A smart and sensitive sensing platform to monitor the extracellular concentration of hydrogen peroxide in rat brain microdialysates during pathological processes based on mesoporous silica nanoparticles

2018 ◽  
Vol 10 (36) ◽  
pp. 4361-4366
Author(s):  
Guoyan Xu ◽  
Qunfang Xie ◽  
Zhonghui Chen ◽  
Fang Luo ◽  
Bin Qiu ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Rat Brain ◽  
Chemical Sensing ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Extracellular Concentration ◽  
Sensing Platform

An effective and biocompatible H2O2 stimuli-responsive chemical sensing platform has been developed based on mesoporous silica nanoparticles (MSNPs).

scholarly journals Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 71
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Agents ◽  
Metal Species ◽  
Stimuli Responsive ◽  
Combination Drug ◽  
Incidence And Mortality

With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

scholarly journals Mesoporous Silica Nanoparticles: Their Projection in Nanomedicine

2012 ◽  
Vol 2012 ◽  
pp. 1-20 ◽  
Author(s):  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Surrounding Medium ◽  
Stimuli Responsive ◽  
Guest Molecules ◽  
Different Types ◽  
Potential Applications ◽  
Inorganic Nanomaterials

Mesoporous silica nanoparticles are receiving growing attention by the scientific biomedical community. Among the different types of inorganic nanomaterials, mesoporous silica nanoparticles have emerged as promising multifunctional platforms for nanomedicine. Since their introduction in the drug delivery landscape in 2001, mesoporous materials for drug delivery are receiving growing scientific interest for their potential applications in the biotechnology and nanomedicine fields. The ceramic matrix efficiently protects entrapped guest molecules against enzymatic degradation or denaturation induced by pH and temperature as no swelling or porosity changes take place as a response to variations in the surrounding medium. It is possible to load huge amounts of cargo into the mesopore voids and capping the pore entrances with different nanogates. The application of a stimulus provokes the nanocap removal and triggers the departure of the cargo. This strategy permits the design of stimuli-responsive drug delivery nanodevices.

Colorimetric detection of hydrogen peroxide and glucose using the magnetic mesoporous silica nanoparticles

Talanta ◽  
2015 ◽  
Vol 134 ◽  
pp. 712-717 ◽  
Author(s):  
Yonghong Wang ◽  
Bo Zhou ◽  
Shun Wu ◽  
Kemin Wang ◽  
Xiaoxiao He
Keyword(s):  
Hydrogen Peroxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Colorimetric Detection ◽  
Magnetic Mesoporous Silica

scholarly journals Glucose-responsive mesoporous silica nanoparticles to generation of hydrogen peroxide for synergistic cancer starvation and chemistry therapy

2019 ◽  
Vol Volume 14 ◽  
pp. 2233-2251 ◽  
Author(s):  
Xiao Du ◽  
Tian Zhang ◽  
Guanglan Ma ◽  
Xiaochen Gu ◽  
Guangji Wang ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles

Stimuli-responsive flexible Lewis pair-modified nanoparticles for fluorescence imaging

2020 ◽  
Vol 56 (44) ◽  
pp. 5981-5984
Author(s):  
Nicole E. Arsenault ◽  
Kathleen T. Downey ◽  
Michael O. Wolf
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Fluorescence Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
Water Concentration ◽  
Stimuli Responsive ◽  
Biologically Relevant

Environment-responsive fluorophores are attached to mesoporous silica nanoparticles that can be used for sensing water concentration around biologically-relevant substrates.

scholarly journals Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery: an update

2019 ◽  
Vol 16 (4) ◽  
pp. 415-439 ◽  
Author(s):  
Rafael R. Castillo ◽  
Daniel Lozano ◽  
Blanca González ◽  
Miguel Manzano ◽  
Isabel Izquierdo-Barba ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive

Acid and light stimuli-responsive mesoporous silica nanoparticles for controlled release

2019 ◽  
Vol 54 (8) ◽  
pp. 6199-6211 ◽  
Author(s):  
Mingdong Wang ◽  
Ting Wang ◽  
Dong Wang ◽  
Wei Jiang ◽  
Jiajun Fu
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Light Stimuli

scholarly journals Synthesis of surface capped mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

MedChemComm ◽  
2017 ◽  
Vol 8 (9) ◽  
pp. 1797-1805 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Kang Dae Lee ◽  
Junghwan Oh
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Drug Delivery Applications

Herein, we propose a “host–guest” complexation-based mesoporous silica drug carrier, MSNs@Mela@TTM, for pH-responsive drug delivery applications in cancer therapy.

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