A spiropyran–coumarin platform: an environment sensitive photoresponsive drug delivery system for efficient cancer therapy

2017 ◽  
Vol 5 (21) ◽  
pp. 3940-3944 ◽  
Author(s):  
Shrabani Barman ◽  
Joyjyoti Das ◽  
Sandipan Biswas ◽  
T. K. Maiti ◽  
N. D. Pradeep Singh
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Anticancer Agents ◽  
The Body

In spite of inventing several anticancer agents the clinical payoff still remains unsatisfactory because of their severe host toxicity due to their nonspecific biodistribution in the body.

scholarly journals Black phosphorus nanosheet-based new drug delivery system for the anticancer agents: A review

2021 ◽  
Vol 16 (2) ◽  
pp. 014-027
Author(s):  
Chaitanya A. Gulhane ◽  
Adarsh R. Durge ◽  
Jagdish V. Manwar ◽  
Ravindra L. Bakal
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Anticancer Agents ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Black Phosphorus ◽  
New Drug ◽  
Traditional Drug

Cancer has been one among the main threats to the lives of citizenry for hundreds of years. Traditional drug therapy has certain defects such as poor targeting, easy degradation, high side effects, etc. Therefore, to enhance the treatment efficiency of anticancer agents, there is need of developing new drug delivery systems. Black phosphorus is a member of the 2D family, and it possess the potential to construct drug delivery system by virtue of its photothermal therapy, photodynamic therapy, and biodegradable properties. Due to their special structure BP are considered to be the best platform for drug delivery. They have shown large potential as near-infrared photothermal therapy agents and drug delivery for cancer therapy. The present review covered advances in BP- based drug delivery system along with its advantages and applications in cancer therapy.

scholarly journals Development and Evaluation of Docetaxel-Phospholipid Complex Loaded Self-Microemulsifying Drug Delivery System: Optimization and In Vitro/Ex Vivo Studies

Pharmaceutics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 544
Author(s):  
Miao Wang ◽  
Sung-Kyun You ◽  
Hong-Ki Lee ◽  
Min-Gu Han ◽  
Hyeon-Min Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Anticancer Agents ◽  
Lipid Membrane ◽  
Ex Vivo ◽  
System Optimization ◽  
Raw Material ◽  
Phospholipid Complex ◽  
Low Solubility

Docetaxel (DTX) has clinical efficacy in the treatment of breast cancer, but it is difficult to develop a product for oral administration, due to low solubility and permeability. This study focused on preparing a self-microemulsifying drug delivery system (SME) loaded with DTX-phospholipid complex (DTX@PLC), to improve the dissolution and gastrointestinal (GI) permeability of DTX. A dual technique combining the phospholipid complexation and SME formulation described as improving upon the disadvantages of DTX has been proposed. We hypothesized that the complexation of DTX with phospholipids can improve the lipophilicity of DTX, thereby increasing the affinity of the drug to the cell lipid membrane, and simultaneously improving permeability through the GI barrier. Meanwhile, DTX@PLC-loaded SME (DTX@PLC-SME) increases the dissolution and surface area of DTX by forming a microemulsion in the intestinal fluid, providing sufficient opportunity for the drug to contact the GI membrane. First, we prepared DTX@PLC-SME by combining dual technologies, which are advantages for oral absorption. Next, we optimized DTX@PLC-SME with nanosized droplets (117.1 nm), low precipitation (8.9%), and high solubility (33.0 mg/g), which formed a homogeneous microemulsion in the aqueous phase. Dissolution and cellular uptake studies demonstrated that DTX@PLC-SME showed 5.6-fold higher dissolution and 2.3-fold higher DTX uptake in Caco-2 cells than raw material. In addition, an ex vivo gut sac study confirmed that DTX@PLC-SME improved GI permeability of DTX by 2.6-fold compared to raw material. These results suggested that DTX@PLC-SME can significantly overcome the disadvantages of anticancer agents, such as low solubility and permeability.

scholarly journals Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy

2018 ◽  
Vol 115 (3) ◽  
pp. 501-506 ◽  
Author(s):  
Meng Qiu ◽  
Dou Wang ◽  
Weiyuan Liang ◽  
Liping Liu ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Black Phosphorus ◽  
Deep Penetration ◽  
Nir Light

A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therapeutic efficacy for treatment of s.c. cancers. Importantly, our drug delivery system is completely harmless and degradable in vivo. Together, our work proposes a unique concept for precision cancer therapy by external light excitation to release cancer drugs. If these findings are successfully translated into the clinic, millions of patients with cancer will benefit from our work.

Functionalized halloysite nanotube by chitosan grafting for drug delivery of curcumin to achieve enhanced anticancer efficacy

2016 ◽  
Vol 4 (13) ◽  
pp. 2253-2263 ◽  
Author(s):  
Mingxian Liu ◽  
Yanzhou Chang ◽  
Jing Yang ◽  
Yuanyuan You ◽  
Rui He ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Halloysite Nanotube ◽  
Anticancer Efficacy

A new HNTs-based drug delivery system to improve the bioavailability of curcumin for cancer therapy is proposed.

scholarly journals Doxorubicin conjugated carbon dots as a drug delivery system for human breast cancer therapy

2018 ◽  
Vol 51 (5) ◽  
pp. e12488 ◽  
Author(s):  
Tingting Kong ◽  
Liying Hao ◽  
Yuanyuan Wei ◽  
Xiaoxiao Cai ◽  
Bofeng Zhu
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carbon Dots ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Breast Cancer Therapy

The Role of Polymer Carrier and Process Parameters for Small Molecule Drug Delivery via Blended Electrospinning

Nano LIFE ◽  
2021 ◽  
Vol 11 (02) ◽  
pp. 2150001
Author(s):  
Yasaman Hamedani ◽  
Murugabaskar Balan ◽  
Soumitro Pal ◽  
Sankha Bhowmick
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Fiber Diameter ◽  
The Body ◽  
Small Molecular Weight ◽  
Fibrous Scaffold ◽  
Water Contact ◽  
Polymer Carrier ◽  
Disease Specific

Delivery of therapeutic compounds to the diseased area in the body with minimized adverse effects is the underlying objective behind development of advanced drug delivery systems. Providing disease-specific release patterns is the ultimate goal of any drug delivery system. Electrospinning has been widely used for nanofiber fabrication. Having high aspect ratio and similarity to the extracellular matrix in the body make electrospun nanofibers a great candidate to be used as drug delivery implants. In this study, we report electrospinning to be a tunable technique capable of providing engineered, disease-specific drug release patterns. Using “one factor at a time” and “central composite design” techniques, we respectively demonstrate flow rate and applied voltage to be the two most significant parameters (with [Formula: see text]-values of 512.48 and 42.31) affecting the final fiber diameter, and capillary-to-collector distance as the least important one, by evaluating their influence, individually and combined, on the morphology of electrospun Poly (Lactide-co-Glycolide acid) nanofibers. Using the same two techniques, we also show that hydrophobicity of the polymeric fibrous scaffold, measured by water contact angle (WCA) with the [Formula: see text]-value of 376.44, is the main factor to consider when designing an electrospun fibrous drug delivery system for a specific disease, while fiber diameter can further modulate the release pattern of the drug from hydrophobic polymeric nanofibers. We finally support our hypothesis by comparing our findings with analysis of data derived from the literature. Taken together, our findings suggest electrospinning to be a tunable technique capable of providing various release patterns for any small molecular weight drug on the basis of the requirements of the diseases to be treated.

68Ga@pyridine-functionalized MCM-41 mesoporous silica: a novel radio labeled composite for diagnostic applications

2019 ◽  
Vol 107 (2) ◽  
pp. 157-164 ◽  
Author(s):  
Yousef Fazaeli ◽  
Mohammad Amin Hosseini ◽  
Mohammadreza Afrasyabi ◽  
Parviz Ashtari
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
The Body ◽  
Theranostic Agents ◽  
Diagnostic Applications ◽  
G Ratio ◽  
Mcm 41

Abstract Silica nanoparticles (SNPs) are known as intrinsic radiolabeling agents and offer a fast and reliable approach to deliver theranostic agents into targeted organs. Radiolabeled amorphous silica nanoparticles are of great interest to radiation oncology communities. In order to improve the performance of these nano materials in cancer diagnosis and treatment, their inherent properties, such as surface area and the ability to accumulate in cancer cells, should be enhanced. Pyridine functionalized mesoporous silica MCM-41 is known as a potential anticancer-drug delivery system with high suface area. In thiswork, in order to produce an image-guided drug delivery system for diagnostic applications, [68Ga] radionuclide was grafted on pyridine functionalized MCM-41. The nanoparticles were assessed with atomic force microscopy (AFM), paper chromatography, X-ray diffraction, FTIR spectroscopy, CHN and TGA/DTA analyses. The pharmacokinetic profile evaluation of the radiolabeled nano silica, [68Ga]-Py-Butyl@MCM-41, was done in Fibrosarcoma tumor-bearing mice. This labeled nanocomposite with appropriate blood circulation in body, high structural stability, high tumor/blood ID/g% ratio and fast excretion from the body can be proposed as an efficient nano engineered composite for upcoming tumor targeting/imaging nanotechnology-based applications.

scholarly journals The Impact of Magnesium–Aluminum-Layered Double Hydroxide-Based Polyvinyl Alcohol Coated on Magnetite on the Preparation of Core-Shell Nanoparticles as a Drug Delivery Agent

2019 ◽  
Vol 20 (15) ◽  
pp. 3764 ◽  
Author(s):  
Mona Ebadi ◽  
Kalaivani Buskaran ◽  
Bullo Saifullah ◽  
Sharida Fakurazi ◽  
Mohd Zobir Hussein
Keyword(s):  
Drug Delivery ◽  
Polyvinyl Alcohol ◽  
Drug Delivery System ◽  
Layered Double Hydroxide ◽  
Delivery System ◽  
The Body ◽  
Normal Fibroblast ◽  
Cellular Environment ◽  
Double Hydroxide ◽  
The Impact

One of the current developments in drug research is the controlled release formulation of drugs, which can be released in a controlled manner at a specific target in the body. Due to the diverse physical and chemical properties of various drugs, a smart drug delivery system is highly sought after. The present study aimed to develop a novel drug delivery system using magnetite nanoparticles as the core and coated with polyvinyl alcohol (PVA), a drug 5-fluorouracil (5FU) and Mg–Al-layered double hydroxide (MLDH) for the formation of FPVA-FU-MLDH nanoparticles. The existence of the coated nanoparticles was supported by various physico-chemical analyses. In addition, the drug content, kinetics, and mechanism of drug release also were studied. 5-fluorouracil (5FU) was found to be released in a controlled manner from the nanoparticles at pH = 4.8 (representing the cancerous cellular environment) and pH = 7.4 (representing the blood environment), governed by pseudo-second-order kinetics. The cytotoxicity study revealed that the anticancer delivery system of FPVA-FU-MLDH nanoparticles showed much better anticancer activity than the free drug, 5FU, against liver cancer and HepG2 cells, and at the same time, it was found to be less toxic to the normal fibroblast 3T3 cells.

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