Oxygen self-sufficient fluorinated polypeptide nanoparticles for NIR imaging-guided enhanced photodynamic therapy

Oxygen self-sufficient fluorinated polypeptide nanoparticles have been synthesized via the loading of a NIR photosensitizer (BODIPY-Br2) into a water-dispersible drug delivery system for high efficiency PDT.

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Researches on Preparation of Photosan Loaded Magnetic Silica Anoparticles and their Anti-Tumor Effects in Photodynamic Therapy

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.622-623.821 ◽

2012 ◽

Vol 622-623 ◽

pp. 821-826

Author(s):

Yu Wen ◽

Xiao Feng Deng ◽

Liang Liang Liu ◽

Shu Yun Shi ◽

Li Xiong

Keyword(s):

Drug Delivery ◽

Photodynamic Therapy ◽

Drug Delivery System ◽

Delivery System ◽

Sol Gel ◽

Haematoporphyrin Derivative ◽

X Ray Diffraction ◽

Transmission Electron ◽

Good Biocompatibility ◽

Low Solubility

Photodynamic therapy (PDT) is an effective, noninvasive and nontoxic therapeutics for cancer and some other diseases. It is becoming a alternative of traditional therapeutics for cancers. But the efficacy of PDT was restricted by insufficient selectivity and low solubility. In this study, novel multifunctional silica-based magnetic nanoparticles were prepared as targeting drug delivery system to achieve higher specificity and better solubility. Haematoporphyrin derivative (photosan) was used as photosensitizer. Magnetite nanoparticles (Fe3O4) and photosan were incorporated in silica nanoparticles by microemulsion and sol-gel methods. The prepared nanoparticles were characterized by X-ray diffraction, and transmission electron microscopy. The nanoparticles possessed good biocompatibility and could cause remarkable photodynamic anti-tumor effects. These suggested that photosan-Fe3O4 nanoparticles had great potential as effective drug delivery system in targeting photodynamic therapy.

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Doxorobicin as cargo in a redox-responsive drug delivery system capped with water dispersible ZnS nanoparticles

RSC Advances ◽

10.1039/d0ra02091e ◽

2020 ◽

Vol 10 (27) ◽

pp. 15825-15835

Author(s):

Lukáš Žid ◽

Vladimír Zeleňák ◽

Vladimír Girman ◽

Jozef Bednarčík ◽

Adriana Zeleňáková ◽

...

Keyword(s):

Magnetic Field ◽

Drug Delivery ◽

Drug Delivery System ◽

Anticancer Drug ◽

Delivery System ◽

Capping Agent ◽

Zns Nanoparticles ◽

Water Dispersible ◽

Redox Responsive ◽

Premature Release

Redox-responsive drug delivery system was studied. ZnS nanoparticles served as pore capping agent to prevent premature release of anticancer drug. Such cargo can be monitored by magnetic field which opens possibilities its use in theranostics.

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Novel Surface Modification of ZnO QDs for Paclitaxel-Targeted Drug Delivery for Lung Cancer Treatment

Dose-Response ◽

10.1177/1559325820926739 ◽

2020 ◽

Vol 18 (2) ◽

pp. 155932582092673

Author(s):

Chuan Xie ◽

Yan Zhan ◽

Peng Wang ◽

Bo Zhang ◽

Yukun Zhang

Keyword(s):

Drug Delivery ◽

Surface Modification ◽

Cancer Treatment ◽

Drug Delivery System ◽

Delivery System ◽

High Efficiency ◽

A549 Cells ◽

Cytotoxicity Studies

Adipic dihydrazide and heparin were attached to ZnO quantum dots surface, and the ZnO-adipic dihydrazide-heparin nanocomplex was used as a drug delivery system to deliver paclitaxel for chemotherapy. The surface modification and the loading of paclitaxel were confirmed by Fourier transform infrared spectrum, featured by characteristic peaks from functional groups of adipic dihydrazide, heparin, and paclitaxel. The impacts of pH on the drug release were investigated, and the cytotoxicity studies were conducted with A549 cells. The pharmacokinetic study was conducted with male Wistar rats. Both in vitro and in vivo study indicated that ZnO-adipic dihydrazide-heparin-paclitaxel nanocomplex could deliver paclitaxel in a more controllable way, and it has the potential to be a high-efficiency drug delivery system for cancer treatment.

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