A PEGylated photosensitizer-core pH-responsive polymeric nanocarrier for imaging-guided combination chemotherapy and photodynamic therapy

2021 ◽  
Vol 45 (14) ◽  
pp. 6180-6185
Author(s):  
Zhijian Chang ◽  
Jia-Hai Ye ◽  
Fen Qi ◽  
Hongbao Fang ◽  
Fuyan Lin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Combination Chemotherapy ◽  
Release Rate ◽  
Self Assembly ◽  
Ph Value ◽  
Ph Responsive ◽  
Considerable Time ◽  
Decreasing Ph ◽  
Dose Dependent ◽  
Polymeric Nanocarrier

A novel chemo-photodynamic combined therapeutic self-assembly polymeric platform (MPEG-Hyd-Br2-BODIPY) was constructed which can encapsulate DOX and exhibited an accelerated release rate with decreasing pH value which results in considerable time/dose-dependent cytotoxicity.

pH triggered self-assembly structural transition of ionic liquids in aqueous solutions: smart use of pH-responsive additives

RSC Advances ◽  
2015 ◽  
Vol 5 (80) ◽  
pp. 65583-65590 ◽  
Author(s):  
Huiyong Wang ◽  
Bo Tan ◽  
Hucheng Zhang ◽  
Jianji Wang
Keyword(s):  
Ionic Liquid ◽  
Ionic Liquids ◽  
Aqueous Solutions ◽  
Self Assembly ◽  
Structural Transition ◽  
Ph Value ◽  
Ph Responsive ◽  
Single Chain ◽  
Solution Ph ◽  
Spherical Micelles

The pH responsive fluids consisting of single-chain ionic liquid surfactants [Cnmim]Br (n = 12, 14) and hydrotropes can reversibly transform from spherical micelles to vesicles then to spherical micelles again with the change of the solution pH value.

A dual pH-responsive supramolecular gelator with aggregation-induced emission properties

Soft Matter ◽  
2018 ◽  
Vol 14 (30) ◽  
pp. 6166-6170 ◽  
Author(s):  
Marlen Externbrink ◽  
Steffen Riebe ◽  
Carsten Schmuck ◽  
Jens Voskuhl
Keyword(s):  
Mechanical Stress ◽  
Self Assembly ◽  
Ph Value ◽  
The Self ◽  
Ph Responsive ◽  
Aggregation Induced Emission ◽  
Emission Properties ◽  
External Stimuli

A novel organogelator with aggregation-induced emission properties responds to several external stimuli such as pH value, temperature and mechanical stress by the self-assembly of guanidiniocarbonyl pyrrole carboxylate zwitterions.

Synthesis and Characterization of Alkyl-Substituted Polyaniline by Using Ammonium Persulfate as both Oxidant and Dopant

2015 ◽  
Vol 1096 ◽  
pp. 147-155
Author(s):  
Xin Li ◽  
Mei Xiang Wan ◽  
Cong Ju Li
Keyword(s):  
Self Assembly ◽  
Ph Value ◽  
Ammonium Persulfate ◽  
Polymerization Process ◽  
Synthesis And Characterization ◽  
Polymerization Time ◽  
Reaction Solution ◽  
Alkyl Substitution ◽  
Decreasing Ph

Poly (o-toluidine) (POT), poly (m-toluidine) (PMT) and poly (p-toluidine) (PPT) were chemically oxidized by ammonium persulfate (APS) as both oxidant and dopant through a very simple self-assembly process. The structure characterizations by elemental analysis, XPS and FTIR demonstrated that APS is served as both oxidant and dopant due to the proton acid produced during polymerization, which is proven by the decreasing pH value of the reaction solution along with the increase of polymerization time. Besides, the influences of the alkyl-substitution position on the molecular structure, polymerization process, morphology and electrical properties are also discussed.

Porphyrin-functionalized coordination star polymers and their potential applications in photodynamic therapy

2019 ◽  
Vol 10 (45) ◽  
pp. 6116-6121 ◽  
Author(s):  
Tan Ji ◽  
Lei Xia ◽  
Wei Zheng ◽  
Guang-Qiang Yin ◽  
Tao Yue ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Self Assembly ◽  
Star Polymers ◽  
New Family ◽  
Potential Applications

We present a new family of porphyrin-functionalized coordination star polymers prepared through combination of coordination-driven self-assembly and post-assembly polymerization. Their self-assembly behaviour in water and potential for photodynamic therapy were demonstrated.

Oxidation of hydrogen peroxide at the dropping mercury electrode

1984 ◽  
Vol 49 (10) ◽  
pp. 2320-2331 ◽  
Author(s):  
Miroslav Březina ◽  
Martin Wedell
Keyword(s):  
Hydrogen Peroxide ◽  
Superoxide Anion ◽  
Ph Value ◽  
Mercury Electrode ◽  
Electrode Process ◽  
Electrochemical Processes ◽  
Dropping Mercury Electrode ◽  
Oxidation Of Hydrogen ◽  
Decreasing Ph ◽  
Rate Controlling Step

Reduction of oxygen and oxidation of hydrogen peroxide at the dropping mercury electrode are electrochemical processes strongly influenced both by the pH value and the anions in solution. With decreasing pH, both processes become irreversible, especially in the presence of anions with a negative φ2 potential of the diffusion part of the double layer. In the case of irreversible oxygen reduction, the concept that the rate-controlling step of the electrode process is the acceptance of the first electron with the formation of the superoxide anion, O2-, was substantiated. Oxidation of hydrogen peroxide becomes irreversible at a lower pH value than the reduction of oxygen. The slowest, i.e. rate-controlling step of the electrode process in borate buffers at pH 9-10 is the transfer of the second electron, i.e. oxidation of superoxide to oxygen.

scholarly journals Microstructure and Properties of Self-Assembly Graphene Microcapsules: Effect of the pH Value

Nanomaterials ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 587 ◽  
Author(s):  
Yan-Dong Guo ◽  
Jun-Feng Su ◽  
Ru Mu ◽  
Xin-Yu Wang ◽  
Xiao-Long Zhang ◽  
...  
Keyword(s):  
Electron Microscope ◽  
Photoelectron Spectroscopy ◽  
Self Assembly ◽  
Chemical Engineering ◽  
Ph Value ◽  
Liquid Paraffin ◽  
Energy Dispersive Spectrometer ◽  
Core Material ◽  
Microstructure And Properties ◽  
Ph Values

Graphene has attracted attention in the material field of functional microcapsules because of its excellent characteristics. The content and state of graphene in shells are critical for the properties of microcapsules, which are greatly affected by the charge adsorption equilibrium. The aim of this work was to investigate the effect of pH value on the microstructure and properties of self-assembly graphene microcapsules in regard to chemical engineering. Microcapsule samples were prepared containing liquid paraffin by a self-assembly polymerization method with graphene/organic hybrid shells. The morphology, average size and shell thickness parameters were investigated for five microcapsule samples fabricated under pH values of 3, 4, 5, 6 and 7. The existence and state of graphene in dry microcapsule samples were analyzed by using methods of scanning electron microscope (SEM), transmission electron microscope (TEM) and X-ray photoelectron spectroscopy (XPS). Fourier Transform Infrared Spectoscopy (FT-IR) and Energy Dispersive Spectrometer (EDS) were applied to analyze the graphene content in shells. These results proved that graphene had existed in shells and the pH values greatly influenced the graphene deposition on shells. It was found that the microcapsule sample fabricated under pH = 5 experienced the largest graphene deposited on shells with the help of macromolecules entanglement and electrostatic adherence. This microcapsules sample had enhanced thermal stability and larger thermal conductivity because of additional graphene in shells. Nanoindentation tests showed this sample had the capability of deforming resistance under pressure coming from the composite structure of graphene/polymer structure. Moreover, more graphene decreased the penetrability of core material out of microcapsule shells.

Calcium phosphate-based organic–inorganic hybrid nanocarriers with pH-responsive on/off switch for photodynamic therapy

2016 ◽  
Vol 4 (5) ◽  
pp. 826-838 ◽  
Author(s):  
Takahiro Nomoto ◽  
Shigeto Fukushima ◽  
Michiaki Kumagai ◽  
Kozo Miyazaki ◽  
Aki Inoue ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Calcium Phosphate ◽  
Ph Responsive ◽  
Inorganic Hybrid ◽  
Normal Tissues

Organic–inorganic hybrid nanocarriers permit efficient photodynamic therapy with reduced damage to normal tissues.

A New Approach to Fluorescent Chemosensor of Cu2+ Ion

2014 ◽  
Vol 513-517 ◽  
pp. 65-69
Author(s):  
Xiao Jun Hu ◽  
Xin Yan Hu ◽  
Zhi Zhang
Keyword(s):  
Aqueous Solution ◽  
Electron Transfer ◽  
Self Assembly ◽  
Ph Value ◽  
Sodium Dodecyl ◽  
Fluorescence Emission ◽  
Fluorescent Chemosensor ◽  
Dynamic Quenching ◽  
Transfer Effects ◽  
New Approach

According to the principle of dynamic quenching a new ON-OFF fluorescent chemosensor for Cu2+ions was designed, this chemosensor was composed of p-tert-butylthiacalix [arene (TCA),sodium dodecyl sulfate (SDS) and perylene through the form of self-assembly in aqueous solution. Addition of Cu2+ions could result in a quenching of the fluorescence emission of perylene inside micelles, which due to intramicellar complex-fluorophore electron-transfer or energy-transfer effects induced by the complexation of TCA with the Cu2+ions.The experimental results indicated that: Under the condition of TCA/perylene was 800/1, SDS concentration was 150mmol/L and pH value above 9, according to the fluorescence quenching ,within a certain range of the concentration of Cu2+ion can be linearly determined.

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