A protein corona sensor array detects breast and prostate cancers

Nanoscale ◽  
2020 ◽  
Vol 12 (32) ◽  
pp. 16697-16704 ◽  
Author(s):  
Luca Digiacomo ◽  
Kourosh Jafari-Khouzani ◽  
Sara Palchetti ◽  
Daniela Pozzi ◽  
Anna Laura Capriotti ◽  
...  
Keyword(s):  
Human Plasma ◽  
Sensor Array ◽  
Protein Corona ◽  
Specific Protein ◽  
Prostate Cancers ◽  
Disease Specific

Following exposure to human plasma nanoparticles are coated with a “disease-specific” protein corona.

Disease-specific protein corona sensor arrays may have disease detection capacity

2019 ◽  
Vol 4 (5) ◽  
pp. 1063-1076 ◽  
Author(s):  
Giulio Caracciolo ◽  
Reihaneh Safavi-Sohi ◽  
Reza Malekzadeh ◽  
Hossein Poustchi ◽  
Mahdi Vasighi ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Sensor Array ◽  
Sensor Arrays ◽  
Protein Corona ◽  
Specific Protein ◽  
Disease Detection ◽  
P Protein ◽  
Array Technology ◽  
Disease Specific

Protein corona sensor array technology identifies diseases through specific proteomics pattern recognition.

scholarly journals Correction: Disease-specific protein corona sensor arrays may have disease detection capacity

2020 ◽  
Vol 5 (2) ◽  
pp. 372-372
Author(s):  
Giulio Caracciolo ◽  
Reihaneh Safavi-Sohi ◽  
Reza Malekzadeh ◽  
Hossein Poustchi ◽  
Mahdi Vasighi ◽  
...  
Keyword(s):  
Sensor Arrays ◽  
Protein Corona ◽  
Specific Protein ◽  
Disease Detection ◽  
Disease Specific

Correction for ‘Disease-specific protein corona sensor arrays may have disease detection capacity’ by Giulio Caracciolo et al., Nanoscale Horiz., 2019, 4, 1063–1076.

Potential clinical applications of the personalized, disease-specific protein corona on nanoparticles

2020 ◽  
Vol 501 ◽  
pp. 102-111 ◽  
Author(s):  
María García Vence ◽  
María del Pilar Chantada-Vázquez ◽  
Sergio Vázquez-Estévez ◽  
José Manuel Cameselle-Teijeiro ◽  
Susana B. Bravo ◽  
...  
Keyword(s):  
Protein Corona ◽  
Specific Protein ◽  
Clinical Applications ◽  
Disease Specific

Personalized disease-specific protein corona influences the therapeutic impact of graphene oxide

Nanoscale ◽  
2015 ◽  
Vol 7 (19) ◽  
pp. 8978-8994 ◽  
Author(s):  
Mohammad Javad Hajipour ◽  
Jamshid Raheb ◽  
Omid Akhavan ◽  
Sareh Arjmand ◽  
Omid Mashinchian ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Protein Corona ◽  
Specific Protein ◽  
Therapeutic Impact ◽  
Disease Specific

Disease specific protein corona

2015 ◽  
Author(s):  
M. Rahman ◽  
M. Mahmoudi
Keyword(s):  
Protein Corona ◽  
Specific Protein ◽  
Disease Specific

scholarly journals Clinically accurate diagnosis of Alzheimer’s disease via multiplexed sensing of core biomarkers in human plasma

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Kayoung Kim ◽  
Min-Ji Kim ◽  
Da Won Kim ◽  
Su Yeong Kim ◽  
Steve Park ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Human Plasma ◽  
Sensor Array ◽  
Neurodegenerative Disorder ◽  
Limit Of Detection ◽  
Average Accuracy ◽  
Severity Of The Disease ◽  
High Degree ◽  
T Tau

AbstractAlzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, affecting one in ten people aged over 65 years. Despite the severity of the disease, early diagnosis of AD is still challenging due to the low accuracy or high cost of neuropsychological tests and neuroimaging. Here we report clinically accurate and ultrasensitive detection of multiple AD core biomarkers (t-tau, p-tau181, Aβ42, and Aβ40) in human plasma using densely aligned carbon nanotubes (CNTs). The closely packed and unidirectionally aligned CNT sensor array exhibits high precision, sensitivity, and accuracy, evidenced by a low coefficient of variation (<6%), a femtomolar-level limit of detection, and a high degree of recovery (>93.0%). By measuring the levels of t-tau/Aβ42, p-tau181/Aβ42, and Aβ42/Aβ40 in clinical blood samples, the sensor array successfully discriminates the clinically diagnosed AD patients from healthy controls with an average sensitivity of 90.0%, a selectivity of 90.0%, and an average accuracy of 88.6%.

Protein corona formation and its influence on biomimetic magnetite nanoparticles

2020 ◽  
Vol 8 (22) ◽  
pp. 4870-4882 ◽  
Author(s):  
Ana Peigneux ◽  
Emanuel A. Glitscher ◽  
Rawan Charbaji ◽  
Christoph Weise ◽  
Stefanie Wedepohl ◽  
...  
Keyword(s):  
Human Plasma ◽  
Cellular Uptake ◽  
Magnetite Nanoparticles ◽  
Colloidal Stability ◽  
Protein Corona ◽  
Corona Formation

Colloidal stability and cellular uptake of MamC-biomimetic magnetite nanoparticles (BMNPs) incubated with human plasma (PC-BMNPs).

scholarly journals Plasma proteins facilitates placental transfer of polystyrene particles

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Michael M. Gruber ◽  
Birgit Hirschmugl ◽  
Natascha Berger ◽  
Magdalena Holter ◽  
Snježana Radulović ◽  
...  
Keyword(s):  
Human Plasma ◽  
Human Placenta ◽  
Plasma Proteins ◽  
Placental Transfer ◽  
Ex Vivo ◽  
Biological Fluids ◽  
Protein Corona ◽  
Human Albumin ◽  
Placental Perfusion ◽  
The Impact

Abstract Background Nanoparticles, which are exposed to biological fluids are rapidly interacting with proteins and other biomolecules forming a corona. In addition to dimension, charge and material the distinct protein corona influences the interplay of nanoparticles with tissue barriers. In this study we were focused on the impact of in situ formed human plasma protein corona on the transfer of 80 nm polystyrene nanoparticles (PS-particles) across the human placenta. To study materno-to fetal PS transfer we used the human ex vivo placental perfusion approach, which represents an intact and physiological tissue barrier. To analyze the protein corona of PS particles we performed shotgun proteomics of isolated nanoparticles before and after tissue exposure. Results Human plasma incubated with PS-particles of 80 nm and subsequent formed protein corona enhanced the transfer across the human placenta compared to PS-corona formed by bovine serum albumin and dextran which served as a control. Quantitative and qualitative changes of plasma proteins determined the changes in PS transfer across the barrier. Based on the analysis of the PS-proteome two candidate proteins, namely human albumin and immunoglobulin G were tested if these proteins may account for the enhanced PS-transfer across the placenta. Interestingly, the protein corona formed by human albumin significantly induced the transfer of PS-particles across the tissue compared to the formed IgG-corona. Conclusion In total we demonstrate the PS corona dynamically and significantly evolves upon crossing the human placenta. Thus, the initial composition of PS particles in the maternal circulation is not predictive for their transfer characteristics and performance once beyond the barrier of the placenta. The precise mechanism of these effects remains to be elucidated but highlights the importance of using well designed biological models when testing nanoparticles for biomedical applications.

scholarly journals Interaction between Rice stripe virus Disease-Specific Protein and Host PsbP Enhances Virus Symptoms

2014 ◽  
Vol 7 (4) ◽  
pp. 691-708 ◽  
Author(s):  
Lingfang Kong ◽  
Jianxiang Wu ◽  
Lina Lu ◽  
Yi Xu ◽  
Xueping Zhou
Keyword(s):  
Virus Disease ◽  
Rice Stripe Virus ◽  
Specific Protein ◽  
Disease Specific
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