Smartphone-based analytical biosensors

The Analyst ◽  
2018 ◽  
Vol 143 (22) ◽  
pp. 5339-5351 ◽  
Author(s):  
Xiwei Huang ◽  
Dandan Xu ◽  
Jin Chen ◽  
Jixuan Liu ◽  
Yangbo Li ◽  
...  
Keyword(s):  
Mobile Health ◽  
Mass Production ◽  
Point Of Care ◽  
Rapid Development ◽  
Cost Effective

With the rapid development, mass production, and pervasive distribution of smartphones in recent years, they have provided people with portable, cost-effective, and easy-to-operate platforms to build analytical biosensors for point-of-care (POC) applications and mobile health.

The Scoping Review of Smart Healthcare Applications in Medical Health (Preprint)

2020 ◽  
Author(s):  
Cheng Hang Wu ◽  
Ching Ju Chiu ◽  
Yen Ju Liou ◽  
Chun Ying Lee ◽  
Susan C. Hu
Keyword(s):  
Systematic Reviews ◽  
Mobile Health ◽  
Scoping Review ◽  
Search Strategy ◽  
Rapid Development ◽  
Related Research ◽  
Geographic Access ◽  
Smart Healthcare ◽  
Research Findings ◽  
Healthcare Interventions

BACKGROUND There is still no consensus on research terms for smart healthcare worldwide. The study conducted by Lewis 10 years ago showed extending geographic access was the major health purpose of health-related information communication technology (ICT), but today's situation may be different because of the rapid development of smart healthcare. Objective: The main aim of this study is to classify recent smart healthcare interventions. Therefore, this scoping review was conducted as a feasible tool for exploring this domain and summarizing related research findings. OBJECTIVE The main aim of this study is to classify recent smart healthcare interventions. Therefore, this scoping review was conducted as a feasible tool for exploring this domain and summarizing related research findings. METHODS The scoping review relies on the analysis of previous reviews of smart healthcare interventions assessed for their effectiveness in the framework of a systematic review and/or meta-analysis. The search strategy was based on the identification of smart healthcare interventions reported as the proposed keywords. In the analysis, the reviews published from January 2015 to December 2019 were included. RESULTS The number of publications for smart healthcare's systematic reviews has continued to grow in the past five years. The search strategy yielded 210 systematic reviews and/or meta-analyses addressed to target groups of interest. 68.5% of these publications used mobile health as a keyword. According to the classification by Lewis, 37.62% of the literature was applied to extend geographic access. According to the classification by the Joint Commission of Taiwan (JCT), 48.84% of smart healthcare was applied in clinical areas, and 60% of it was applied in outpatient medical services. CONCLUSIONS Smart healthcare interventions are being widely used in clinical settings and for disease management. The research of mobile health has received the most attention among smart healthcare interventions. The main purpose of mobile health was used to extend geographic access to increase medical accessibility in clinical areas. CLINICALTRIAL none

scholarly journals Aptamer-Based Diagnostic Systems for the Rapid Screening of TB at the Point-of-Care

Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1352
Author(s):  
Darius Riziki Martin ◽  
Nicole Remaliah Sibuyi ◽  
Phumuzile Dube ◽  
Adewale Oluwaseun Fadaka ◽  
Ruben Cloete ◽  
...  
Keyword(s):  
Low Income ◽  
Point Of Care ◽  
Health Care Systems ◽  
Cost Effective ◽  
Rapid Screening ◽  
Low Income Countries ◽  
Sputum Smear ◽  
Diagnostic Systems ◽  
Molecular Tests ◽  
Rapid Tests

The transmission of Tuberculosis (TB) is very rapid and the burden it places on health care systems is felt globally. The effective management and prevention of this disease requires that it is detected early. Current TB diagnostic approaches, such as the culture, sputum smear, skin tuberculin, and molecular tests are time-consuming, and some are unaffordable for low-income countries. Rapid tests for disease biomarker detection are mostly based on immunological assays that use antibodies which are costly to produce, have low sensitivity and stability. Aptamers can replace antibodies in these diagnostic tests for the development of new rapid tests that are more cost effective; more stable at high temperatures and therefore have a better shelf life; do not have batch-to-batch variations, and thus more consistently bind to a specific target with similar or higher specificity and selectivity and are therefore more reliable. Advancements in TB research, in particular the application of proteomics to identify TB specific biomarkers, led to the identification of a number of biomarker proteins, that can be used to develop aptamer-based diagnostic assays able to screen individuals at the point-of-care (POC) more efficiently in resource-limited settings.

scholarly journals Longitudinal remotely mentored self-performed lung ultrasound surveillance of paucisymptomatic Covid-19 patients at risk of disease progression

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Andrew W. Kirkpatrick ◽  
Jessica L. McKee ◽  
John M. Conly
Keyword(s):  
At Risk ◽  
Lung Ultrasound ◽  
Point Of Care ◽  
Human Life ◽  
Vital Signs ◽  
Home Monitoring ◽  
Cost Effective ◽  
Care Providers ◽  
Vital Signs Monitoring ◽  
Ultrasound Probes

AbstractCOVID-19 has impacted human life globally and threatens to overwhelm health-care resources. Infection rates are rapidly rising almost everywhere, and new approaches are required to both prevent transmission, but to also monitor and rescue infected and at-risk patients from severe complications. Point-of-care lung ultrasound has received intense attention as a cost-effective technology that can aid early diagnosis, triage, and longitudinal follow-up of lung health. Detecting pleural abnormalities in previously healthy lungs reveal the beginning of lung inflammation eventually requiring mechanical ventilation with sensitivities superior to chest radiographs or oxygen saturation monitoring. Using a paradigm first developed for space-medicine known as Remotely Telementored Self-Performed Ultrasound (RTSPUS), motivated patients with portable smartphone support ultrasound probes can be guided completely remotely by a remote lung imaging expert to longitudinally follow the health of their own lungs. Ultrasound probes can be couriered or even delivered by drone and can be easily sterilized or dedicated to one or a commonly exposed cohort of individuals. Using medical outreach supported by remote vital signs monitoring and lung ultrasound health surveillance would allow clinicians to follow and virtually lay hands upon many at-risk paucisymptomatic patients. Our initial experiences with such patients are presented, and we believe present a paradigm for an evolution in rich home-monitoring of the many patients expected to become infected and who threaten to overwhelm resources if they must all be assessed in person by at-risk care providers.

scholarly journals Mass production of metal-doped graphene from the agriculture waste of Quercus ilex leaves for supercapacitors: inclusive DFT study

RSC Advances ◽  
2021 ◽  
Vol 11 (18) ◽  
pp. 10891-10901
Author(s):  
Gaurav Tatrari ◽  
Chetna Tewari ◽  
Manoj Karakoti ◽  
Mayank Pathak ◽  
Ritu Jangra ◽  
...  
Keyword(s):  
Effective Mass ◽  
Mass Production ◽  
Quercus Ilex ◽  
Cost Effective ◽  
Mass Scale ◽  
Graphene Sheets ◽  
Agriculture Waste ◽  
Doped Graphene ◽  
Metal Doped ◽  
Supercapacitor Applications

This work reports a facile, eco-friendly, and cost-effective mass-scale synthesis of metal-doped graphene sheets (MDGs) using agriculture waste of Quercus ilex leaves for supercapacitor applications.

scholarly journals Challenges for Evaluation of the Safety of Engineered Nanomaterials

2021 ◽  
Vol 43 (1) ◽  
pp. 4-7
Author(s):  
Linda J. Johnston ◽  
Norma Gonzalez-Rojano ◽  
Kevin J. Wilkinson ◽  
Baoshan Xing
Keyword(s):  
Rapid Development ◽  
Sustainable Use ◽  
Cost Effective ◽  
Engineered Nanomaterials ◽  
Full Potential ◽  
Effective Strategies ◽  
Toxicological Studies ◽  
Regulatory Guidelines ◽  
Significant Effort ◽  
Safe By Design

Abstract Nanotechnology has developed rapidly in the last two decades with significant effort focused on the development of nano-enabled materials with new or improved properties that offer solutions for current world challenges. The commercialization of products containing engineered nanomaterials (ENM) has progressed much more rapidly than the development of practical approaches to ensure their safe and sustainable use. The lack of adequate detection and characterization techniques and reproducible and validated methods for toxicological studies have been identified as major limitations. The rapid development of ENM of increasing complexity and diversity and concerns over the adequacy of existing regulations also contribute to safety concerns with these materials. The full potential of nanotechnology can only be realized when feasible, cost-effective strategies to ensure a safe-by-design approach, effective risk assessment approaches and appropriate regulatory guidelines are in place.

Smartphone Based Highly Sensitive Visualized Detection of Acid Phosphatase Enzyme Activity

2021 ◽  
Author(s):  
Rui Li ◽  
Yanan Sun ◽  
Lihua Jin ◽  
Xiaohong Qiao ◽  
Cong Li ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Acid Phosphatase ◽  
Point Of Care ◽  
Rapid Development ◽  
Practical Application ◽  
Fast Analysis ◽  
Highly Sensitive ◽  
Visualized Detection ◽  
Sensitive Method ◽  
Phosphatase Enzyme

With the rapid development of point-of-care (POC) technologies, the improvement of sensitive method featured with fast analysis and affordable devices has become an emerging requirement for the practical application. In...

scholarly journals 3D Printed Imaging Platform for Portable Cell Counting

The Analyst ◽  
2021 ◽  
Author(s):  
Diwakar M. Awate ◽  
Cicero C. Pola ◽  
Erica Shumaker ◽  
Carmen L Gomes ◽  
Jaime Javier Juarez
Keyword(s):  
3D Printing ◽  
Point Of Care ◽  
Cost Effective ◽  
Cell Counting ◽  
Biomedical Sciences ◽  
Widespread Application ◽  
Resource Limited ◽  
Cost Effective Approach ◽  
3D Printed

Despite having widespread application in the biomedical sciences, flow cytometers have several limitations that prevent their application to point-of-care (POC) diagnostics in resource-limited environments. 3D printing provides a cost-effective approach...

scholarly journals Direct diagnostic testing of SARS-CoV-2 without the need for prior RNA extraction

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Shan Wei ◽  
Esther Kohl ◽  
Alexandre Djandji ◽  
Stephanie Morgan ◽  
Susan Whittier ◽  
...  
Keyword(s):  
Limit Of Detection ◽  
Point Of Care ◽  
Diagnostic Testing ◽  
Rna Extraction ◽  
Cost Effective ◽  
Clinical Samples ◽  
Nasopharyngeal Swab ◽  
Percentage Agreement ◽  
Testing Method ◽  
Viral Transport

AbstractThe COVID-19 pandemic has resulted in an urgent need for a rapid, point of care diagnostic testing that could be rapidly scaled on a worldwide level. We developed and tested a highly sensitive and robust assay based on reverse transcription loop mediated isothermal amplification (RT-LAMP) that uses readily available reagents and a simple heat block using contrived spike-in and actual clinical samples. RT-LAMP testing on RNA-spiked samples showed a limit of detection (LoD) of 2.5 copies/μl of viral transport media. RT-LAMP testing directly on clinical nasopharyngeal swab samples in viral transport media had an 85% positive percentage agreement (PPA) (17/20), and 100% negative percentage agreement (NPV) and delivered results in 30 min. Our optimized RT-LAMP based testing method is a scalable system that is sufficiently sensitive and robust to test for SARS-CoV-2 directly on clinical nasopharyngeal swab samples in viral transport media in 30 min at the point of care without the need for specialized or proprietary equipment or reagents. This cost-effective and efficient one-step testing method can be readily available for COVID-19 testing world-wide, especially in resource poor settings.

scholarly journals High‐performance and cost‐effective melt blended poly(ether ether ketone)/expanded graphite composites for mass production of antistatic materials

2021 ◽  
Author(s):  
Mozaffar Mokhtari ◽  
Edward Archer ◽  
Noel Bloomfield ◽  
Eileen Harkin‐Jones ◽  
Alistair McIlhagger
Keyword(s):  
Mass Production ◽  
High Performance ◽  
Expanded Graphite ◽  
Cost Effective ◽  
Ether Ether Ketone ◽  
Poly Ether Ether Ketone ◽  
Ether Ketone ◽  
Graphite Composites

A Secure Robust and Privacy Enhanced Mobile Healthcare Framework

2018 ◽  
Vol 15 (3) ◽  
pp. 61-81
Author(s):  
Hisham M. Alsaghier ◽  
Shaik Shakeel Ahamad
Keyword(s):  
Health Systems ◽  
Mobile Health ◽  
Integrated Circuit ◽  
Cost Effective ◽  
Healthcare Services ◽  
Healthcare Industry ◽  
Continuous Transition ◽  
Trusted Platform Module ◽  
Mobile Healthcare ◽  
Mobile Health Systems

This article describes how the exponential growth of mobile applications has changed the way healthcare services function, and mobile healthcare using the Cloud is the most promising technology for healthcare industry. The mobile healthcare industry is in a continuous transition phase that requires continual innovation. There has been identified some of the challenges in the area of security protocols for mobile health systems which still need to be addressed in the future to enable cost-effective, secure and robust mobile health systems. This article addresses these challenges by proposing a secure robust and privacy-enhanced mobile healthcare framework (SRPF) by adopting a Community Cloud (CC), WPKI cryptosystems, Universal Integrated Circuit Cards (UICCs) and a Trusted Platform Module (TPM). All the security properties are provided within this framework. SRPF overcomes replay attacks, Man in the Middle (MITM) Attacks, Impersonation attacks and Multi-Protocol attacks as SRPF was successfully verified using a scyther tool and by BAN logic.

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