosolization during cricothyrotomy. Wet towels are cheap and readily available within any healthcare setting regardless of the financial resources available.

scholarly journals Splatters and Aerosols Contamination in Dental Aerosol Generating Procedures

2021 ◽  
Vol 11 (4) ◽  
pp. 1914
Author(s):  
Pingping Han ◽  
Honghui Li ◽  
Laurence J. Walsh ◽  
Sašo Ivanovski
Keyword(s):  
Particle Size ◽  
Disease Transmission ◽  
High Speed ◽  
Low Speed ◽  
Dental Procedures ◽  
Dental Equipment ◽  
Produce Contamination ◽  
Fluorescein Dye ◽  
Filter Papers ◽  
Airborne Disease

Dental aerosol-generating procedures produce a large amount of splatters and aerosols that create a major concern for airborne disease transmission, such as COVID-19. This study established a method to visualise splatter and aerosol contamination by common dental instrumentation, namely ultrasonic scaling, air-water spray, high-speed and low-speed handpieces. Mock dental procedures were performed on a mannequin model, containing teeth in a typodont and a phantom head, using irrigation water containing fluorescein dye as a tracer. Filter papers were placed in 10 different locations to collect splatters and aerosols, at distances ranging from 20 to 120 cm from the source. All four types of dental equipment produced contamination from splatters and aerosols. At 120 cm away from the source, the high-speed handpiece generated the greatest amount and size (656 ± 551 μm) of splatter particles, while the triplex syringe generated the largest amount of aerosols (particle size: 1.73 ± 2.23 μm). Of note, the low-speed handpiece produced the least amount and size (260 ± 142 μm) of splatter particles and the least amount of aerosols (particle size: 4.47 ± 5.92 μm) at 120 cm. All four dental AGPs produce contamination from droplets and aerosols, with different patterns of distribution. This simple model provides a method to test various preventive strategies to reduce risks from splatter and aerosols.

Tris(4-(1-phenyl-1H-benzo[d]imidazole)phenyl)phosphine oxide for enhanced mobility and restricted traps in photovoltaic interlayers

2021 ◽  
Vol 9 (10) ◽  
pp. 3642-3651
Author(s):  
Jihyun Lim ◽  
Do-Yeong Choi ◽  
Woongsik Jang ◽  
Hyeon-Ho Choi ◽  
Yun-Hi Kim ◽  
...  
Keyword(s):  
Solar Cells ◽  
Electron Transport ◽  
Small Molecule ◽  
Phosphine Oxide ◽  
Organic Material ◽  
Perovskite Solar Cells ◽  
Effective Electron ◽  
Enhanced Mobility

Small molecule organic material, tris(4-(1-phenyl-1H-benzo[d]imidazole)phenyl)phosphine oxide (TIPO) was newly synthesised and introduced into an n-type interlayer in planar perovskite solar cells for effective electron transport.

scholarly journals Phosphine Oxide Derivative as a Passivating Agent to Enhance the Performance of Perovskite Solar Cells

2021 ◽  
Vol 4 (2) ◽  
pp. 1259-1268
Author(s):  
Albertus Adrian Sutanto ◽  
Cansu Igci ◽  
Hobeom Kim ◽  
Hiroyuki Kanda ◽  
Naoyuki Shibayama ◽  
...  
Keyword(s):  
Solar Cells ◽  
Phosphine Oxide ◽  
Perovskite Solar Cells ◽  
Oxide Derivative ◽  
Passivating Agent

Bright photo- and triboluminescence of centrosymmetric Eu(III) and Tb(III) complexes with phosphine oxides containing azaheterocycles

2021 ◽  
Author(s):  
Yuliya Bryleva ◽  
Alexander Artem'ev ◽  
Ludmila Alexsandrovna Glinskaya ◽  
Marianna I Rakhmanova ◽  
Denis G. Samsonenko ◽  
...  
Keyword(s):  
Phosphine Oxide ◽  
Phosphine Oxides

Six centrosymmetric mononuclear Eu3+ and Tb3+ complexes of the type [LnL2(hfac)3] have been synthesized employing diphenyl(pyridin-2-yl)phosphine oxide (Ph2P(O)Py), diphenyl(pyridimin-2-yl)phosphine oxide (Ph2P(O)Pym), and diphenyl(pyrazin-2-yl)phosphine oxide (Ph2P(O)Pyr) as supporting ligands (L). The...

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