Naked-eye colorimetric detection of HCV RNA mediated by a 5′ UTR-targeted antisense oligonucleotide and plasmonic gold nanoparticles

The Analyst ◽  
2021 ◽  
Author(s):  
Almas Shamaila Mohammed ◽  
Aniket Balapure ◽  
Mahammad Nanne Khaja ◽  
Ramakrishnan Ganesan ◽  
Jayati Ray Dutta
Keyword(s):  
Gold Nanoparticles ◽  
Antisense Oligonucleotide ◽  
Early Stage ◽  
Colorimetric Detection ◽  
Sensitive Detection ◽  
Clinical Samples ◽  
Hcv Rna ◽  
Naked Eye

An Au NP based facile strategy for the rapid, early-stage, and sensitive detection of HCV RNA in clinical samples which avoids thiol tagging to the antisense oligonucleotide and expensive infrastructure is presented.

Highly sensitive ‘naked-eye’ colorimetric detection of thiourea using gold nanoparticles

2015 ◽  
Vol 7 (12) ◽  
pp. 4927-4933 ◽  
Author(s):  
Yi-Liang Cao ◽  
Yan Li ◽  
Fei Zhang ◽  
Jian-Zhong Huo ◽  
Xiao-Jun Zhao
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanoparticle ◽  
Colorimetric Detection ◽  
Sensitive Detection ◽  
Naked Eye ◽  
Colorimetric System ◽  
Highly Sensitive ◽  
Aqueous Environments

A non aggregation colorimetric system was developed for the fast and sensitive detection of thiourea in aqueous environments using an unlabeled gold nanoparticle probe.

Zwitterionic peptide-capped gold nanoparticles for colorimetric detection of Ni2+

Nanoscale ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 5466-5473 ◽  
Author(s):  
Attasith Parnsubsakul ◽  
Sukunya Oaew ◽  
Werasak Surareungchai
Keyword(s):  
Gold Nanoparticles ◽  
Colorimetric Detection ◽  
Sensitive Detection ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

Recyclable zwitterionic peptide-capped AuNPs for highly sensitive detection of Ni2+.

scholarly journals Colorimetric Technique for Antimony Detection Based on the Use of Gold Nanoparticles Conjugated with Poly-A Oligonucleotide

2019 ◽  
Vol 9 (22) ◽  
pp. 4782
Author(s):  
Berlina ◽  
Komova ◽  
Zherdev ◽  
Gaur ◽  
Dzantiev
Keyword(s):  
Gold Nanoparticles ◽  
Drinking Water ◽  
Detection Limit ◽  
Gold Nanoparticle ◽  
Variation Coefficient ◽  
Sensitive Detection ◽  
Naked Eye ◽  
Nanoparticle Surface ◽  
Colorimetric Measurements ◽  
Target Analyte

A simple and rapid positive–negative colorimetric approach to determine the presence of antimony ions based on the use of gold nanoparticles conjugated with oligonucleotide (poly-A sequence) is developed. Colorimetric measurements reveal that the aggregates of modified gold nanoparticles were afforded after adding antimony ions, thus changing the solution color from pink to blue. The results of aptamer’s interaction on the gold nanoparticle surface with the target analyte can be detected either by photometry or by the naked eye. The realized assay provides rapid (2 min), sensitive (detection limit 10 ng/mL), specific, and precise (variation coefficient less than 3.8%) detection of antimony (III) in drinking water.

Colorimetric Detection of Melamine Based on Poly-Thymine Stabilized Gold Nanoparticles

2013 ◽  
Vol 790 ◽  
pp. 619-622
Author(s):  
Chong Jin ◽  
Hui Min Zhao ◽  
Meng Liu ◽  
Jun Ping Tian ◽  
Xie Quan
Keyword(s):  
Gold Nanoparticles ◽  
Color Change ◽  
Limit Of Detection ◽  
Pure Water ◽  
Colorimetric Detection ◽  
Colorimetric Method ◽  
Milk Powder ◽  
Aggregation Process ◽  
Naked Eye ◽  
Fresh Milk

A simple, fast and reliable colorimetric method for melamine detection based on gold nanoparticles (AuNPs) and poly-thymine (poly-T) is reported. Poly-T strands attract AuNPs through static electricity and keep them stable against aggregation in the presence of NaCl. The affinity between melamine and poly-T, hydrogen bond, frees AuNP from the protection provided by poly-T and thus makes AuNPs aggregate in the presence of NaCl. The color change of AuNPs from wine red to blue can be observed immediately by the naked eye during the aggregation process, and can be accurately recorded with the help of a UV/vis spetrophotometer within 5 minutes. The limit of detection (LOD) of melamine in pure water is 0.146 μmol/L with a linear range from 0.2×10-7 mol/L to 10.0×10-7 mol/L. In fresh milk and milk powder, the LOD is respectively as low as 2.37 μmol/L and 5.36 μmol/L.

Sensitive colorimetric detection of melamine with 1,4-dithiothreitol modified gold nanoparticles

2015 ◽  
Vol 7 (3) ◽  
pp. 924-929 ◽  
Author(s):  
Can Xiao ◽  
Xiaofang Zhang ◽  
Junfeng Liu ◽  
Ankang Yang ◽  
Hong Zhao ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Colorimetric Detection ◽  
The State ◽  
Naked Eye

The presence of melamine induces a change in the state of 1,4-dithiothreitol modified gold nanoparticles, and the concentration of melamine could be quantified by the naked eye or using a UV-vis spectrometer.

Rapid colorimetric detection of melamine by H2O2–Au nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (42) ◽  
pp. 32897-32901 ◽  
Author(s):  
Miaolin Yin ◽  
Lifang Zhao ◽  
Qin Wei ◽  
He Li
Keyword(s):  
Dairy Products ◽  
Au Nanoparticles ◽  
Detection Method ◽  
Colorimetric Detection ◽  
Sensitive Detection ◽  
Naked Eye

A simple, rapid and sensitive detection method by the naked eye for melamine in dairy products is reported.

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