scholarly journals Through the eyes of a pathogen: light perception and signal transduction inAcinetobacter baumannii

2019 ◽  
Vol 18 (10) ◽  
pp. 2363-2373 ◽  
Author(s):  
Alejandro Pezza ◽  
Marisel Tuttobene ◽  
Inés Abatedaga ◽  
Lorena Valle ◽  
Claudio D. Borsarelli ◽  
...  

Sunlight is a ubiquitous environmental stimulus for the great majority of living organisms on Earth; therefore it is logical to expect the development of “seeing mechanisms” which lead them to successfully adapt to particular ecological niches.

2012 ◽  
Vol 2012 ◽  
pp. 1-14 ◽  
Author(s):  
Greco Hernández ◽  
Christopher G. Proud ◽  
Thomas Preiss ◽  
Armen Parsyan

Diversity is one of the most remarkable features of living organisms. Current assessments of eukaryote biodiversity reaches 1.5 million species, but the true figure could be several times that number. Diversity is ingrained in all stages and echelons of life, namely, the occupancy of ecological niches, behavioral patterns, body plans and organismal complexity, as well as metabolic needs and genetics. In this review, we will discuss that diversity also exists in a key biochemical process, translation, across eukaryotes. Translation is a fundamental process for all forms of life, and the basic components and mechanisms of translation in eukaryotes have been largely established upon the study of traditional, so-called model organisms. By using modern genome-wide, high-throughput technologies, recent studies of many nonmodel eukaryotes have unveiled a surprising diversity in the configuration of the translation apparatus across eukaryotes, showing that this apparatus is far from being evolutionarily static. For some of the components of this machinery, functional differences between different species have also been found. The recent research reviewed in this article highlights the molecular and functional diversification the translational machinery has undergone during eukaryotic evolution. A better understanding of all aspects of organismal diversity is key to a more profound knowledge of life.


2015 ◽  
Vol 2015 ◽  
pp. 1-18 ◽  
Author(s):  
Grzegorz Redlarski ◽  
Bogdan Lewczuk ◽  
Arkadiusz Żak ◽  
Andrzej Koncicki ◽  
Marek Krawczuk ◽  
...  

Current technologies have become a source of omnipresent electromagnetic pollution from generated electromagnetic fields and resulting electromagnetic radiation. In many cases this pollution is much stronger than any natural sources of electromagnetic fields or radiation. The harm caused by this pollution is still open to question since there is no clear and definitive evidence of its negative influence on humans. This is despite the fact that extremely low frequency electromagnetic fields were classified as potentially carcinogenic. For these reasons, in recent decades a significant growth can be observed in scientific research in order to understand the influence of electromagnetic radiation on living organisms. However, for this type of research the appropriate selection of relevant model organisms is of great importance. It should be noted here that the great majority of scientific research papers published in this field concerned various tests performed on mammals, practically neglecting lower organisms. In that context the objective of this paper is to systematise our knowledge in this area, in which the influence of electromagnetic radiation on lower organisms was investigated, including bacteria,E. coliandB. subtilis, nematode,Caenorhabditis elegans, land snail,Helix pomatia, common fruit fly,Drosophila melanogaster, and clawed frog,Xenopus laevis.


2021 ◽  
Author(s):  
Yusu Xie ◽  
Liusuo Zhang

Salinity is a critical abiotic factor for all living organisms. The ability to adapt to different salinity environments determines an organism′s survival and ecological niches. Litoditis marina is a euryhaline marine nematode widely distributed in coastal ecosystems all over the world, although numerous genes involved in its salinity response have been reported, the adaptive mechanisms underlying its euryhalinity remain unexplored. Here, we utilized worms which have been acclimated to either low salinity or high salinity conditions and evaluated their basal gene expression at both transcriptomic and proteomic levels. We found that several conserved regulators, including osmolytes biosynthesis genes, transthyretin-like family genes, V-type H+-transporting ATPase and potassium channel genes, were involved in both short-term salinity stress response and long-term acclimation processes. In addition, we identified genes related to cell volume regulation, such as actin regulatory genes, Rho family small GTPases and diverse ion transporters, might contribute to hyposaline acclimation, while the glycerol biosynthesis genes gpdh-1 and gpdh-2 accompanied hypersaline acclimation in L. marina. Furthermore, gpdh-2 might play an essential role in transgenerational inheritance of osmotic stress protection in L. marina as in its relative nematode Caenorhabditis elegans. Hereby, this study paves the way for further in-depth exploration on adaptive mechanisms underlying euryhalinity, and may also contribute to the studies of healthy ecosystems in the context of global climate change.


2020 ◽  
Vol 21 (21) ◽  
pp. 7990
Author(s):  
Larisa N. Ikryannikova ◽  
Leonid K. Kurbatov ◽  
Neonila V. Gorokhovets ◽  
Andrey A. Zamyatnin

Over millions of years of evolution, bacteria have developed complex strategies for intra-and interspecies interactions and competition for ecological niches and resources. Contact-dependent growth inhibition systems (CDI) are designed to realize a direct physical contact of one bacterial cell with other cells in proximity via receptor-mediated toxin delivery. These systems are found in many microorganisms including clinically important human pathogens. The main purpose of these systems is to provide competitive advantages for the growth of the population. In addition, non-competitive roles for CDI toxin delivery systems including interbacterial signal transduction and mediators of bacterial collaboration have been suggested. In this review, our goal was to systematize the recent findings on the structure, mechanisms, and purpose of CDI systems in bacterial populations and discuss the potential biological and evolutionary impact of CDI-mediated interbacterial competition and/or cooperation.


Author(s):  
Wilhelm Halbfass

The combined beliefs in karma and rebirth, that is, the retributive power of actions and decisions and a beginningless, though not necessarily endless, succession of births and deaths for living beings, constitute a fundamental premise of the great majority of India’s religious and philosophical traditions. The suggestion first made by the great Muslim scholar al-Biruni (973–1048) that they are the fundamental creed of Indian religious thought in general may be questionable, but it is certainly understandable. Although such notions are by no means exclusively Indian, they have played a far more central and pervasive role in India than in any other cultural domain. In a sense, the idea of karmic retribution postulates that the act itself will hold its originator responsible and accountable. Acts of moral or ritual significance will bring about their own reward or punishment, that is, favourable or unfavourable experiences. On the other hand, favourable or unfavourable experiences and conditions are forms of reward or punishment for past actions and decisions. Karmic retribution takes place through a sequence of countless existences and may involve a movement through a vast variety of forms of life. More specifically, this implies that birth into a particular species, physiological and psychological features, sex, social status, life span, exposure to pleasant or unpleasant experiences, and so on, appear as results of previous actions (usually acts committed in previous lives), and that current actions are expected to have a corresponding influence on future existences. In Sanskrit, the realm of rebirth and karmic retribution is known as saṃsāra. Its precise scope has been subject to some debate. The most common assumption is that it coincides with sentient existence and includes the entire hierarchy of living organisms from the gods down to the plants. While later Buddhism tends to exclude the plants from this domain, Jainism finds forms of life and sentience even in the elements water, earth, and so forth. Most schools of philosophy view being in saṃsāra as a condition of bondage, suffering and alienation; even karmic ascent is ultimately undesirable. The ability to transcend this condition by transforming and eventually eliminating the power of karma is often associated with human existence and considered a rare privilege. Most forms of life are just forms of karmic retribution, without any capacity for karmic initiative. The historical origins of the doctrine of karma and rebirth cannot be determined with certainty and precision. While the Vedas and Brāhmaṇas provide significant antecedents, they do not show any clear recognition of the doctrine as such. Even in the older Upaniṣads (prior to 500 bc), its formulations are still tentative, partial and more or less isolated. It seems that the teachings of the Buddha added a new and stricter notion of causality and a far more explicit sense of moral responsibility and universal applicability to the older versions. The other important reform movement of this period, Jainism, showed an early commitment to a systematic elaboration of karmic factors and processes. Unlike the Buddhists, the Jainas developed a reified, even substantialist notion of karma. In Hindu literature, such texts as the great epic the Mahābhārata (beginning around 400 bc) give clear evidence of a fully developed and generally recognized doctrine of karma and rebirth. Subsequently, the doctrine was adopted and variously interpreted by most schools of philosophical and religious thought. It served, moreover, as a basic premise of law texts, popular narratives and mythologies, and a wide array of traditional ‘sciences’, such as medicine, embryology and astrology. Significant disagreements and debates occurred with regard to the status and character of the karmic agent and the subject of transmigration and rebirth (most conspicuously in connection with the Buddhist denial of a durable ‘self’ or ātman). The moral relevance and metaphysical qualities of acts and decisions, the nature of karmic causality and the mechanism of rebirth, the possibility of a transfer of karma, the compatibility of knowledge and action, and the prospects of and problems concerning the elimination of karma and the ultimate transcendence of rebirth provided further topics of debate. In its various contexts and applications, the doctrine of karma and saṃsāra has at least three different yet interrelated functions and dimensions: it is used to provide causal explanations (especially in the realm of life); it serves as a framework for ethical discipline and religious orientation; and it provides the rationale for a fundamental dissatisfaction with worldly existence and a commitment to final liberation from such existence. The ways in which these functions have been balanced or correlated with one another reflect fundamental trends and tensions in the Indian tradition in general.


1997 ◽  
Vol 61 (3) ◽  
pp. 319-336
Author(s):  
J H Crosa

Iron is an essential element for nearly all living cells. Thus, the ability of bacteria to utilize iron is a crucial survival mechanism independent of the ecological niche in which the microorganism lives, because iron is scarce both in potential biological hosts, where it is bound by high-affinity iron-binding proteins, and in the environment, where it is present as part of insoluble complex hydroxides. Therefore, pathogens attempting to establish an infection and environmental microorganisms must all be able to utilize the otherwise unavailable iron. One of the strategies to perform this task is the possession of siderophore-mediated iron uptake systems that are capable of scavenging the hoarded iron. This metal is, however, a double-edged sword for the cell because it can catalyze the production of deadly free hydroxyl radicals, which are harmful to the cells. It is therefore imperative for the cell to control the concentration of iron at levels that permit key metabolic steps to occur without becoming a messenger of cell death. Early work identified a repressor, Fur, which as a complex with iron repressed the expression of most iron uptake systems as well as other iron-regulated genes when the iron concentration reached a certain level. However, later work demonstrated that this regulation by Fur was not the only answer under low-iron conditions, there was a need for activation of iron uptake genes as well as siderophore biosynthetic genes. Furthermore, it was also realized that in some instances the actual ferric iron-siderophore complex induced the transcription of the cognate receptor and transport genes. It became evident that control of the expression of iron-regulated genes was more complex than originally envisioned. In this review, I analyze the processes of signal transduction, transcriptional control, and posttranscriptional control of iron-regulated genes as reported for the ferric dicitrate system in Escherichia coli; the pyochelin, pyoverdin, and enterobactin systems in Pseudomonas species; the irgB system in Vibrio cholerae; and the plasmid-mediated anguibactin system in Vibrio anguillarum. I hope that by using these diverse paradigms, I will be able to convey a unifying picture of these mechanism and their importance in the maintenance and prosperity of bacteria within their ecological niches.


1999 ◽  
pp. 796-820 ◽  
Author(s):  
Jitendra P. Khurana ◽  
Kenneth L. Poff

2021 ◽  
Vol 17 ◽  
Author(s):  
Songbai Zhang ◽  
Shuang Li ◽  
Rixin Yan ◽  
Zhiyun Zhou ◽  
Yuting Wu ◽  
...  

Background: Personal glucose meter (PGM) has become the most successful biosensor in past decades due to its advantages of small size, convenient operation, and low cost. To take advantage of many years of research and development of PGMs, new signal transduction methods has been developed to expand the PGM from simple monitoring blood glucose to detection of numerous non-glucose targets. Objectives: This review summarizes recent advance of PGM-based biosensors for non-glucose targets including signal transduction, signal amplification and target molecule recognition and analysis. Current challenges and future directions are also discussed. Conclusion: PGM can be used as biosensor readout to detect various non-glucose targets from metal ion, small molecule to protein and even living organisms such as bacteria and other pathogens by using different signal transduction elements such as invertase and amylase, and different signal amplification methods such as nanomaterials, nucleic acid reaction, liposome encapsulation, hydrogel trapping, DNAzyme amplification and biotin-streptavidin reaction.


Sign in / Sign up

Export Citation Format

Share Document