scholarly journals The protective potential of a Fraxinus xanthoxyloides ethyl acetate fraction against CCl4-induced oxidative stress in the cardiac tissue of rats

RSC Advances ◽  
2020 ◽  
Vol 10 (17) ◽  
pp. 10221-10231
Author(s):  
Tahira Younis ◽  
Faiza Jabeen ◽  
Laila Jafri ◽  
Azhar Rasul ◽  
Maleeha Manzoor ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Diseases ◽  
Medicinal Plants ◽  
Secondary Metabolites ◽  
Ethyl Acetate ◽  
Cardiac Tissue ◽  
Ethyl Acetate Fraction ◽  
Protective Potential ◽  
Golden Opportunity

Secondary metabolites present in medicinal plants offer a golden opportunity to fight different ailments, such as cancer, infections, diabetes, neurodegenerative and cardiovascular diseases, etc.

Harpagophytum Procumbens Ethyl Acetate Fraction Reduces Fluphenazine-Induced Vacuous Chewing Movements and Oxidative Stress in Rat Brain

2016 ◽  
Vol 41 (5) ◽  
pp. 1170-1184 ◽  
Author(s):  
Larissa Finger Schaffer ◽  
Catiuscia Molz de Freitas ◽  
Ana Paula Chiapinotto Ceretta ◽  
Luis Ricardo Peroza ◽  
Elizete de Moraes Reis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ethyl Acetate ◽  
Rat Brain ◽  
Ethyl Acetate Fraction ◽  
Vacuous Chewing Movements ◽  
Harpagophytum Procumbens ◽  
Vacuous Chewing ◽  
And Oxidative Stress

scholarly journals The Effect of Ethanol and Ethyl Acetate Fraction of Chayote fruit (Sechium edule Jacq. Swartz) on the Oxidative Stress and Insulin Resistance of Male White Rat Model Type 2 Diabetes Mellitus

2020 ◽  
Vol 8 (A) ◽  
pp. 962-969
Author(s):  
Jekson Martiar Siahaan ◽  
Syaffruddin Illyas ◽  
Dharma Lindarto ◽  
Marline Nainggolan
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Ethyl Acetate ◽  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Insulin Level ◽  
Ethyl Acetate Fraction ◽  
Sechium Edule

BACKGROUND: Oxidative stress in type 2 diabetes mellitus (T2D) causes insulin resistance and disordered insulin secretion. Pathomechanisms of T2D consist of dysfunctional pancreatic β-cell and insulin resistance caused by free radical (reactive oxygen species and reactive nitrogen species) that produced from the glucose metabolism pathway. Insulin resistance can be measured using the homeostatic model assessment of insulin resistance (HOMA-IR). Oxidative stress can measure through the activities of malondialdehyde (MDA) and superoxide dismutase (SOD). AIM: This research aims to study the potential of chayote (Sechium edule Jacq. Swartz) to be used as antihyperglycemic in T2D. MATERIALS AND METHODS: This research was conducted with a post-test randomized controlled group design. Eleven groups with four male rats each were used. Normal untreated rats were treated under ad libitum feeding and drinking condition. Meanwhile, the rat models were induced with the combination of 45 mg/kg b.w. streptozotocin, 110 mg/kg b.w. nicotinamide, 40.5 mg/kg b.w. metformin, high-fat diet, and/or chayote extract. The chayote extract was orally administered to the rat in the form of ethanol extract and/or ethyl acetate fraction, with three dosages of 45 mg/kg b.w., 100 mg/kg b.w., and 150 mg/kg b.w. for each extract type. The body weight, glucose level, insulin level, MDA, and SOD activities were measured. The HOMA-IR was used. RESULTS: The lowest body weight of the rat model in week 0 was 145 ± 25.31, founded in Group H that was treated with ethyl acetate fraction of chayote extract (45 mg/kg b.w.). The lowest blood sugar level in the group with 2 h glucose load was 112.5 ± 27.00 on average, found in Group G that was treated with chayote ethanolic extract (150 mg/kg b.w.). The highest SOD in the group treated with chayote extract was 1.27 ± 0.20, founded in Group H treated with ethyl acetate 45 mg/kg b.w. The lowest level of MDA was 0.86 ± 0.70 in Group H treated with ethyl acetate 45 mg/kg b.w. The lowest fasting blood sugar spectrophotometer level was 150.54 ± 17.24 mg/dl in Group K with metformin treatment, followed by 155.16 ± 31.92 mg/dl in Group K treated 45 mg/kg b.w. ethanol treatment. The highest insulin level was 6.14 ± 0.71, founded in Group F that was treated with chayote ethanolic extract 100 mg/kg b.w. The lowest measurement of HOMA-IR was 0.16 ± 0.80 in Group E treated with ethanol extract of chayote 45 mg/kg b.w. CONCLUSION: Ethanol extract and fractionation of chayote work as an antioxidant and anti-insulin resistance.

Ethyl-acetate fraction of Trichilia catigua restores long-term retrograde memory and reduces oxidative stress and inflammation after global cerebral ischemia in rats

2018 ◽  
Vol 337 ◽  
pp. 173-182 ◽  
Author(s):  
Jacqueline Godinho ◽  
Rúbia Maria Weffort de Oliveira ◽  
Anacharis Babeto de Sa-Nakanishi ◽  
Cristiano Correia Bacarin ◽  
Claudia Hitomi Huzita ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cerebral Ischemia ◽  
Ethyl Acetate ◽  
Ethyl Acetate Fraction ◽  
Global Cerebral Ischemia ◽  
Retrograde Memory

scholarly journals Ethyl-acetate fraction of Trichilia catigua protects against oxidative stress and neuroinflammation after cerebral ischemia/reperfusion

2018 ◽  
Vol 221 ◽  
pp. 109-118 ◽  
Author(s):  
Jacqueline Godinho ◽  
Anacharis Babeto de Sa-Nakanishi ◽  
Lucas Stafuza Moreira ◽  
Rúbia Maria Weffort de Oliveira ◽  
Claudia Hitomi Huzita ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cerebral Ischemia ◽  
Ethyl Acetate ◽  
Ischemia Reperfusion ◽  
Ethyl Acetate Fraction ◽  
Cerebral Ischemia Reperfusion

Treatment with Trichilia catigua ethyl-acetate fraction improves healing and reduces oxidative stress in TNBS-induced colitis in rats

2018 ◽  
Vol 107 ◽  
pp. 194-202 ◽  
Author(s):  
Fernando Augusto Vicentini ◽  
Maiara Morselli Coelho Barbosa ◽  
Maísa Carla Fortunato ◽  
Ciomar Aparecida Bersani Amado ◽  
Jurandir Fernando Comar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ethyl Acetate ◽  
Ethyl Acetate Fraction

scholarly journals Effect of Extraction Methods on Antioxidant Activity of Papery Skin Extracts and Fractions of Maja Cipanas Onion (Allium cepa L. var. ascalonicum)

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Nyi M. Saptarini ◽  
Yulia Wardati
Keyword(s):  
Antioxidant Activity ◽  
Secondary Metabolites ◽  
Ethyl Acetate ◽  
Allium Cepa ◽  
Ethyl Acetate Fraction ◽  
Extraction Process ◽  
Extraction Methods ◽  
Water Fraction ◽  
Percolation Method ◽  
Soxhlet Method

Extraction can be carried out at ambient temperature or high temperature to accelerate the extraction process of secondary metabolites from simplicia. This study aimed to determine the effectiveness of extraction methods on antioxidant activity of secondary metabolites of papery skin extracts and fractions of Maja Cipanas onion (Allium cepa L. var. ascalonicum). Extraction methods were maceration, percolation, reflux, and Soxhlet method, and then, concentrated extracts were fractionated by liquid-liquid extraction based on the polarity of secondary metabolites. Antioxidant activity was determined by the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. The phytochemical screening showed that onion papery skin contained alkaloids, polyphenols, flavonoids, and tannins. The IC50 value of the extract, ethyl acetate fraction, and water fraction of the four extraction methods in the concentration range 25–400  μg/mL were in the range of 55.62–107.08, 31.31–84.06, and 126.05–139.82  μg/mL, respectively, while the IAA value was in the ranges of 0.25–0.49, 0.32–0.86, and 0.19–0.21, respectively. Variation in IC50 and IAA values indicate that the extraction method affects antioxidant activity, due to extracted secondary metabolites from simplicia. The highest antioxidant activity was an ethyl acetate fraction by the reflux method, while the lowest was water fraction by the percolation method.

scholarly journals IDENTIFICATION OF SECONDARY METABOLIC AND TEST OF ACTIVITY ETHYL ACETATE FRACTION OF BANGUN¬- BANGUN (Coleus amboinicus Lour.) LEAVES AS ANTIOXIDANT

2020 ◽  
Vol 7 (1) ◽  
pp. 117-122
Author(s):  
Kasta Gurning
Keyword(s):  
Antioxidant Activity ◽  
Secondary Metabolites ◽  
Ethyl Acetate ◽  
Oxidation Process ◽  
Natural Antioxidants ◽  
Ethyl Acetate Fraction ◽  
The Body ◽  
Synthetic Antioxidants ◽  
Dpph Method ◽  
Coleus Amboinicus

Antioxidants have an important role in delaying the oxidation process and preventing the occurrence of degenerative diseases in the body. Antioxidants consist of synthetic and natural; the use of synthetic antioxidants in a relatively long period is hazardous so that the use of natural antioxidants is considered more potential and safe for the body. The process of extracting secondary metabolites from the leaves of bangun-bangun (Coleus amboinicus L.) is carried out by the maceration method with methanol, then partitioned in stages with n-hexane, chloroform, and ethyl acetate. This research intends to identify secondary metabolites and test antioxidant activity from the ethyl acetate fraction with the DPPH method. Phytochemical screening results of ethyl acetate fraction showed the different secondary metabolite groups such as alkaloids, phenolics & polyphenols, flavonoids, coumarin, and triterpenoids. Antioxidant activity (IC50) obtained is 64.97 with a healthy category, so that the potential to be used as a natural antioxidant.

scholarly journals Reduksi Udema Kaki Mencit (Mus musculus) Terinduksi Karagenan Setelah Pemberian Ekstrak Daruju (Acanthus ilicifolius L.)

2020 ◽  
Vol 17 (2) ◽  
pp. 86-91
Author(s):  
Darul Ikhwan ◽  
Octavian Rachmadi ◽  
Annisa Dyah Astari Putri ◽  
Ari Widiyantoro
Keyword(s):  
Secondary Metabolites ◽  
Ethyl Acetate ◽  
Mus Musculus ◽  
Crude Extract ◽  
Antiinflammatory Activity ◽  
Raw Materials ◽  
Ethyl Acetate Fraction ◽  
West Kalimantan ◽  
Mangrove Plants ◽  
Acanthus Ilicifolius

Acanthus ilicifolius L. is one of the mangrove plants that contain a lot of potential secondary metabolites of medicinal raw materials. People of Sambas Regency of West Kalimantan Province uses leaves extract daruju to overcome the pain in the stiff and swollen. The objective of this study was to know the antiinflammatory activity of leaves extract of daruju, in the form of edema reduction of mices feet induced carrageenan. The method used in the form of maceration and partition extraction followed by phytochemical test of crude extract and the fraction of result of partition. Furthermore, the crude extract and the fraction of the result of the partition were tested for the reduction of edema mices feet induced carrageenan. The results showed that ethyl acetate fraction had the best antiinflammatory activity because it was able to decrease the edema of mices feet by 75% at 750 mg / kg BW. Ethyl acetate fraction has the ability to reduce edema because it contains group compounds of flavonoid and terpenoid.

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