Cascade targeting tumor mitochondria with CuS nanoparticles for enhanced photothermal therapy in the second near-infrared window

2021 ◽  
Author(s):  
Haiyan Wu ◽  
Pengpeng Jia ◽  
Yu Zou ◽  
Jiang Jiang
Keyword(s):  
Treatment Outcome ◽  
Heat Generation ◽  
Side Effect ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Local Heat ◽  
Potential Side Effect ◽  
Improve Treatment ◽  
Improve Treatment Outcome ◽  
Local Heat Generation

Photothermal therapy, assisted by local heat generation using photothermal nanoparticles (NPs), is an emerging strategy to treat tumors noninvasively. To improve treatment outcome and to alleviate potential side effect on...

scholarly journals Polypeptide-Based Gold Nanoshells for Photothermal Therapy

2016 ◽  
Vol 22 (1) ◽  
pp. 18-25 ◽  
Author(s):  
Kristine M. Mayle ◽  
Kathryn R. Dern ◽  
Vincent K. Wong ◽  
Shijun Sung ◽  
Ke Ding ◽  
...  
Keyword(s):  
Heat Generation ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Gold Nanoshells ◽  
Core Material ◽  
Infrared Light ◽  
Great Promise ◽  
Laser Exposure ◽  
Enhanced Absorption ◽  
Block Copolypeptide

Targeted killing of cancer cells by engineered nanoparticles holds great promise for noninvasive photothermal therapy applications. We present the design and generation of a novel class of gold nanoshells with cores composed of self-assembled block copolypeptide vesicles with photothermal properties. Specifically, poly(L-lysine)60- block-poly(L-leucine)20 (K60L20) block copolypeptide vesicles coated with a thin layer of gold demonstrate enhanced absorption of light due to surface plasmon resonance (SPR) in the near-infrared range. We show that the polypeptide-based K60L20 gold nanoshells have low toxicity in the absence of laser exposure, significant heat generation upon exposure to near-infrared light, and, as a result, localized cytotoxicity within the region of laser irradiation in vitro. To gain a better understanding of our gold nanoshells in the context of photothermal therapy, we developed a comprehensive mathematical model for heat transfer and experimentally validated this model by predicting the temperature as a function of time and position in our experimental setup. This model can be used to predict which parameters of our gold nanoshells can be manipulated to improve heat generation for tumor destruction. To our knowledge, our results represent the first ever use of block copolypeptide vesicles as the core material of gold nanoshells.

scholarly journals Addressing Weight Suppression to Improve Treatment Outcome for Bulimia Nervosa

2018 ◽  
Vol 25 (3) ◽  
pp. 391-401 ◽  
Author(s):  
Adrienne Juarascio ◽  
Elin L. Lantz ◽  
Alexandra F. Muratore ◽  
Michael R. Lowe
Keyword(s):  
Treatment Outcome ◽  
Bulimia Nervosa ◽  
Improve Treatment ◽  
Improve Treatment Outcome ◽  
Weight Suppression

Family Psychoeducation Approaches for Borderline Personality Disorder

2017 ◽  
Author(s):  
Valerie Porr
Keyword(s):  
Social Support ◽  
Treatment Outcome ◽  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Family Members ◽  
Borderline Personality ◽  
Family Psychoeducation ◽  
Improve Treatment ◽  
Improve Treatment Outcome ◽  
The Family

This chapter provides a rationale for training family members of individuals with borderline personality disorder (BPD) to help them develop into therapeutic allies and treatment adjuncts. It also describes the experiences of family members in finding help for their loved ones with BPD and the family psychoeducation programs currently available for BPD and other disorders. By default, families often are the only alternative available to handle crisis situations since some individuals with BPD refuse to participate in therapy, have dropped out of therapy, or appropriate BPD services are not available in their communities. With an understanding of BPD, social support, and appropriate training, families can potentially develop as adjuncts and that can help improve treatment outcome

304: Interstitial Cystitis: Potassium Sensitivity Test (PST) can Improve Treatment Outcome

2005 ◽  
Vol 173 (4S) ◽  
pp. 84-84
Author(s):  
Suresh K. Gupta ◽  
Lol Pidcock ◽  
Manal Kumar ◽  
Nigel J. Parr
Keyword(s):  
Treatment Outcome ◽  
Interstitial Cystitis ◽  
Sensitivity Test ◽  
Improve Treatment ◽  
Improve Treatment Outcome
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