Co3O4 Nanoparticles as a Noninvasive Electrochemical Sensor for Glucose Detection in Saliva

A new noninvasive glucose sensor is developed based on Co3O4 particles (Co3O4 NPs), which are synthesized by a single-step hydrothermal method with uniform structure and size. The electrochemical measurements reveal that the device exhibits outstanding performance for glucose detection, achieving a maximal sensitivity of 2495.79[Formula: see text][Formula: see text]A mM[Formula: see text] cm[Formula: see text] with a high [Formula: see text] of 0.99575, a ultra-low detection limit of 9.3[Formula: see text]nM with a signal-to-noise of 3 and linear range up to 3[Formula: see text]mM. The noninvasive glucose sensor can respond swiftly and selectively due to the high electrocatalytic activity of Co3O4 NPs. The sensor also shows its high sensitivity and selectivity in detecting glucose levels in human blood serum and saliva sample, confirming the application potential of Co3O4 NPs in noninvasive detection of glucose.

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Non-Enzymatic Amperometric Glucose Sensor Based on Carbon Nanodots and Copper Oxide Nanocomposites Electrode

Sensors ◽

10.3390/s20030808 ◽

2020 ◽

Vol 20 (3) ◽

pp. 808 ◽

Cited By ~ 10

Author(s):

Tharinee Sridara ◽

Jantima Upan ◽

Gopalan Saianand ◽

Adisorn Tuantranont ◽

Chanpen Karuwan ◽

...

Keyword(s):

Copper Oxide ◽

Glucose Sensor ◽

Research Work ◽

Chemical Properties ◽

High Sensitivity ◽

Alkaline Solutions ◽

Carbon Nanodots ◽

Glucose Detection ◽

Sensing Platform ◽

Sensitivity And Selectivity

In this research work, a non-enzymatic amperometric sensor for the determination of glucose was designed based on carbon nanodots (C-dots) and copper oxide (CuO) nanocomposites (CuO-C-dots). The CuO-C-dots nanocomposites were modified on the surface of a screen-printed carbon electrode (SPCE) to increase the sensitivity and selectivity of the glucose sensor. The as-synthesized materials were further analyzed for physico-chemical properties through characterization tools such as transmission electron microscopy (TEM) and Fourier-transform infrared spectroscopy (FTIR); and their electrochemical performance was also studied. The SPCE modified with CuO-C-dots possess desirable electrocatalytic properties for glucose oxidation in alkaline solutions. Moreover, the proposed sensing platform exhibited a linear range of 0.5 to 2 and 2 to 5 mM for glucose detection with high sensitivity (110 and 63.3 µA mM−1cm−2), and good selectivity and stability; and could potentially serve as an effective alternative method of glucose detection.

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Non-enzymatic glucose detection using nitrogen-doped diamond-like carbon electrodes modified with gold nanoclusters

Pure and Applied Chemistry ◽

10.1351/pac-con-09-11-11 ◽

2010 ◽

Vol 82 (11) ◽

pp. 2217-2229 ◽

Cited By ~ 13

Author(s):

Aiping Liu ◽

Erjia Liu ◽

Guocheng Yang ◽

Nay Win Khun ◽

Wenguang Ma

Keyword(s):

Photoelectron Spectroscopy ◽

Gold Nanoclusters ◽

High Sensitivity ◽

Vacuum Arc ◽

Diabetic Patients ◽

Diamond Like Carbon ◽

Glucose Detection ◽

Detection Range ◽

Nitrogen Doped ◽

Glucose Levels

Highly sensitive electrochemical electrodes for glucose detection were developed by using Au nanoclusters (NCs) to modify nitrogen-doped diamond-like carbon thin films (DLC:N/Au). The DLC:N/Au electrodes were prepared with a filtered cathodic vacuum arc process followed by electrodeposition and characterized by X-ray photoelectron spectroscopy, Raman spectroscopy, and scanning electron microscopy. The size of the Au NCs covered by Au oxide ranged between 10 and 70 nm with a density of 108–109 clusters per cm2. Glucose oxidation at the DLC:N/Au electrodes started from about –0.5 V due to the high catalytic activities of the Au NCs in NaOH solutions, and the catalytic ability of the electrodes depended on the amount of Au NCs deposited on the electrode surfaces. A linear detection range of glucose with the DLC:N/Au electrodes was identified from about 0.25 to 30 mM (covering blood glucose levels in diabetic patients) with a detection limit of 60 μM. The experimental results showed that the non-enzymatic glucose sensors based on the DLC:N/Au electrodes had high sensitivity and good reproducibility and stability.

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Nanostructured copper selenide as an ultrasensitive and selective non-enzymatic glucose sensor

Materials Advances ◽

10.1039/d0ma00890g ◽

2021 ◽

Author(s):

Siddesh Umapathi ◽

Harish Singh ◽

Jahangir Masud ◽

Manashi Nath

Keyword(s):

Detection Limit ◽

High Efficiency ◽

Glucose Sensor ◽

High Sensitivity ◽

Copper Selenide ◽

Glucose Detection ◽

Applied Potential ◽

Detection Range ◽

Low Detection Limit ◽

Linear Detection

CuSe nanostructures exhibit high-efficiency for glucose detection with high sensitivity (19.419 mA mM−1 cm−2) and selectivity at low applied potential (0.15 V vs. Ag|AgCl), low detection limit (0.196 μM) and linear detection range (100 nM to 40 μM).

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Study of Glucose Binding Protein Encapsulated Gold Nanoclusters by Molecular Dynamic Simulation

Materials Science Forum ◽

10.4028/www.scientific.net/msf.948.133 ◽

2019 ◽

Vol 948 ◽

pp. 133-139

Author(s):

Boy Marsaputra Panjaitan ◽

Karina Kubiak-Ossowska ◽

David Birch ◽

Yu Chen

Keyword(s):

Md Simulation ◽

Glucose Sensor ◽

Binding Protein ◽

Gold Nanoclusters ◽

High Sensitivity ◽

Nucleation Site ◽

Fluorescent Properties ◽

Glucose Binding ◽

Sensitivity And Selectivity ◽

Glucose Binding Protein

Protein encapsulated gold nanoclusters has attracted great attention for their excellent fluorescent properties and potential biomedical applications. Glucose Binding Protein (GBP) has a high sensitivity and selectivity to glucose binding that makes them ideal for biosensor development. It is anticipated that GBP encapsulated gold nanoclusters could be a promising glucose sensor. Here we investigated the growth of gold nanoclusters in GBP using Molecular Dynamics (MD) simulation. To facilitation the nucleation of gold nanoclusters at specific sites, cysteine mutations were introduced in GBP. It is found that the nucleation site of gold nanoclusters inside mutant GBP are different from those in native GBP. Gold nanoclusters were formed near the mutated cysteine and tyrosine residues. Glucose remained in the binding site of a mutant GBP with gold nanoclusters although no conformational change was observed in MD simulation, similar to a native GBP. This work suggests the possibility of growing gold nanoclusters in the designed site within GBP and a new glucose sensor based on mutated GBP protected gold nanoclusters.

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Solvothermal synthesis of Fe3O4 nanospheres for high-performance electrochemical non-enzymatic glucose sensor

Scientific Reports ◽

10.1038/s41598-020-73090-4 ◽

2020 ◽

Vol 10 (1) ◽

Cited By ~ 1

Author(s):

Jiasheng Xu ◽

Yuting Sun ◽

Jie Zhang

Keyword(s):

Active Sites ◽

High Performance ◽

Glucose Sensor ◽

Limit Of Detection ◽

Glucose Monitoring ◽

High Sensitivity ◽

Blood Glucose Monitoring ◽

Glucose Detection ◽

Uniform Size ◽

Long Term Stability

Abstract Ferroferric oxide (Fe3O4) nanospheres have been synthesized via a facile solvothermal procedure to serve as an electrode material for high performance non-enzymatic glucose sensor. The as-synthesized Fe3O4 nanospheres with a uniform size from 16 to 18 nm, which can increase the reaction contact area and the active sites in the process of glucose detection. Benefiting from the particular nanoscale structure, the Fe3O4 nanospheres obviously enhanced the activity of electrocatalytic oxidation towards glucose. When the Fe3O4 nanospheres material was used for non-enzymatic glucose sensor, several electrochemical properties including the high sensitivity 6560 μA mM−1 cm−2 (0.1–1.1 mM), limit of detection 33 μM (S/N = 3) and good long-term stability were well demonstrated. Furthermore, Fe3O4 nanospheres electrode confirmed the excellent performance of selectivity in glucose detection with the interfering substances existed such as urea, citric acid, ascorbic acid, and NaCl. Due to the excellent electrocatalytic activity in alkaline solution, the Fe3O4 nanospheres material can be considered as a promising candidate in blood glucose monitoring.

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Ternary NiCoP nanosheet array on a Ti mesh: a high-performance electrochemical sensor for glucose detection

Chemical Communications ◽

10.1039/c6cc08078b ◽

2016 ◽

Vol 52 (100) ◽

pp. 14438-14441 ◽

Cited By ~ 74

Author(s):

Zao Wang ◽

Xiaoqin Cao ◽

Danni Liu ◽

Shuai Hao ◽

Gu Du ◽

...

Keyword(s):

High Performance ◽

Glucose Sensor ◽

Active Catalyst ◽

High Sensitivity ◽

Alkaline Media ◽

Glucose Detection ◽

Nanosheet Array ◽

Electro Oxidation ◽

Ti Mesh ◽

Catalyst Electrode

NiCoP nanosheet array acts as a high-active catalyst electrode for glucose electro-oxidation in alkaline media. As a non-enzyme electrochemical glucose sensor, it shows a low detection limit of 0.13 μM (S/N = 3) and a high sensitivity of 14 586 μA mM−1 cm−2.

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An enzymatic glucose detection sensor using ZnO nanostructure

MRS Advances ◽

10.1557/adv.2016.100 ◽

2016 ◽

Vol 1 (13) ◽

pp. 847-853 ◽

Cited By ~ 2

Author(s):

Mohammed Marie ◽

Sanghamitra Mandal ◽

Omar Manasreh

Keyword(s):

Glucose Sensor ◽

Limit Of Detection ◽

Sol Gel ◽

Zno Nanorods ◽

High Sensitivity ◽

High Density ◽

Glucose Detection ◽

Zno Nanostructure ◽

Growth Method ◽

Gel Technique

Abstract:Glucose sensor based on ITO/ZnO NRs/GOx/nafion is fabricated and tested under different glucose concentrations. Hydrothermal growth method along with sol-gel technique is used to grow high quality ZnO nanorods that have well-alignment and high density with an acceptable aspect ratio. The as-grown of ZnO nanorods are used to fabricate a working electrode that can be used for glucose detection in blood after a modification process with GOx and nafion membrane. Annealing at 110 °C helped in improves the crystallinity of the seed layer and as a result, a high density and well alignment as-grown ZnO nanorods were obtained. High sensitivity and short response time were obtained from the fabricated device with an acceptable lower limit of detection.

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Label-Free Glucose Detection Using Cantilever Sensor Technology Based on Gravimetric Detection Principles

Journal of Analytical Methods in Chemistry ◽

10.1155/2013/687265 ◽

2013 ◽

Vol 2013 ◽

pp. 1-5 ◽

Cited By ~ 7

Author(s):

Shuchen Hsieh ◽

Shu-Ling Hsieh ◽

Chiung-wen Hsieh ◽

Po-Chiao Lin ◽

Chun-Hsin Wu

Keyword(s):

Specific Interaction ◽

High Sensitivity ◽

Sensor Technology ◽

Glucose Detection ◽

Label Free ◽

Con A ◽

Cantilever Sensor ◽

Sensitivity And Selectivity ◽

Free Glucose ◽

Afm Cantilever

Efficient maintenance of glucose homeostasis is a major challenge in diabetes therapy, where accurate and reliable glucose level detection is required. Though several methods are currently used, these suffer from impaired response and often unpredictable drift, making them unsuitable for long-term therapeutic practice. In this study, we demonstrate a method that uses a functionalized atomic force microscope (AFM) cantilever as the sensor for reliable glucose detection with sufficient sensitivity and selectivity for clinical use. We first modified the AFM tip with aminopropylsilatrane (APS) and then adsorbed glucose-specific lectin concanavalin A (Con A) onto the surface. The Con A/APS-modified probes were then used to detect glucose by monitoring shifts in the cantilever resonance frequency. To confirm the molecule-specific interaction, AFM topographical images were acquired of identically treated silicon substrates which indicated a specific attachment for glucose-Con A and not for galactose-Con A. These results demonstrate that by monitoring the frequency shift of the AFM cantilever, this sensing system can detect the interaction between Con A and glucose, one of the biomolecule recognition processes, and may assist in the detection and mass quantification of glucose for clinical applications with very high sensitivity.

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High-performance non-enzymatic glucose detection: using a conductive Ni-MOF as an electrocatalyst

Journal of Materials Chemistry B ◽

10.1039/d0tb00131g ◽

2020 ◽

Vol 8 (25) ◽

pp. 5411-5415 ◽

Cited By ~ 10

Author(s):

Yanxia Qiao ◽

Qian Liu ◽

Siyu Lu ◽

Guang Chen ◽

Shuyan Gao ◽

...

Keyword(s):

Detection Limit ◽

Response Time ◽

Blood Serum ◽

High Performance ◽

Glucose Sensor ◽

High Sensitivity ◽

Fast Response ◽

Glucose Detection ◽

Serum Samples ◽

Fast Response Time

A glucose sensor based on a conductive Ni-MOF as an electrocatalyst exhibits a fast response time, low detection limit, and high sensitivity, and it can also be applied for the detection of glucose in blood serum samples.

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