Synthesis and self-assembly of photoacid-containing block copolymers based on 1-naphthol

2019 ◽  
Vol 10 (41) ◽  
pp. 5602-5616 ◽  
Author(s):  
Felix Wendler ◽  
Jessica C. Tom ◽  
Felix H. Schacher
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Molecular Switches ◽  
Amphiphilic Block Copolymers ◽  
Strong Increase ◽  
Stimuli Responsive ◽  
Responsive Materials

Photoacids experience a strong increase in acidity when absorbing light and, hence, can be considered as molecular switches. The incorporation into amphiphilic block copolymers leads to novel stimuli-responsive materials with great potential.

scholarly journals Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances

2021 ◽  
Vol 9 (1) ◽  
pp. 38-50
Author(s):  
Hien Phan ◽  
Vincenzo Taresco ◽  
Jacques Penelle ◽  
Benoit Couturaud
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Delivery Systems ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Site Specific ◽  
On Demand ◽  
Redox Agents

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

scholarly journals Self-Assembly Behavior and pH-Stimuli-Responsive Property of POSS-Based Amphiphilic Block Copolymers in Solution

Micromachines ◽  
2018 ◽  
Vol 9 (6) ◽  
pp. 258 ◽  
Author(s):  
Yiting Xu ◽  
Kaiwei He ◽  
Hongchao Wang ◽  
Meng Li ◽  
Tong Shen ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Amphiphilic Block Copolymers ◽  
Stimuli Responsive ◽  
Assembly Behavior

scholarly journals pH- and concentration-dependent supramolecular self-assembly of a naturally occurring octapeptide

2020 ◽  
Vol 16 ◽  
pp. 2017-2025
Author(s):  
Goutam Ghosh ◽  
Gustavo Fernández
Keyword(s):  
Self Assembly ◽  
Ph Value ◽  
Secondary Structures ◽  
Random Coil ◽  
Conformational Transformation ◽  
Stimuli Responsive ◽  
Responsive Materials ◽  
Force Microscopy ◽  
Assembly Behavior ◽  
Novel Drug

Peptide-based biopolymers represent highly promising biocompatible materials with multiple applications, such as tailored drug delivery, tissue engineering and regeneration, and as stimuli-responsive materials. Herein, we report the pH- and concentration-dependent self-assembly and conformational transformation of the newly synthesized octapeptide PEP-1. At pH 7.4, PEP-1 forms β-sheet-rich secondary structures into fractal-like morphologies, as verified by circular dichroism (CD), Fourier-transform infrared (FTIR) spectroscopy, thioflavin T (ThT) fluorescence spectroscopy assay, and atomic force microscopy (AFM). Upon changing the pH value (using pH 5.5 and 13.0), PEP-1 forms different types of secondary structures and resulting morphologies due to electrostatic repulsion between charged amino acids. PEP-1 can also form helical or random-coil secondary structures at a relatively low concentration. The obtained pH-sensitive self-assembly behavior of the target octapeptide is expected to contribute to the development of novel drug nanocarrier assemblies.

scholarly journals Redox-triggered switching in three-dimensional covalent organic frameworks

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Chao Gao ◽  
Jian Li ◽  
Sheng Yin ◽  
Junliang Sun ◽  
Cheng Wang
Keyword(s):  
Solid State ◽  
Three Dimensional ◽  
Molecular Switches ◽  
Pore Channel ◽  
Pore Surface ◽  
Stimuli Responsive ◽  
Conversion Yield ◽  
Responsive Materials ◽  
Reversible Transformation ◽  
Internal Pore

Abstract The tuning of molecular switches in solid state toward stimuli-responsive materials has attracted more and more attention in recent years. Herein, we report a switchable three-dimensional covalent organic framework (3D COF), which can undergo a reversible transformation through a hydroquinone/quinone redox reaction while retaining the crystallinity and porosity. Our results clearly show that the switching process gradually happened through the COF framework, with an almost quantitative conversion yield. In addition, the redox-triggered transformation will form different functional groups on the pore surface and modify the shape of pore channel, which can result in tunable gas separation property. This study strongly demonstrates 3D COFs can provide robust platforms for efficient tuning of molecular switches in solid state. More importantly, switching of these moieties in 3D COFs can remarkably modify the internal pore environment, which will thus enable the resulting materials with interesting stimuli-responsive properties.

Self-assembly of stimuli-responsive block copolymers in aqueous solutions: an overview

2019 ◽  
Vol 77 (11) ◽  
pp. 5783-5810 ◽  
Author(s):  
Mehul Khimani ◽  
Hiren Patel ◽  
Vijay Patel ◽  
Paresh Parekh ◽  
Rohit L. Vekariya
Keyword(s):  
Block Copolymers ◽  
Aqueous Solutions ◽  
Self Assembly ◽  
Stimuli Responsive
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