Enzyme immobilisation on poly-l-lysine-containing calcium phosphate particles for highly sensitive glucose detection

A novel electrochemical glucose sensor was developed, based on a multiwall carbon nanotubes (MWCNTs)-copper-1,3,5-benzenetricarboxylic acid (CuBTC)-epoxy composite electrode, named MWCNT-CuBTC. The electrode nanocomposite was prepared by a two-roll mill procedure and characterized morphostructurally by scanning electron microscopy (SEM). The CuBTC formed defined crystals with a wide size distribution, which were well dispersed and embedded in the MWCNTs. Its electrical conductivity was determined by four-point probe contact (DC) conductivity measurements. The electroactive surface area, determined using cyclic voltammetry (CV), was found to be 6.9 times higher than the geometrical one. The results of the electrochemical measurements using CV, linear sweep voltammetry (LSV), differential pulse voltammetry (DPV), chronoamperometry (CA) and multiple pulse amperometry (MPA) showed that the MWCNT-CuBTC composite electrode displayed high electrocatalytic activity toward the oxidation of glucose and, as a consequence, very high sensitivity. The best sensitivity of 14,949 µAmM−1cm−1 was reached using MPA at the potential value of 0.6 V/SCE, which was much higher in comparison with other copper-based electrodes reported in the literature. The good analytical performance, low cost and simple preparation method make this novel electrode material promising for the development of an effective glucose sensor.

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A highly sensitive glucose sensor based on a gold nanoparticles/polyaniline/multi-walled carbon nanotubes composite modified glassy carbon electrode

New Journal of Chemistry ◽

10.1039/c7nj04327a ◽

2018 ◽

Vol 42 (14) ◽

pp. 11944-11953 ◽

Cited By ~ 24

Author(s):

Xinping Zeng ◽

Yazhou Zhang ◽

Xiling Du ◽

Yanfei Li ◽

Wenwei Tang

Keyword(s):

Carbon Nanotubes ◽

Gold Nanoparticles ◽

Glucose Sensor ◽

High Sensitivity ◽

Carbon Electrode ◽

Modified Glassy Carbon Electrode ◽

Highly Sensitive ◽

Multi Walled Carbon Nanotubes ◽

Application Potential ◽

Walled Carbon Nanotubes

The PTFE/GOx/AuNPs/PANI/MWCNTs/GCE glucose sensor possesses wide linear range, low detection limit, high sensitivity, which can measure the glucose in human serum and holds application potential.

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Electrospun porous La-Sr-Co-Ni-O nanofibers for highly sensitive non-enzymatic glucose detection

Materials Advances ◽

10.1039/d1ma00984b ◽

2022 ◽

Author(s):

Kasci D Pelucarte ◽

Tashi A Hatchell ◽

Gibin George ◽

Sivasankara Rao Ede ◽

Menuka Adhikari ◽

...

Keyword(s):

Metal Oxides ◽

Perovskite Structure ◽

High Sensitivity ◽

Environmental Applications ◽

Glucose Detection ◽

Glucose Biosensors ◽

Highly Sensitive ◽

Excellent Stability

Glucose biosensors are widely used for clinical, industrial, and environmental applications. Nonenzymatic electrochemical glucose biosensors based on metal oxides with a perovskite structure have exhibited high sensitivity, excellent stability, and...

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Co3O4 Nanoparticles as a Noninvasive Electrochemical Sensor for Glucose Detection in Saliva

NANO ◽

10.1142/s1793292021500090 ◽

2020 ◽

pp. 2150009

Author(s):

Mei Wang ◽

Fang Liu ◽

Zhifeng Zhang ◽

Erchao Meng ◽

Feilong Gong ◽

...

Keyword(s):

Glucose Sensor ◽

Saliva Sample ◽

High Sensitivity ◽

Single Step ◽

Uniform Structure ◽

Glucose Detection ◽

Co3o4 Nanoparticles ◽

Glucose Levels ◽

Maximal Sensitivity ◽

Sensitivity And Selectivity

A new noninvasive glucose sensor is developed based on Co3O4 particles (Co3O4 NPs), which are synthesized by a single-step hydrothermal method with uniform structure and size. The electrochemical measurements reveal that the device exhibits outstanding performance for glucose detection, achieving a maximal sensitivity of 2495.79[Formula: see text][Formula: see text]A mM[Formula: see text] cm[Formula: see text] with a high [Formula: see text] of 0.99575, a ultra-low detection limit of 9.3[Formula: see text]nM with a signal-to-noise of 3 and linear range up to 3[Formula: see text]mM. The noninvasive glucose sensor can respond swiftly and selectively due to the high electrocatalytic activity of Co3O4 NPs. The sensor also shows its high sensitivity and selectivity in detecting glucose levels in human blood serum and saliva sample, confirming the application potential of Co3O4 NPs in noninvasive detection of glucose.

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Nanostructured copper selenide as an ultrasensitive and selective non-enzymatic glucose sensor

Materials Advances ◽

10.1039/d0ma00890g ◽

2021 ◽

Author(s):

Siddesh Umapathi ◽

Harish Singh ◽

Jahangir Masud ◽

Manashi Nath

Keyword(s):

Detection Limit ◽

High Efficiency ◽

Glucose Sensor ◽

High Sensitivity ◽

Copper Selenide ◽

Glucose Detection ◽

Applied Potential ◽

Detection Range ◽

Low Detection Limit ◽

Linear Detection

CuSe nanostructures exhibit high-efficiency for glucose detection with high sensitivity (19.419 mA mM−1 cm−2) and selectivity at low applied potential (0.15 V vs. Ag|AgCl), low detection limit (0.196 μM) and linear detection range (100 nM to 40 μM).

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Solvothermal synthesis of Fe3O4 nanospheres for high-performance electrochemical non-enzymatic glucose sensor

Scientific Reports ◽

10.1038/s41598-020-73090-4 ◽

2020 ◽

Vol 10 (1) ◽

Cited By ~ 1

Author(s):

Jiasheng Xu ◽

Yuting Sun ◽

Jie Zhang

Keyword(s):

Active Sites ◽

High Performance ◽

Glucose Sensor ◽

Limit Of Detection ◽

Glucose Monitoring ◽

High Sensitivity ◽

Blood Glucose Monitoring ◽

Glucose Detection ◽

Uniform Size ◽

Long Term Stability

Abstract Ferroferric oxide (Fe3O4) nanospheres have been synthesized via a facile solvothermal procedure to serve as an electrode material for high performance non-enzymatic glucose sensor. The as-synthesized Fe3O4 nanospheres with a uniform size from 16 to 18 nm, which can increase the reaction contact area and the active sites in the process of glucose detection. Benefiting from the particular nanoscale structure, the Fe3O4 nanospheres obviously enhanced the activity of electrocatalytic oxidation towards glucose. When the Fe3O4 nanospheres material was used for non-enzymatic glucose sensor, several electrochemical properties including the high sensitivity 6560 μA mM−1 cm−2 (0.1–1.1 mM), limit of detection 33 μM (S/N = 3) and good long-term stability were well demonstrated. Furthermore, Fe3O4 nanospheres electrode confirmed the excellent performance of selectivity in glucose detection with the interfering substances existed such as urea, citric acid, ascorbic acid, and NaCl. Due to the excellent electrocatalytic activity in alkaline solution, the Fe3O4 nanospheres material can be considered as a promising candidate in blood glucose monitoring.

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Preparation of Ni(OH)2 nanosheets on Ni foam via a direct precipitation method for a highly sensitive non-enzymatic glucose sensor

RSC Advances ◽

10.1039/c5ra06664f ◽

2015 ◽

Vol 5 (66) ◽

pp. 53665-53670 ◽

Cited By ~ 17

Author(s):

Yudong Zhao ◽

Gaochen Gu ◽

Shengquan You ◽

Renhua Ji ◽

Hui Suo ◽

...

Keyword(s):

Glucose Concentration ◽

Glucose Sensor ◽

High Sensitivity ◽

Precipitation Method ◽

Ni Foam ◽

Direct Precipitation ◽

Highly Sensitive ◽

Direct Precipitation Method

Ni(OH)2 nanosheets on Ni foam was prepared by the direct precipitation method. This electrode shows high sensitivity with 1130 μA mM−1 cm−2 at the glucose concentration range of 2 μM to 40 μM and 1097 μA mM−1 cm−2 at the range of 0.1 mM to 2.5 mM.

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Ternary NiCoP nanosheet array on a Ti mesh: a high-performance electrochemical sensor for glucose detection

Chemical Communications ◽

10.1039/c6cc08078b ◽

2016 ◽

Vol 52 (100) ◽

pp. 14438-14441 ◽

Cited By ~ 74

Author(s):

Zao Wang ◽

Xiaoqin Cao ◽

Danni Liu ◽

Shuai Hao ◽

Gu Du ◽

...

Keyword(s):

High Performance ◽

Glucose Sensor ◽

Active Catalyst ◽

High Sensitivity ◽

Alkaline Media ◽

Glucose Detection ◽

Nanosheet Array ◽

Electro Oxidation ◽

Ti Mesh ◽

Catalyst Electrode

NiCoP nanosheet array acts as a high-active catalyst electrode for glucose electro-oxidation in alkaline media. As a non-enzyme electrochemical glucose sensor, it shows a low detection limit of 0.13 μM (S/N = 3) and a high sensitivity of 14 586 μA mM−1 cm−2.

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Low-cost and high sensitivity glucose sandwich detection using a plasmonic nanodisk metasurface

Nanoscale ◽

10.1039/d0nr00288g ◽

2020 ◽

Vol 12 (19) ◽

pp. 10809-10815 ◽

Cited By ~ 1

Author(s):

Zhongwen Long ◽

Yuzhang Liang ◽

Lei Feng ◽

Hui Zhang ◽

Mingze Liu ◽

...

Keyword(s):

Large Scale ◽

Low Cost ◽

High Sensitivity ◽

Glucose Detection ◽

Sensing Platform ◽

Highly Sensitive

A low-cost, large scale plasmonic metasurface sensing platform shows enormous potential for highly sensitive and selective SERS-based glucose detection.

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An enzymatic glucose detection sensor using ZnO nanostructure

MRS Advances ◽

10.1557/adv.2016.100 ◽

2016 ◽

Vol 1 (13) ◽

pp. 847-853 ◽

Cited By ~ 2

Author(s):

Mohammed Marie ◽

Sanghamitra Mandal ◽

Omar Manasreh

Keyword(s):

Glucose Sensor ◽

Limit Of Detection ◽

Sol Gel ◽

Zno Nanorods ◽

High Sensitivity ◽

High Density ◽

Glucose Detection ◽

Zno Nanostructure ◽

Growth Method ◽

Gel Technique

Abstract:Glucose sensor based on ITO/ZnO NRs/GOx/nafion is fabricated and tested under different glucose concentrations. Hydrothermal growth method along with sol-gel technique is used to grow high quality ZnO nanorods that have well-alignment and high density with an acceptable aspect ratio. The as-grown of ZnO nanorods are used to fabricate a working electrode that can be used for glucose detection in blood after a modification process with GOx and nafion membrane. Annealing at 110 °C helped in improves the crystallinity of the seed layer and as a result, a high density and well alignment as-grown ZnO nanorods were obtained. High sensitivity and short response time were obtained from the fabricated device with an acceptable lower limit of detection.

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