scholarly journals Effects of ambient PM2.5and 9-nitroanthracene on DNA damage and repair, oxidative stress and metabolic enzymes in the lungs of rats

2017 ◽  
Vol 6 (5) ◽  
pp. 654-663 ◽  
Author(s):  
Ruijin Li ◽  
Lifang Zhao ◽  
Li Zhang ◽  
Minghui Chen ◽  
Jing Shi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lung Cancer ◽  
Dna Damage ◽  
Particulate Matter ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Fine Particulate Matter ◽  
Complex Mixture ◽  
Dna Damage And Repair ◽  
Fine Particulate

Ambient fine particulate matter (PM2.5) is a complex mixture associated with lung cancer risk.

scholarly journals Prospective analysis of DNA damage and repair markers of lung cancer risk from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial

2010 ◽  
Vol 32 (1) ◽  
pp. 69-73 ◽  
Author(s):  
Alice J. Sigurdson ◽  
Irene M. Jones ◽  
Qingyi Wei ◽  
Xifeng Wu ◽  
Margaret R. Spitz ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Damage ◽  
Cancer Screening ◽  
Cancer Risk ◽  
Lung Cancer Risk ◽  
Prospective Analysis ◽  
Dna Damage And Repair ◽  
Cancer Screening Trial ◽  
Screening Trial

Cancer risk from polycyclic aromatic compounds in fine particulate matter generated from household coal combustion in Xuanwei, China

Chemosphere ◽  
2017 ◽  
Vol 169 ◽  
pp. 660-668 ◽  
Author(s):  
K.H. Lui ◽  
Benjamin A. Musa Bandowe ◽  
Linwei Tian ◽  
Chi-Sing Chan ◽  
Jun-Ji Cao ◽  
...  
Keyword(s):  
Particulate Matter ◽  
Cancer Risk ◽  
Aromatic Compounds ◽  
Coal Combustion ◽  
Fine Particulate Matter ◽  
Polycyclic Aromatic Compounds ◽  
Fine Particulate ◽  
Polycyclic Aromatic

scholarly journals The critical role of endothelial function in fine particulate matter-induced atherosclerosis

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Shuang Liang ◽  
Jingyi Zhang ◽  
Ruihong Ning ◽  
Zhou Du ◽  
Jiangyan Liu ◽  
...  
Keyword(s):  
Air Pollution ◽  
Particulate Matter ◽  
Vascular Function ◽  
Fine Particulate Matter ◽  
Critical Role ◽  
Complex Mixture ◽  
Endothelial Injury ◽  
Vascular Endothelial ◽  
Vasomotor Function ◽  
Fine Particulate

AbstractAmbient and indoor air pollution contributes annually to approximately seven million premature deaths. Air pollution is a complex mixture of gaseous and particulate materials. In particular, fine particulate matter (PM2.5) plays a major mortality risk factor particularly on cardiovascular diseases through mechanisms of atherosclerosis, thrombosis and inflammation. A review on the PM2.5-induced atherosclerosis is needed to better understand the involved mechanisms. In this review, we summarized epidemiology and animal studies of PM2.5-induced atherosclerosis. Vascular endothelial injury is a critical early predictor of atherosclerosis. The evidence of mechanisms of PM2.5-induced atherosclerosis supports effects on vascular function. Thus, we summarized the main mechanisms of PM2.5-triggered vascular endothelial injury, which mainly involved three aspects, including vascular endothelial permeability, vasomotor function and vascular reparative capacity. Then we reviewed the relationship between PM2.5-induced endothelial injury and atherosclerosis. PM2.5-induced endothelial injury associated with inflammation, pro-coagulation and lipid deposition. Although the evidence of PM2.5-induced atherosclerosis is undergoing continual refinement, the mechanisms of PM2.5-triggered atherosclerosis are still limited, especially indoor PM2.5. Subsequent efforts of researchers are needed to improve the understanding of PM2.5 and atherosclerosis. Preventing or avoiding PM2.5-induced endothelial damage may greatly reduce the occurrence and development of atherosclerosis.

scholarly journals Fine Particulate Matter Leads to Unfolded Protein Response and Shortened Lifespan by Inducing Oxidative Stress in C. elegans

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Yunli Zhao ◽  
Ling Jin ◽  
Yuxin Chi ◽  
Jing Yang ◽  
Quan Zhen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Metabolic Enzyme ◽  
C Elegans ◽  
Unfolded Protein ◽  
Fine Particulate ◽  
Underlying Mechanisms ◽  
Protein Response ◽  
Phenylbutyric Acid

Oxidative stress has been proven as one of the most critical regulatory mechanisms involved in fine Particulate Matter- (PM2.5-) mediated toxicity. For a better understanding of the underlying mechanisms that enable oxidative stress to participate in PM2.5-induced toxic effects, the current study explored the effects of oxidative stress induced by PM2.5 on UPR and lifespan in C. elegans. The results implicated that PM2.5 exposure induced oxidative stress response, enhanced metabolic enzyme activity, activated UPR, and shortened the lifespan of C. elegans. Antioxidant N-acetylcysteine (NAC) could suppress the UPR through reducing the oxidative stress; both the antioxidant NAC and UPR inhibitor 4-phenylbutyric acid (4-PBA) could rescue the lifespan attenuation caused by PM2.5, indicating that the antioxidant and moderate proteostasis contribute to the homeostasis and adaptation to oxidative stress induced by PM2.5.

scholarly journals Contributions of City-Specific Fine Particulate Matter (PM2.5) to Differential In Vitro Oxidative Stress and Toxicity Implications between Beijing and Guangzhou of China

2019 ◽  
Vol 53 (5) ◽  
pp. 2881-2891 ◽  
Author(s):  
Ling Jin ◽  
Jiawen Xie ◽  
Chris K. C. Wong ◽  
Serena K. Y. Chan ◽  
Gülcin Abbaszade ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Fine Particulate
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