Synthesis and Antibacterial Activity of Polymer-Antibiotic Conjugates Incorporated into a Resin-Based Dental Adhesive

2021 ◽  
Author(s):  
Ziwen Zhang ◽  
Megan M Jones ◽  
Camila Sabatini ◽  
Stephen T Vanyo ◽  
Ming Yang ◽  
...  

This work reports on polymer-antibiotic conjugates (PACs) as additives to resin-based restorative dental materials as a new strategy to convey sustained antibacterial character to these materials. Such antibacterial performance is...

Author(s):  
Débora Michelle Gonçalves de Amorim ◽  
Aretha Heitor Veríssimo ◽  
Anne Kaline Claudino Ribeiro ◽  
Rodrigo Othávio de Assunção e Souza ◽  
Isauremi Vieira de Assunção ◽  
...  

AbstractTo investigate the impact of radiotherapy on surface properties of restorative dental materials. A conventional resin composite—CRC (Aura Enamel), a bulk-fill resin composite—BFRC (Aura Bulk-fill), a conventional glass ionomer cement—CGIC (Riva self cure), and a resin-modified glass ionomer cement—RMGIC (Riva light cure) were tested. Forty disc-shaped samples from each material (8 mm diameter × 2 mm thickness) (n = 10) were produced according to manufacturer directions and then stored in water distilled for 24 h. Surface wettability (water contact angle), Vickers microhardness, and micromorphology through scanning electron microscopy (SEM) before and after exposition to ionizing radiation (60 Gy) were obtained. The data were statistically evaluated using the two-way ANOVA and Tukey posthoc test (p < 0.05). Baseline and post-radiation values of contact angles were statistically similar for CRC, BFRC, and RMGIC, whilst post-radiation values of contact angles were statistically lower than baseline ones for CGIC. Exposition to ionizing radiation statistically increased the microhardness of CRC, and statistically decreased the microhardness of CGIC. The surface micromorphology of all materials was changed post-radiation. Exposure to ionizing radiation negatively affected the conventional glass ionomer tested, while did not alter or improved surface properties testing of the resin composites and the resin-modified glass ionomer cement tested.


Polymers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 360
Author(s):  
Xiaojian Zhang ◽  
Kaili Dai ◽  
Chenyu Liu ◽  
Haofeng Hu ◽  
Fulin Luo ◽  
...  

Biomimetic microspheres containing alginate/carboxymethylcellulose/gelatin and coated with 0%, 1%, 3%, and 6% berberine (BACG, BACG-1B, BACG-3B, BACG-6B) were prepared by the oil-in-water emulsion method combined with spray drying. Through a series of physicochemical parameters and determination of hemostatic properties in vitro and in vivo, the results indicated that BACG and BACG-Bs were effective in inducing platelet adhesion/aggregation and promoting the hemostatic potential due to their biomimetic structure and rough surface. In addition, BACG-6B with high berberine proportion presented better hemostatic performance compared with the commercial hemostatic agent compound microporous polysaccharide hemostatic powder (CMPHP). BACG-6B also showed strong antibacterial activity in the in vitro test. The hemolysis test and cytotoxicity evaluation further revealed that the novel composite biomaterials have good hemocompatibility and biocompatibility. Thus, BACG-6B provides a new strategy for developing a due-functional (hemostat/antibacterial) biomedical material, which may have broad and promising applications in the future.


2001 ◽  
Author(s):  
Fatima A. A. Zanin ◽  
Dilma H. Souza-Campos ◽  
Sissi Zanin ◽  
Aldo Brugnera, Jr. ◽  
Jesus D. Pecora ◽  
...  

2016 ◽  
Vol 5 (2) ◽  
pp. 8
Author(s):  
Putri Ajri Mawadara ◽  
Martha Mozartha ◽  
Trisnawaty K

Hydroxyapatite (HA) is a bioceramic with excellentbiocompatible properties, and composition and crystal structure similar to apatite in the human dental structure and skeletal system. A number of researchers have attempted to evaluate the effect of the addition of HA powders to increasemechanical properties of restorative dental materials. In this study, HA was synthesized using chicken eggshell as calcium source for synthesizing HA by using precipitation technique. The aim of this study was to determine the effect of incorporation of eggshell-derived HA on the surface  hardness GIC (Fuji IX GP). Specimens were divided into two groups: group GIC without incorporation of HA as control group (n = 16) and group GIC with incorporation of 5% HA as experimental group (n = 16). Total of specimens were 32 cylinders 5mm diameter and 2mm height. Surface hardness GIC was measured with vickers microhardness tester. Data wasanalyzed by unpaired T-test. The mean of surface hardness for GIC control group was 51.37 ± 1,63VHN and the experimental group was 56.60 ± 1,22HVN. The results T-test showed a significant difference between groups (p<0.05). It can be concluded thatincorporation of eggshell-derivedHA could increasesurface hardness of GIC.


Dental Update ◽  
2002 ◽  
Vol 29 (4) ◽  
pp. 188-194 ◽  
Author(s):  
F.J.T. Burke ◽  
A.C.C. Shortall ◽  
E.C. Combe ◽  
T.C. Aitchison

2019 ◽  
Vol 38 (3) ◽  
pp. 378-387 ◽  
Author(s):  
Thapanee SRICHUMPONG ◽  
Pimnida PHOKHINCHATCHANAN ◽  
Noparat THONGPUN ◽  
Duangrudee CHAYSUWAN ◽  
Kallaya SUPUTTAMONGKOL

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