Recent progress in selenium-catalyzed organic reactions

2019 ◽  
Vol 6 (16) ◽  
pp. 2999-3041 ◽  
Author(s):  
Lixiong Shao ◽  
Yiming Li ◽  
Jianmei Lu ◽  
Xuefeng Jiang
Keyword(s):  
Organic Synthesis ◽  
Recent Progress ◽  
Recent Decade ◽  
Organic Reactions

Selenium-based catalysts, including organo- and inorganoselenium ones, in organic synthesis in the recent decade are reviewed.

O-AcylTEMPOs, a Modified and Fundamental, but Unexplored Carboxylic Derivative: Recent Progress in Synthetic Applications

2019 ◽  
Vol 23 (19) ◽  
pp. 2102-2121
Author(s):  
Hiroyuki Kawafuchi ◽  
Lijian Ma ◽  
Md Imran Hossain ◽  
Tsutomu Inokuchi
Keyword(s):  
Organic Synthesis ◽  
Recent Progress ◽  
Knoevenagel Condensation ◽  
Acid Synthesis ◽  
Amino Acid Synthesis ◽  
Electrophilic Amination ◽  
Weinreb Amides ◽  
Anionic Species ◽  
Diastereoselective Addition ◽  
Carbonyl Function

O-Acylated 2,2,6,6-tetramethylpiperidine-N-oxyls (abbr. O-AcylTEMPOs) are easily available and stable carboxylic derivatives, but their utility in organic synthesis is unexplored in contrast to analogues, such as the N-methoxy-N-methylamides, known as Weinreb amides. Especially, the O–N unit of the O-acylTEMPOs dictates a fairly electronwithdrawing character for the carbonyl function. This enhances the reactivity and stability of the resulting enolate ions. Accordingly, O-acylTEMPOs allow various transformations and this review encompasses seven topics: (1) Reactivity of O-acylTEMPOs towards nucleophiles and chemoselective transformations, (2) Reactivity of anionic species derived from O-acylTEMPOs, (3) E-Selective Knoevenagel condensation of acetoacetylTEMPOs and synthesis of furans, (4) Electrocyclization of 2,4-dienones derived from acetoacetic derivatives and 2-substituted enals, (5) Diastereoselective addition of amide anion to O-(2-alkenoyl)TEMPOs and β-amino acid synthesis, (6) Thermolysis of O-acylTEMPOs, and (7) Applications for Umpolung reactions using O-benzoylTEMPOs, useful for the electrophilic amination of alkenes and alkynes.

The molecular diversity of 1,8-diaminonaphthalene in organic chemistry

2020 ◽  
Vol 23 ◽  
Author(s):  
Ghodsi Mohammadi Ziarani ◽  
Fatemeh Mohajer ◽  
Suraj N. Mali
Keyword(s):  
Organic Chemistry ◽  
Organic Synthesis ◽  
Molecular Diversity ◽  
Organic Reactions ◽  
Recent Application ◽  
Organic Structure

: 1,8-diaminonaphthalene (1,8-DAN) with special organic structure was applied in organic synthesis to provide efficient complex scaffolds, through the two or four-component fashion. This review highlights its recent application in organic reactions under different conditions and heterogynous catalysts to produce various molecules, which were used as medicines, sensors, and dyes.

scholarly journals An integrated console for capsule-based, automated organic synthesis

2021 ◽  
Author(s):  
Tuo Jiang ◽  
Samuele Bordi ◽  
Angus E. McMillan ◽  
Kuang-Yen Chen ◽  
Fumito Saito ◽  
...  
Keyword(s):  
Operating System ◽  
Organic Synthesis ◽  
User Involvement ◽  
Organic Reactions ◽  
Complex Organic

Using a combination of reagent design, hardware engineering, and a simple operating system we provide an instrument capable of executing complex organic reactions using prepacked capsules with minimal user involvement.

scholarly journals Non-Enzymatic Desymmetrization Reactions in Aqueous Media

Symmetry ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 720
Author(s):  
Satomi Niwayama
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Functional Groups ◽  
Organic Compounds ◽  
Recent Progress ◽  
Aqueous Media ◽  
Building Blocks ◽  
Organic Reactions ◽  
Environmentally Benign ◽  
Enzymatic Desymmetrization

Symmetric organic compounds are generally obtained inexpensively, and therefore they can be attractive building blocks for the total synthesis of various pharmaceuticals and natural products. The drawback is that discriminating the identical functional groups in the symmetric compounds is difficult. Water is the most environmentally benign and inexpensive solvent. However, successful organic reactions in water are rather limited due to the hydrophobicity of organic compounds in general. Therefore, desymmetrization reactions in aqueous media are expected to offer versatile strategies for the synthesis of a variety of significant organic compounds. This review focuses on the recent progress of desymmetrization reactions of symmetric organic compounds in aqueous media without utilizing enzymes.

A review of the recent progress on heterogeneous catalysts for Knoevenagel condensation

2021 ◽  
Vol 50 (13) ◽  
pp. 4445-4469
Author(s):  
Jimmy Nelson Appaturi ◽  
Rajni Ratti ◽  
Bao Lee Phoon ◽  
Samaila Muazu Batagarawa ◽  
Israf Ud Din ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Green Chemistry ◽  
Heterogeneous Catalysts ◽  
Recent Progress ◽  
Knoevenagel Condensation ◽  
Sustainable Production ◽  
Organic Reactions ◽  
Synthetic Organic Chemistry

One of the most crucial attributes of synthetic organic chemistry is to design organic reactions under the facets of green chemistry for the sustainable production of chemicals.

The Molecular Diversity Scope of Oxindole derivatives in Organic Synthesis.

2021 ◽  
Vol 25 ◽  
Author(s):  
Ghodsi Mohammadi Ziarani ◽  
Fatemeh Javadi ◽  
Fatemeh Mohajer
Keyword(s):  
Organic Chemistry ◽  
Organic Synthesis ◽  
Molecular Diversity ◽  
Biological Properties ◽  
Organic Reactions ◽  
Microbial Properties ◽  
Anti Cancer

: The role of oxindole derivatives is discussed as starting materials in diverse organic reactions including two and more components between the years 2014 until 2020. Oxindoles are famous because of their biological properties for instance chromanone-fused polycyclic pyrrolidinyl-dispirooxindoles, functionalized polycyclic spiro-fused carbocyclicoxindole, and 3,3-disubstituted oxindoles have anti-cancer, anti-tumor, and anti-microbial properties, respectively. Therefore, various methods for synthesizing the oxindole structures have received more attention in organic chemistry.

USE OF FACTORIAL DESIGN IN OPTIMIZATION OF MICROWAVE ASSISTED ORGANIC SYNTHESIS OF SOME AZOLES

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (10) ◽  
pp. 24-33
Author(s):  
R. R Somani ◽  
◽  
G. J. Sanap ◽  
P. K Chaskar
Keyword(s):  
Factorial Design ◽  
Organic Synthesis ◽  
Maximum Yield ◽  
Minimum Time ◽  
Organic Reactions ◽  
Design Approach ◽  
Environment Friendly ◽  
Microwave Assisted ◽  
Synthetic Reactions ◽  
32 Factorial Design

In the era of environment friendly chemistry, Microwave Assisted Organic Synthesis (MAOS) has proved to be an effective tool to achieve maximum yield in minimum time without compromising on quality. The present work focuses on synthesis of some bioactive heterocyclic azoles using MAOS. However, the synthetic reactions are optimized using a known technique of factorial designing. Here, 32 factorial design approach is used to achieve the set targets of yields and purity. The outcome has been very promising and opens up new avenues for organic chemists who face challenges in optimizing organic reactions.

Tin-Mediated Radical Cyclization Reactions

2021 ◽  
Vol 25 ◽  
Author(s):  
Saima malik ◽  
Aditya G. Lavekar ◽  
Bimal Krishna Banik
Keyword(s):  
Organic Compounds ◽  
Organic Synthesis ◽  
Biological Significance ◽  
Radical Cyclization ◽  
Organic Reactions ◽  
Cyclization Reactions ◽  
Complex Molecules ◽  
Radical Chemistry ◽  
Wide Range

: The radical was first come into existence in 1900 by Gomberg, where the triphenylmethane radical was explored. Thus, even to date, two centuries have seen radical chemistry as the methodology of preference in organic synthesis. Due to the fascinating nature of the radical-mediated cyclization reactions, it always caught the eye of organic chemists for the synthesis of novel organic compounds with diverse stereochemistry. Moreover, the development of radical methods further proves beneficial for the synthesis by providing atom- and step-economical methods to complex molecules. Among these, where radical chemistry has been employed, the use of tin-based radical annulation is the most common and widely used field for the synthesis of a wide range of organic reactions with medicinal importance. In this review, we compiled recent tin-mediated radical cyclization reactions toward the synthesis of molecules of biological significance.

7 Electrochemically Generated Nitrogen-Centered Radicals

2022 ◽  
Author(s):  
Z.-W. Hou ◽  
H.-C. Xu
Keyword(s):  
Hydrogen Atom ◽  
Organic Synthesis ◽  
Recent Progress ◽  
Reactive Intermediates ◽  
Hydrogen Atom Abstraction ◽  
Addition Reactions ◽  
Electrochemical Generation ◽  
Nitrogen Containing Compounds

Nitrogen-centered radicals are versatile reactive intermediates for organic synthesis. This chapter describes recent progress in the electrochemical generation and reactions of nitrogen-centered radicals. Under electrochemical conditions, various nitrogen-centered radicals are generated through electrolysis of readily available precursors such as N—H bonds or azides. These reactive intermediates undergo addition reactions to π-systems or hydrogen-atom abstraction to generate various nitrogen-containing compounds.

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