Recent advances of self-assembling peptide-based hydrogels for biomedical applications

Soft Matter ◽  
2019 ◽  
Vol 15 (8) ◽  
pp. 1704-1715 ◽  
Author(s):  
Jieling Li ◽  
Ruirui Xing ◽  
Shuo Bai ◽  
Xuehai Yan
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Biomedical Applications ◽  
3D Bioprinting ◽  
Biological Applications ◽  
Antitumor Therapy ◽  
Self Assembling ◽  
Recent Advances

The review introduces several methods for fabrication of robust peptide-based hydrogels and their biological applications in the fields of drug delivery and antitumor therapy, antimicrobial and wound healing materials, and 3D bioprinting and tissue engineering.

scholarly journals Rational Design of Peptide-based Smart Hydrogels for Therapeutic Applications

2021 ◽  
Vol 9 ◽  
Author(s):  
Saurav Das ◽  
Debapratim Das
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Rational Design ◽  
Soft Materials ◽  
Biological Molecules ◽  
3D Bioprinting ◽  
Significant Progress ◽  
Mechanical Stiffness

Peptide-based hydrogels have captivated remarkable attention in recent times and serve as an excellent platform for biomedical applications owing to the impressive amalgamation of unique properties such as biocompatibility, biodegradability, easily tunable hydrophilicity/hydrophobicity, modular incorporation of stimuli sensitivity and other functionalities, adjustable mechanical stiffness/rigidity and close mimicry to biological molecules. Putting all these on the same plate offers smart soft materials that can be used for tissue engineering, drug delivery, 3D bioprinting, wound healing to name a few. A plethora of work has been accomplished and a significant progress has been realized using these peptide-based platforms. However, designing hydrogelators with the desired functionalities and their self-assembled nanostructures is still highly serendipitous in nature and thus a roadmap providing guidelines toward designing and preparing these soft-materials and applying them for a desired goal is a pressing need of the hour. This review aims to provide a concise outline for that purpose and the design principles of peptide-based hydrogels along with their potential for biomedical applications are discussed with the help of selected recent reports.

scholarly journals Recent advances on biomedical applications of scaffolds in wound healing and dermal tissue engineering

2017 ◽  
Vol 46 (4) ◽  
pp. 691-705 ◽  
Author(s):  
Azizeh Rahmani Del Bakhshayesh ◽  
Nasim Annabi ◽  
Rovshan Khalilov ◽  
Abolfazl Akbarzadeh ◽  
Mohammad Samiei ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Dermal Tissue ◽  
Recent Advances

scholarly journals Recent advances on polydiacetylene-based smart materials for biomedical applications

2020 ◽  
Vol 4 (4) ◽  
pp. 1089-1104 ◽  
Author(s):  
Fang Fang ◽  
Fanling Meng ◽  
Liang Luo
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Tissue Engineering ◽  
Smart Materials ◽  
Biomedical Applications ◽  
Recent Advances ◽  
Smart Biomaterials

This review summarized most recent advances of designing strategies of polydiacetylene-based smart biomaterials with unique colorimetric and mechanical properties, as well as their applications in biosensing, drug delivery, and tissue engineering.

scholarly journals Antibacterial cellulose-based aerogels for wound healing application: A review

2020 ◽  
Vol 7 (10) ◽  
pp. 4032-4040
Author(s):  
Esam Bashir Yahya ◽  
Marwa Mohammed Alzalouk ◽  
Khalifa A. Alfallous ◽  
Abdullah F. Abogmaza
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Wound Dressing ◽  
Biomedical Applications ◽  
Inorganic Materials ◽  
Medical Applications ◽  
Tissue Engineering Scaffolds

Aerogels have been steadily developed since its first invention to become one of the most promising materials for various medical and non-medical applications. It has been prepared from organic and inorganic materials, in pure forms or composites. Cellulose-based aerogels are considered one of the promising materials in biomedical applications due to their availability, degradability, biocompatibility and non-cytotoxicity compared to conventional silica or metal-based aerogels. The unique properties of such materials permit their utilization in drug delivery, biosensing, tissue engineering scaffolds, and wound dressing. This review presents a summary of aerogel development as well as the properties and applications of aerogels. Herein, we further discuss the recent works pertaining to utilization of cellulose-based aerogels for antibacterial delivery.

Nanomaterials for bioprinting: functionalization of tissue-specific bioinks

2021 ◽  
Author(s):  
Andrea S. Theus ◽  
Liqun Ning ◽  
Linqi Jin ◽  
Ryan K. Roeder ◽  
Jianyi Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Regenerative Medicine ◽  
Biomedical Applications ◽  
Disease Modeling ◽  
Three Dimensional ◽  
3D Bioprinting ◽  
Significant Step ◽  
Printing Processes

Abstract Three-dimensional (3D) bioprinting is rapidly evolving, offering great potential for manufacturing functional tissue analogs for use in diverse biomedical applications, including regenerative medicine, drug delivery, and disease modeling. Biomaterials used as bioinks in printing processes must meet strict physiochemical and biomechanical requirements to ensure adequate printing fidelity, while closely mimicking the characteristics of the native tissue. To achieve this goal, nanomaterials are increasingly being investigated as a robust tool to functionalize bioink materials. In this review, we discuss the growing role of different nano-biomaterials in engineering functional bioinks for a variety of tissue engineering applications. The development and commercialization of these nanomaterial solutions for 3D bioprinting would be a significant step towards clinical translation of biofabrication.

scholarly journals Multifunctional Hydrogel Nanocomposites for Biomedical Applications

2021 ◽  
Author(s):  
Emma Barrett-Catton ◽  
Murial L. Ross ◽  
Prashanth Asuri
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Extracellular Matrix ◽  
Wound Healing ◽  
Physical Properties ◽  
Biomedical Applications ◽  
Biochemical Properties ◽  
Broad Applicability ◽  
Hydrogel Nanocomposites

Hydrogels are used for various biomedical applications due to their biocompatibility, capacity to mimic the extracellular matrix, and ability to encapsulate and deliver cells and therapeutics. However, traditional hydrogels have a few shortcomings, especially regarding their physical properties, thereby limiting their broad applicability. Recently, researchers have investigated the incorporation of nanoparticles (NPs) into hydrogels to improve and add to the physical and biochemical properties of hydrogels. This brief review focuses on papers that describe the use of nanoparticles to improve more than one property of hydrogels. Such multifunctional hydrogel nanocomposites have enhanced potential for various applications, including tissue engineering, drug delivery, wound healing, bioprinting and biowearable devices.

Short peptide based self-assembled nanostructures: implications in drug delivery and tissue engineering

2014 ◽  
Vol 5 (15) ◽  
pp. 4431-4449 ◽  
Author(s):  
Jiban Jyoti Panda ◽  
Virander Singh Chauhan
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Short Peptide ◽  
Self Assembling ◽  
Self Assembled

Self-assembling peptides with many potential biomedical applications.

scholarly journals Recent Advances in Chemically-Modified and Hybrid Carrageenan-Based Platforms for Drug Delivery, Wound Healing, and Tissue Engineering

Polymers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1744
Author(s):  
Hamidreza Mokhtari ◽  
Shima Tavakoli ◽  
Fereshteh Safarpour ◽  
Mahshid Kharaziha ◽  
Hamid Reza Bakhsheshi-Rad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Wound Healing ◽  
Polymer Networks ◽  
Three Dimensional ◽  
Biological Properties ◽  
Chemically Modified ◽  
Ionic Crosslinking ◽  
Crosslinking Process ◽  
Recent Advances

Recently, many studies have focused on carrageenan-based hydrogels for biomedical applications thanks to their intrinsic properties, including biodegradability, biocompatibility, resembling native glycosaminoglycans, antioxidants, antitumor, immunomodulatory, and anticoagulant properties. They can easily change to three-dimensional hydrogels using a simple ionic crosslinking process. However, there are some limitations, including the uncontrollable exchange of ions and the formation of a brittle hydrogel, which can be overcome via simple chemical modifications of polymer networks to form chemically crosslinked hydrogels with significant mechanical properties and a controlled degradation rate. Additionally, the incorporation of various types of nanoparticles and polymer networks into carrageenan hydrogels has resulted in the formation of hybrid platforms with significant mechanical, chemical and biological properties, making them suitable biomaterials for drug delivery (DD), tissue engineering (TE), and wound healing applications. Herein, we aim to overview the recent advances in various chemical modification approaches and hybrid carrageenan-based platforms for tissue engineering and drug delivery applications.

scholarly journals Alginate Modification and Lectin-Conjugation Approach to Synthesize the Mucoadhesive Matrix

2021 ◽  
Vol 11 (24) ◽  
pp. 11818
Author(s):  
Arlina Prima Putri ◽  
Francesco Picchioni ◽  
Sri Harjanto ◽  
Mochamad Chalid
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Enzymatic Degradation ◽  
Recent Progress ◽  
Graft Copolymerization ◽  
Specific Site ◽  
3D Bioprinting ◽  
Future Studies ◽  
New Perspective

Alginates are natural anionic polyelectrolytes investigated in various biomedical applications, such as drug delivery, tissue engineering, and 3D bioprinting. Functionalization of alginates is one possible way to provide a broad range of requirements for those applications. A range of techniques, including esterification, amidation, acetylation, phosphorylation, sulfation, graft copolymerization, and oxidation and reduction, have been implemented for this purpose. The rationale behind these investigations is often the combination of such modified alginates with different molecules. Particularly promising are lectin conjugate macromolecules for lectin-mediated drug delivery, which enhance the bioavailability of active ingredients on a specific site. Most interesting for such application are alginate derivatives, because these macromolecules are more resistant to acidic and enzymatic degradation. This review will report recent progress in alginate modification and conjugation, focusing on alginate-lectin conjugation, which is proposed as a matrix for mucoadhesive drug delivery and provides a new perspective for future studies with these conjugation methods.

scholarly journals Cryogels: recent applications in 3D-bioprinting, injectable cryogels, drug delivery, and wound healing

2021 ◽  
Vol 17 ◽  
pp. 2553-2569
Author(s):  
Luke O Jones ◽  
Leah Williams ◽  
Tasmin Boam ◽  
Martin Kalmet ◽  
Chidubem Oguike ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Biomedical Applications ◽  
Freezing Temperature ◽  
Wound Dressings ◽  
3D Bioprinting ◽  
Surgical Incision ◽  
Comprehensive Review ◽  
Highly Effective ◽  
Polymeric Structures

Cryogels are macroporous polymeric structures formed from the cryogelation of monomers/polymers in a solvent below freezing temperature. Due to their inherent interconnected macroporosity, ease of preparation, and biocompatibility, they are increasingly being investigated for use in biomedical applications such as 3D-bioprinting, drug delivery, wound healing, and as injectable therapeutics. This review highlights the fundamentals of macroporous cryogel preparation, cryogel properties that can be useful in the highlighted biomedical applications, followed by a comprehensive review of recent studies in these areas. Research evaluated includes the use of cryogels to combat various types of cancer, for implantation without surgical incision, and use as highly effective wound dressings. Furthermore, conclusions and outlooks are discussed for the use of these promising and durable macroporous cryogels.

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