scholarly journals Layered terbium hydroxides for simultaneous drug delivery and imaging

2021 ◽  
Author(s):  
Margarita Strimaite ◽  
Clarissa Harman ◽  
Huan Duan ◽  
Yuwei Wang ◽  
Gemma-Louise Davies ◽  
...  

Layered rare-earth hydroxides have begun to gather increasing attention as potential theranostic platforms owing to their extensive intercalation chemistry combined with magnetic and fluorescent properties. In this work, the potential...

2011 ◽  
Vol 322 ◽  
pp. 337-340
Author(s):  
Lian Cai Du

A tripodal ligand, 2-acetylpyridine-tris(2-aminoethyl)amine (L), pyridine-N-oxide and their ternary complexes with rare earth nitrates have been synthesized. These new complexes with the general formula of Ln·L·PyNO·(NO3)3·nH2O (where Ln = La, Nd, Tb, Pr, Eu, n = 1~3 ) were characterized by elemental analysis, IR spectra, thermal analysis and molar conductivity. All the complexes are stable in air. The results show that the lanthanide ions in each complex are coordinated by nitrogen atoms of the ligand, oxygen atoms of PyNO and the nitrates. The fluorescent properties of the Eu(III) and Tb(III) complexes in solid were investigated.


RSC Advances ◽  
2015 ◽  
Vol 5 (43) ◽  
pp. 33999-34007 ◽  
Author(s):  
Zhiyang Zhang ◽  
Xiaoyan Ma ◽  
Zhirong Geng ◽  
Kuaibing Wang ◽  
Zhilin Wang

CDDP was loaded onto the surface of carboxyl polymer-coated NaYF4:Yb3+/Tm3+ nanoparticles prepared by hydrothermal treatment in the form of Pt–O bonds, and delivered through cellular uptake of the NaYF4–CDDP composite.


2020 ◽  
Vol 56 (62) ◽  
pp. 8766-8769 ◽  
Author(s):  
Man-Man Xu ◽  
Tong-Tong Jia ◽  
Bingjie Li ◽  
Wang Ma ◽  
Xiaoyuan Chen ◽  
...  

The fluorescent properties of atomically precise nanoclusters have been regulated by solvent-induced atomic structure transformation and cationic polymer-induced self-assembly for cell imaging and drug delivery.


2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Ching-Ping Liu ◽  
Shih-Hsun Cheng ◽  
Nai-Tzu Chen ◽  
Leu-Wei Lo

Elaborate design of energy transfer systems in luminescent nanocrystals revealed tremendous advantages in nanotechnology, especially in biosensing and drug delivery systems. Recently, upconversion nanoparticles have been discussed as promising probes as labels in biological assays and imaging. This article reviews the works performed in the recent years using quantum dot- and rare-earth doped nanoparticle-based energy transfer systems for biomedical applications.


MRS Advances ◽  
2018 ◽  
Vol 3 (1-2) ◽  
pp. 121-126
Author(s):  
Patsy Y. Arquieta Guillén ◽  
Alena Borisovna Kharissova ◽  
Beatriz Ortega García ◽  
Oxana V. Kharissova

ABSTRACTNowadays, carbon nanotubes have a lot of applications in daily life, being applied in the fabrication of cellphones, computers, nanotransistors, among many others. Currently, their new applications in biotechnology area are in research, in particular in order to find new biosensors with fluorescent properties applying on the basis of multi-wall carbon nanotubes (MWCNTs). In this work, the obtaining of carbon nanoparticles having fluorescent properties via spray pyrolysis is presented. Synthesis, properties, structural peculiarities, and applications of nanobuds and related nanostructures are discussed. MWCNTs, decorated with strontium aluminate SrAl12O19 and doped with rare-earth elements, were synthetized from distinct organic precursors and the corresponding metal oxides. The metal oxides used were Samarium (Sm), Europium (Eu), Neodymium (Nd), Lanthanum (La), Cerium (Ce) and some their combinations.The synthesis was carried out on the surface of optical fibres to obtain a uniform growth of forest-like MWCNTs, adding to metal oxide nanoparticles to their surface. The preparation of composites was carried out by spray pyrolysis techniques in dry nitrogen atmosphere in the temperature range from 780 to 850°C. The formed products were characterized by Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), FTIR spectroscopy, Raman spectroscopy and UV/visible spectroscopies. The analysis of the obtained data shows that the deposited nanoparticles are in the range of size 20-60 nm being uniformly distributed on the surface of MWCNTs. The samples, obtained at different temperatures and with doping metal oxides added to SrAl12O19, show different fluorescence behavior. The best results were observed with lanthanum oxide as a dopant. Possible applications as persistently luminescent phosphors for the formed MWCNTs-supported luminescent materials are proposed.


Nano LIFE ◽  
2014 ◽  
Vol 04 (03) ◽  
pp. 1441003 ◽  
Author(s):  
Timur Sh. Atabaev ◽  
Gulnoza Urmanova ◽  
Nguyen Hoa Hong

There is an increasing interest in the use of silica nanoparticles (NPs) for bioapplications. Highly mesoporous fluorescein dye-doped silica NPs that can carry a drug payload have been successfully synthesized through a facile microemulsion process. The morphology of the as-prepared silica NPs were characterized by scanning electron microscope and transmission electron microscope, whereas their optical properties were studied by photoluminescence spectroscopy. The results revealed that these silica NPs exhibit excellent properties, including large pore volume, a narrow size distribution and strong fluorescent properties. The synthesized silica NPs showed a good biocompatibility and a low cytotoxicity when incubated in a murine fibroblast L-929 cell line. The obtained silica NPs were further used as drug delivery carriers to investigate the in vitro drug release properties using doxorubicin (DOX) as a representative drug model. It was shown that synthesized silica NPs well sustained drug release properties, suggesting their potential applications for drug delivery.


2013 ◽  
Vol 19 (5) ◽  
pp. 1216-1221 ◽  
Author(s):  
Ana S. Rodrigues ◽  
Tânia Ribeiro ◽  
Fábio Fernandes ◽  
José Paulo S. Farinha ◽  
Carlos Baleizão

AbstractIn this paper we describe the preparation of fluorescent mesoporous silica nanoparticles (MSNs) for traceable drug delivery systems. The nanoparticles were prepared following a sol–gel procedure, incorporating a modified perylenediimide dye in the silica structure. Transmission electron microscopy and scanning electron microscopy show that the nanoparticles are monodispersed, with a spheroid shape and a raspberry-type surface morphology. The hybrid MSNs are robust, maintaining the mesoporous structure after template removal, with a pore diameter above 2 nm. A polymer shell was synthesized from the external surface of the hybrid nanoparticles by atom transfer radical polymerization, showing temperature-switchable collapsed/expanded conformation control. The fluorescent properties of the perylenediimide dye incorporated in the MSN pore walls are intact, and internalization in HEK293 cells shows that the nanoparticles are efficiently dispersed in the cytosol. These results show that the mesoporous fluorescent hybrid nanoparticles are an excellent platform for development of a traceable drug delivery system.


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