An injectable silk fibroin nanofiber hydrogel hybrid system for tumor upconversion luminescence imaging and photothermal therapy

2019 ◽  
Vol 43 (5) ◽  
pp. 2213-2219 ◽  
Author(s):  
Wei He ◽  
Po Li ◽  
Yue Zhu ◽  
Mingming Liu ◽  
Xiaonan Huang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Silk Fibroin ◽  
Hybrid System ◽  
Photothermal Therapy ◽  
Upconversion Luminescence ◽  
Upconversion Nanoparticles ◽  
Luminescence Imaging ◽  
Nano Graphene ◽  
Hydrogel System

In this paper, we developed a silk fibroin nanofiber (SF) hydrogel system complexed with upconversion nanoparticles and nano-graphene oxide (SF/UCNP@NGO) for upconversion luminescence imaging and photothermal therapy.

Smart pH-Responsive Nanocarriers Based on Nano-Graphene Oxide for Combined Chemo- and Photothermal Therapy Overcoming Drug Resistance

2014 ◽  
Vol 3 (8) ◽  
pp. 1261-1271 ◽  
Author(s):  
Liangzhu Feng ◽  
Kunyang Li ◽  
Xiaoze Shi ◽  
Min Gao ◽  
Jian Liu ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Graphene Oxide ◽  
Photothermal Therapy ◽  
Ph Responsive ◽  
Nano Graphene

Multifunctional NaYF4:Yb3+, Er3+@Au Nanocomposites: Upconversion Luminescence, Temperature Sensing and Photothermal Therapy

2015 ◽  
Vol 1088 ◽  
pp. 23-27 ◽  
Author(s):  
Dong Dong Li ◽  
Qi Yue Shao ◽  
Yan Dong ◽  
Jian Qing Jiang
Keyword(s):  
Gold Nanoparticles ◽  
Photothermal Therapy ◽  
Upconversion Luminescence ◽  
Separation Distance ◽  
Temperature Sensing ◽  
Upconversion Nanoparticles ◽  
Composite Nanostructures ◽  
Sensing Properties ◽  
Quenching Effect ◽  
Biomedical Fields

Composite nanostructures of NaYF4:Yb3+, Er3+@Au have been successfully prepared by attaching gold nanoparticles onto the surface of NaYF4: Yb3+, Er3+ upconversion nanoparticles (UCNPs). NaYF4 inert shell was used to adjust the separation distance between gold nanoparticles and UCNPs. Effects of the gold nanoparticles on their upconversion luminescent (UCL), temperature sensing and photothermal therapy properties were systematically investigated. For all samples, a slight decrease of the UCL intensity was observed after gold nanoparticles attachment, suggesting that the nonradiative quenching effect is the dominant interaction between UCNPs and gold nanoparticles. However, the reduction of the UCL intensity is negligible due to the significant improvement of UCL properties by NaYF4shell. In addition, the gold attachment can obviously improve the photothermal conversion effect, but do not affect the temperature sensing properties of NaYF4:Yb3+, Er3+ UCNPs, indicating their high capability for multifunctional applications in biomedical fields.

Multifunctional NaYF4:Yb,Er@PE3@Fe3O4 nanocomposites for magnetic-field-assisted upconversion imaging guided photothermal therapy of cancer cells

2019 ◽  
Vol 48 (34) ◽  
pp. 12850-12857 ◽  
Author(s):  
Shawei Fu ◽  
Yadan Ding ◽  
Tie Cong ◽  
Xiaoguang Yang ◽  
Xia Hong ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Cancer Cells ◽  
Therapeutic Efficacy ◽  
Photothermal Therapy ◽  
Upconversion Luminescence ◽  
Luminescence Imaging

Magnetic-field-assisted sensitive upconversion luminescence imaging and enhanced photothermal therapeutic efficacy were achieved with multifunctional NaYF4:Yb,Er@PE3@Fe3O4 nanocomposites.

Functionalized Nano-graphene Oxide as Multi-modal Clinic for Effective Drug Delivery

2017 ◽  
Vol 10 (4) ◽  
pp. 3768-3771
Author(s):  
Soumitra Satapathi ◽  
Rutusmita Mishra ◽  
Manisha Chatterjee ◽  
Partha Roy ◽  
Somesh Mohapatra
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Cancer Cell ◽  
High Surface ◽  
High Surface Area ◽  
Cancer Cell Line ◽  
Xrd Analysis ◽  
Graphene Derivatives ◽  
Nano Graphene

Nano-materials based drug delivery modalities to specific organs and tissues has become one of the critical endeavors in pharmaceutical research. Recently, two-dimensional graphene has elicited considerable research interest because of its potential application in drug delivery systems. Here we report, the drug delivery applications of PEGylated nano-graphene oxide (nGO-PEG), complexed with a multiphoton active and anti-cancerous diarylheptanoid drug curcumin. Specifically, graphene-derivatives were used as nanovectors for the delivery of the hydrophobic anticancer drug curcumin due to its high surface area and easy surface functionalization. nGO was synthesized by modified Hummer’s method and confirmed by XRD analysis. The formation of nGO, nGO-PEG and nGO-PEG-Curcumin complex were monitored through UV-vis, IR spectroscopy. MTT assay and AO/EB staining found that nGO-PEG-Curcumin complex afforded highly potent cancer cell killing in vitro with a human breast cancer cell line MCF7.

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