scholarly journals A pillar[5]arene-based [2]rotaxane lights up mitochondria

2016 ◽  
Vol 7 (5) ◽  
pp. 3017-3024 ◽  
Author(s):  
Guocan Yu ◽  
Dan Wu ◽  
Yang Li ◽  
Zhihua Zhang ◽  
Li Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Targeted Drug Delivery ◽  
Therapeutic Agents ◽  
Delivery Platform ◽  
Targeted Drug ◽  
Mitochondria Targeting

Here we integrate diagnostic and therapeutic agents into a mitochondria-targeting [2]rotaxane, which can be utilized as a drug delivery platform to conjugate anticancer drugs to prepare prodrugs for efficient targeted drug delivery.

Heat Stress and Pulsed Unfocused Ultrasound: The Viability of these Physical Approaches for Drug Delivery into Testicular Seminiferous Tubules

2020 ◽  
Vol 17 (5) ◽  
pp. 438-446 ◽  
Author(s):  
Yuanyuan Li ◽  
Mohammad Ishraq Zafar ◽  
Xiaotong Wang ◽  
Xiaofang Ding ◽  
Honggang Li
Keyword(s):  
Drug Delivery ◽  
Heat Stress ◽  
Targeted Drug Delivery ◽  
Therapeutic Agents ◽  
Seminiferous Tubules ◽  
Adult Mice ◽  
Targeted Drug ◽  
To Receive ◽  
Unfocused Ultrasound ◽  
Blood Testis Barrier

Aim: To investigate the application of Scrotal Heat Stress (SHS) and Pulsed Unfocused Ultrasound (PuFUS) to explore Blood-Testis Barrier (BTB) permeability in adult mice. Background: The BTB provides a stable microenvironment and a unique immune barrier for spermatogenesis. Meanwhile, it blocks macromolecular substances access, including therapeutic agents and antibodies, thereby it decreases the therapeutic or immunocontraception effects. Objectives: To determine the viability of these physical approaches in delivering macromolecular substances into seminiferous tubules. Material & Methods: Mice were subjected to receive single SHS intervention at 39°C, 41°C, or 43°C for 30 min. Whereas, mice received the PuFUS intervention at 1.75w/cm2, 1.25w/cm2, and 2.5w/cm2 for 2 min, 5 min, and 10 min, respectively. The Biotin and macromolecular substances (IgG, IgM, and exosomes) were separately injected into the testicular interstitium at different times following SHS or PuFUS interventions, to observe their penetration through BTB into seminiferous tubules. Results: As detected by Biotin tracer, the BTB opening started from day-2 following the SHS and lasted for more than three days, whereas the BTB opening started from 1.5h following PuFUS and lasted up to 24h. Apparent penetration of IgG, IgM, and exosomes into seminiferous tubules was observed after five days of the SHS at 43°C, but none at 39°C, or any conditions tested with PuFUS. Conclusion: The current results indicate that SHS at 43°C comparatively has the potential for delivering macromolecular substances into seminiferous tubules, whereas the PuFUS could be a novel, quick, and mild approach to open the BTB. These strategies might be useful for targeted drug delivery into testicular seminiferous tubules. However, further studies are warranted to validate our findings.

scholarly journals SW43-DOX ± loading onto drug-eluting bead, a potential new targeted drug delivery platform for systemic and locoregional cancer treatment - An in vitro evaluation

2016 ◽  
Vol 10 (7) ◽  
pp. 1133-1145 ◽  
Author(s):  
Johannes M. Ludwig ◽  
Yongkang Gai ◽  
Lingyi Sun ◽  
Guangya Xiang ◽  
Dexing Zeng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Targeted Drug Delivery ◽  
In Vitro Evaluation ◽  
Drug Eluting ◽  
Delivery Platform ◽  
Targeted Drug

scholarly journals Recent trends on hydrogel based drug delivery systems for infectious diseases

2016 ◽  
Vol 4 (11) ◽  
pp. 1535-1553 ◽  
Author(s):  
Arti Vashist ◽  
Ajeet Kaushik ◽  
Atul Vashist ◽  
Rahul Dev Jayant ◽  
Asahi Tomitaka ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Infectious Diseases ◽  
Targeted Drug Delivery ◽  
Drug Delivery Systems ◽  
Therapeutic Agents ◽  
Delivery Systems ◽  
Recent Trends ◽  
Targeted Drug ◽  
Targeted Drug Delivery Systems

Hydrogel based drug delivery systems owe excellent potential as targeted drug delivery systems for the delivery of therapeutic agents and diagnostics for major infectious diseases.

An Aptamer–Doxorubicin Physical Conjugate as a Novel Targeted Drug-Delivery Platform

2006 ◽  
Vol 45 (48) ◽  
pp. 8149-8152 ◽  
Author(s):  
Vaishali Bagalkot ◽  
Omid C. Farokhzad ◽  
Robert Langer ◽  
Sangyong Jon
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Delivery Platform ◽  
Targeted Drug

Design and synthesis of aptamer AS1411-conjugated EG@TiO2@Fe2O3 nanoparticles as a drug delivery platform for tumor-targeted therapy

2020 ◽  
Vol 44 (37) ◽  
pp. 15871-15886 ◽  
Author(s):  
Nahid Mansouri ◽  
Razieh Jalal ◽  
Batool Akhlaghinia ◽  
Khalil Abnous ◽  
Roya Jahanshahi
Keyword(s):  
Drug Delivery ◽  
Targeted Therapy ◽  
Sustained Release ◽  
Targeted Drug Delivery ◽  
Fe2o3 Nanoparticles ◽  
Ph Responsive ◽  
Release System ◽  
Design And Synthesis ◽  
Delivery Platform ◽  
Targeted Drug

AS1411@GMBS@EG@TiO2@Fe2O3 nanoparticle is an effective and safe pH-responsive sustained release system for targeted drug delivery into nucleolin-positive cells.

A Review on Targeting Nanoparticles for Breast Cancer

2019 ◽  
Vol 20 (13) ◽  
pp. 1087-1107 ◽  
Author(s):  
Hasanain Gomhor J. Alqaraghuli ◽  
Soheila Kashanian ◽  
Ronak Rafipour
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Targeted Drug Delivery ◽  
Breast Cancer Cells ◽  
Pharmaceutical Research ◽  
Chemotherapeutic Agents ◽  
Great Promise ◽  
Targeted Drug

Chemotherapeutic agents have been used extensively in breast cancer remedy. However, most anticancer drugs cannot differentiate between cancer cells and normal cells, leading to toxic side effects. Also, the resulted drug resistance during chemotherapy reduces treatment efficacy. The development of targeted drug delivery offers great promise in breast cancer treatment both in clinical applications and in pharmaceutical research. Conjugation of nanocarriers with targeting ligands is an effective therapeutic strategy to treat cancer diseases. In this review, we focus on active targeting methods for breast cancer cells through the use of chemical ligands such as antibodies, peptides, aptamers, vitamins, hormones, and carbohydrates. Also, this review covers all information related to these targeting ligands, such as their subtypes, advantages, disadvantages, chemical modification methods with nanoparticles and recent published studies (from 2015 to present). We have discussed 28 different targeting methods utilized for targeted drug delivery to breast cancer cells with different nanocarriers delivering anticancer drugs to the tumors. These different targeting methods give researchers in the field of drug delivery all the information and techniques they need to develop modern drug delivery systems.

Targeted Drug Delivery System for Platinum-based Anticancer Drugs

2016 ◽  
Vol 16 (11) ◽  
pp. 872-891 ◽  
Author(s):  
Chuanzhu Gao ◽  
Yan Zhang ◽  
Ji Chen ◽  
Tianshuai Wang ◽  
Yunxu Qian ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Anticancer Drugs ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

MS2 Viruslike Particles: A Robust, Semisynthetic Targeted Drug Delivery Platform

2012 ◽  
Vol 10 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Francis A. Galaway ◽  
Peter G. Stockley
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Delivery Platform ◽  
Targeted Drug ◽  
Viruslike Particles
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