Construction of multilayer films with bactericidal and long-term antitumor drug release properties as a non-vascular stent coating for therapy in obstruction

2019 ◽  
Vol 7 (32) ◽  
pp. 4963-4972 ◽  
Author(s):  
Xiao-yan Xu ◽  
Yan-fang Chen ◽  
Qing-gang Tan ◽  
Zhi-jie Chen ◽  
Yan Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Self Assembly ◽  
Multilayer Films ◽  
Antitumor Drug ◽  
Layer By Layer ◽  
Vascular Stent ◽  
Assembly Method ◽  
Stent Coating

An antibacterial and antitumor coating for non-vascular stent was constructed via the layer-by-layer electrostatic self-assembly method.

Fabrication of Antireflective Films Composed of High and Low Refractive Index Layers Using Layer-by-Layer Self-Assembly Method

2007 ◽  
Vol 124-126 ◽  
pp. 559-562
Author(s):  
Jin Hye Bae ◽  
Jin Han Cho ◽  
Kook Heon Char
Keyword(s):  
Refractive Index ◽  
Self Assembly ◽  
Annealing Temperature ◽  
High Refractive Index ◽  
Multilayer Films ◽  
Layer By Layer ◽  
Assembly Method ◽  
Particle Layer ◽  
Refractive Index Layer ◽  
Low Refractive Index

We introduce a novel and versatile approach for controlling anti-reflective (AR) properties of multilayer films based on layer-by-layer (LbL) self-assembly (SA) method. For the fabrication of these films, blend (i.e., mixed) layers containing both polyanions (i.e., titanium precursor (TALH) and poly(sodium 4-styrenesulfonate) (PSS)) were assembled with polycation (i.e., poly(diallyldimethylammonium chloride) (PDAD)) for the formation of the high refractive index multilayers and on the other hand, the negatively charged silica particles with the diameter of about 100 nm were employed for low refractive index layer. The refractive index of TALH:PSS/PDAD multilayer was controlled by blending ratio and annealing temperature as TALH has the relatively high refractive index (n = 1.68) in comparison with that (n = 1.46) of conventional polyelectrolytes (PEs) at room temperature and furthermore these titanium precursors are partially changed into TiO2 with relatively high refractive indices (n = 1.50 ~ 1.81) at annealing temperature of 250 oC. In the case of silica particle layer used for low refractive index layer, the calculated refractive index was about 1.35 due to much vacancy among the adsorbed silica colloids although the inherent refractive index of silica material is about 1.45. As a result, the films composed of TALH:PSS/PDAD multilayers with tunable refractive index and silica colloidal layer can easily modulate the optical properties of multilayer films by blending ratio and heat treatment.

Optical properties of polyelectrolyte quantum dot multilayer films prepared using the layer by layer self-assembly method

2008 ◽  
Vol 103 (8) ◽  
pp. 083511
Author(s):  
Emmanouil Lioudakis ◽  
Elena Koupanou ◽  
Constantina Kanari ◽  
Epameinondas Leontidis ◽  
Andreas Othonos
Keyword(s):  
Optical Properties ◽  
Quantum Dot ◽  
Self Assembly ◽  
Multilayer Films ◽  
Layer By Layer ◽  
Assembly Method

scholarly journals Influence of Elongation of Paclitaxel-Eluting Electrospun-Produced Stent Coating on Paclitaxel Release and Transport Through the Arterial Wall after Stenting

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1165
Author(s):  
Zhanna K. Nazarkina ◽  
Boris P. Chelobanov ◽  
Konstantin A. Kuznetsov ◽  
Alexey V. Shutov ◽  
Irina V. Romanova ◽  
...  
Keyword(s):  
Drug Release ◽  
Arterial Wall ◽  
Release Kinetics ◽  
Artery Wall ◽  
Vascular Stents ◽  
Drug Eluting ◽  
Fiber Breaks ◽  
Stent Diameter ◽  
Stent Coating

It was previously shown that polycaprolactone (PCL)-based electrospun-produced paclitaxel (PTX)-enriched matrices exhibit long-term drug release kinetics and can be used as coatings for drug-eluting stents (DES). The installation of vascular stents involves a twofold increase in stent diameter and, therefore, an elongation of the matrices covering the stents, as well as the arterial wall in a stented area. We studied the influence of matrix elongation on its structure and PTX release using three different electrospun-produced matrices. The data obtained demonstrate that matrix elongation during stent installation does not lead to fiber breaks and does not interfere with the kinetics of PTX release. To study PTX diffusion through the expanded artery wall, stents coated with 5%PCL/10%HSA/3%DMSO/PTX and containing tritium-labeled PTX were installed into the freshly obtained iliac artery of a rabbit. The PTX passing through the artery wall was quantified using a scintillator β-counter. The artery retained the PTX and decreased its release from the coating. The retention of PTX by the arterial wall was more efficient when incubated in blood plasma in comparison with PBS. The retention/accumulation of PTX by the arterial wall provides a prolonged drug release and allows for the reduction in the dose of the drugs in electrospun-produced stent coatings.

Hydrogen-Bonding Layer Protecting Polyelectrolyte Capsules and Its Mechanical Property Study with Atomic Force Microscope

2008 ◽  
Vol 8 (6) ◽  
pp. 2996-3002 ◽  
Author(s):  
Liqin Ge ◽  
Xing Wang ◽  
Long Ba ◽  
Zhongze Gu
Keyword(s):  
Hydrogen Bonding ◽  
Atomic Force Microscope ◽  
Elastic Deformation ◽  
Self Assembly ◽  
Laser Scanning ◽  
Confocal Laser ◽  
Bonding Layer ◽  
Layer By Layer ◽  
Assembly Method ◽  
Atomic Force

The hydrogen-bonding multilayered polyelectrolyte capsules with sizes around 6 μm were fabricated by layer-by-layer self-assembly method. The morphology of the obtained capsules was observed with Scanning Electron Microscope (SEM), Confocal Laser Scanning Microscope (CLSM) and Atomic Force Microscope (AFM), respectively. The elastic properties of the capsules were studied with AFM. The capsule was pressed by cantilever with different lengths, a glass bead glued at the end of the cantilever. The force curves were measured on the capsule in air. The Young's modulus of the capsule was obtained (E = 170 MPa for the loading). Results show that this model can predict the elastic deformation of the microcapsule. The accuracy of the elastic deformation of polymer capsule can be ensured using a cantilever of mediate stiffness. Our results show that the existence of the hydrogen-bonding layer makes the multilayered polyelectrolyte harder in comparison with the pure multilayered polyelectrolyte capsules.

Fabrication of montmorillonite and titanate nanotube based coatings via layer-by-layer self-assembly method to enhance the thermal stability, flame retardancy and ultraviolet protection of polyethylene terephthalate (PET) fabric

RSC Advances ◽  
2016 ◽  
Vol 6 (59) ◽  
pp. 53625-53634 ◽  
Author(s):  
Ying Pan ◽  
Wei Wang ◽  
Haifeng Pan ◽  
Jing Zhan ◽  
Yuan Hu
Keyword(s):  
Thermal Stability ◽  
Polyethylene Terephthalate ◽  
Flame Retardancy ◽  
Self Assembly ◽  
Layer By Layer ◽  
Pet Fabric ◽  
Thermal Oxidative Stability ◽  
Titanate Nanotube ◽  
Assembly Method ◽  
Ultraviolet Protection

Montmorillonite and titanate nanotube based coatings have been prepared through LbL self-assembly method, in order to enhance the thermal and thermal-oxidative stability, flame retardancy and UV protection of polyethylene terephthalate fabric.

Layer-by-layer self-assembly of multilayer films based on humic acid

2011 ◽  
Vol 519 (13) ◽  
pp. 4324-4328 ◽  
Author(s):  
Zhengxia Xu ◽  
Chenyang Hu ◽  
Hu Guoxin
Keyword(s):  
Humic Acid ◽  
Self Assembly ◽  
Multilayer Films ◽  
Layer By Layer

scholarly journals Carbon Nano-Onions Reinforced Multilayered Thin Film System for Stimuli-Responsive Drug Release

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1208
Author(s):  
Narsimha Mamidi ◽  
Ramiro Velasco Delgadillo ◽  
Aldo Gonzáles Ortiz ◽  
Enrique Barrera
Keyword(s):  
Thin Film ◽  
Thin Films ◽  
Drug Release ◽  
Self Assembly ◽  
Critical Role ◽  
Layer By Layer ◽  
Film System ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Thin Film System

Herein, poly (N-(4-aminophenyl) methacrylamide))-carbon nano-onions (PAPMA-CNOs = f-CNOs) and anilinated-poly (ether ether ketone) (AN-PEEK) have synthesized, and AN-PEEK/f-CNOs composite thin films were primed via layer-by-layer (LbL) self-assembly for stimuli-responsive drug release. The obtained thin films exhibited pH-responsive drug release in a controlled manner; pH 4.5 = 99.2% and pH 6.5 = 59.3% of doxorubicin (DOX) release was observed over 15 days. Supramolecular π-π stacking interactions between f-CNOs and DOX played a critical role in controlling drug release from thin films. Cell viability was studied with human osteoblast cells and augmented viability was perceived. Moreover, the thin films presented 891.4 ± 8.2 MPa of the tensile strength (σult), 43.2 ± 1.1 GPa of Young’s modulus (E), and 164.5 ± 1.7 Jg−1 of toughness (K). Quantitative scrutiny revealed that the well-ordered aligned nanofibers provide critical interphase, and this could be responsible for augmented tensile properties. Nonetheless, a pH-responsive and mechanically robust biocompatible thin-film system may show potential applications in the biomedical field.

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