Antihypertensive activity of ACE-Renin inhibitory peptide derived from Moringa oleifera protein

2021 ◽  
Author(s):  
Keer Ma ◽  
Yujiao Wang ◽  
Mingjie Wang ◽  
Zhigao Wang ◽  
Xue-Feng Wang ◽  
...  
Keyword(s):  
Moringa Oleifera ◽  
Plant Protein ◽  
Antihypertensive Activity ◽  
Hypotensive Activity ◽  
Inhibitory Peptide ◽  
Medicinal Value

Moringa oleifera (MO) leaf is a potential plant protein resource with high nutritional and medicinal value. The study aims to investigate the hypotensive activity and stability of MO leaf peptide....

scholarly journals Moringa oleifera Lam and its Therapeutic Effects in Immune Disorders

2020 ◽  
Vol 11 ◽  
Author(s):  
Xiao Xiao ◽  
Jue Wang ◽  
Chen Meng ◽  
Weibo Liang ◽  
Tao Wang ◽  
...  
Keyword(s):  
Side Effects ◽  
Moringa Oleifera ◽  
Metabolic Diseases ◽  
Critical Role ◽  
Food Additives ◽  
Therapeutic Effects ◽  
Immune Disorders ◽  
Medicinal Value ◽  
Effect Of Food ◽  
Physical And Chemical

Moringa oleifera Lam., a plant native to tropical forests of India, is characterized by its versatile application as a food additive and supplement therapy. Accumulating evidence shows that Moringa plays a critical role in immune-related diseases. In this review, we cover the history, constituents, edibility, and general medicinal value of Moringa. The effects of Moringa in treating immune disorders are discussed in detail. Moringa can not only eliminate pathogens, including bacteria, fungi, viruses, and parasites, but also inhibit chronic inflammation, such as asthma, ulcerative colitis, and metabolic diseases. Additionally, Moringa can attenuate physical and chemical irritation-induced immune disorders, such as metal intoxication, drug side effects, or even the adverse effect of food additives. Autoimmune diseases, like rheumatoid arthritis, atopic dermatitis, and multiple sclerosis, can also be inhibited by Moringa. Collectively, Moringa, with its multiple immune regulatory bioactivities and few side effects, has a marked potential to treat immune disorders.

scholarly journals Moringa oleifera Lam.: A Biofunctional Edible Plant from India, Phytochemistry and Medicinal Properties

2019 ◽  
Vol 8 (1) ◽  
pp. 10 ◽  
Author(s):  
V. N. Pandey ◽  
Vandana Chauhan ◽  
V. S. Pandey ◽  
P. P. Upadhyaya ◽  
Olga R. Kopp
Keyword(s):  
Nutritional Value ◽  
Moringa Oleifera ◽  
Industrial Applications ◽  
Edible Plant ◽  
Medicinal Value ◽  
Form Part ◽  
Medicinal Properties ◽  
Common Illnesses ◽  
Almost All ◽  
Moringa Oleifera Lam

Moringa oleifera is a versatile horticulture tree with important medicinal, nutritional and industrial applications, widely distributed and used in India. The Moringa tree originated in India and was introduced to Africa from India and other countries as a health supplement. Almost all parts of the plant have shown nutritional value and are used in India for a variety of food preparations. In India, M. oleifera leaves are available in powder to treat mild malnourishment in children. About all parts like leaves, seeds and pods are used as vegetables. Phytochemicals such as flavonoids, tannins, triterpenoids, saponins, flavonoids, anthraquinones, alkaloids and others, are responsible for the medicinal value of this plant. This species is rich in protein, fatty acids, vitamins and minerals that form part of its quality as superfood. It has been reported to have strong antimicrobial, antioxidant, anti-inflammatory, hepatoprotective, diuretic, anthelminthic and antiurolithiatic properties, among others. People in India use this species to treat common illnesses because of its availability and easy preparation. This review provides information on the significant potential of Moringa and its nutritional, medicinal, pharmaceutical and industrial values.

Pharmacological aspects of Sigru (Moringa Oleifera Lam.) in view of Ayurveda

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Dr.Soumya MC ◽  
Dr. Sinimol TP ◽  
Dr. Varsha Sumedhan
Keyword(s):  
Moringa Oleifera ◽  
Pharmacological Properties ◽  
Ancient Text ◽  
Traditional Practice ◽  
Medicinal Value ◽  
Moringa Oleifera Lam

The medicinal value of a drug is usually determined based on its pharmacological properties. In traditional practice Sigru (Moringa oleifera Lam.) is used in the management of various diseases. It is necessary to have knowledge of the pharmacological attributes of a drug to use it correctly for the treatment. The pharmacological properties of Sigru has been explained in various ancient text books of Ayurveda. This review will keep an eye on the different properties of Sigru mentioned in various Ayurveda text books.

scholarly journals The transcriptome enables the identification of candidate genes behind medicinal value of Drumstick tree (Moringa oleifera)

Genomics ◽  
2020 ◽  
Vol 112 (1) ◽  
pp. 621-628 ◽  
Author(s):  
Shaik Naseer Pasha ◽  
K. Mohamed Shafi ◽  
Adwait G. Joshi ◽  
Iyer Meenakshi ◽  
K. Harini ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Moringa Oleifera ◽  
Medicinal Value ◽  
Drumstick Tree

Potential Angiotensin Converting Enzyme Inhibitors from Moringa oleifera

2019 ◽  
Vol 13 (3) ◽  
pp. 239-248 ◽  
Author(s):  
Huma Khan ◽  
Varun Jaiswal ◽  
Saurabh Kulshreshtha ◽  
Azhar Khan
Keyword(s):  
Binding Energy ◽  
Angiotensin Converting Enzyme ◽  
Active Sites ◽  
Moringa Oleifera ◽  
Bioactive Molecules ◽  
Ligand Docking ◽  
In Vivo Studies ◽  
Chronic Medical Condition ◽  
Antihypertensive Activity ◽  
Converting Enzyme

Background: Hypertension is the chronic medical condition and it affected billions of people worldwide. Natural medicines are the main alternatives to treatment for a majority of people suffering from hypertension. Niazicin-A, Niazimin-A, and Niaziminin-B compounds from Moringa oleifera ethanolic leave extract were reported to have potent antihypertensive activity. Objective: These compounds were targeted with Angiotensin-converting enzyme [ACE] which is one of the main regulatory enzymes of the renin-angiotensin system. Methods: Protein-ligand docking of these compounds with [ACE] [both domain N and C] was conceded out through Autodock vina and visualization was done by chimera. Pharmacokinetics study of these compounds was predicted by ADME-Toxicity Prediction. Results: Niazicin-A, Niazimin-A, and Niaziminin-B showed high binding affinity with ACE and partially blocked the active sites of the enzyme. Niazicin-A, Niazimin-A and Niaziminin-B showed the estimated free binding energy of -7.6kcal/mol kcal/mol, -8.8kcal/mol and -8.0kcal/mol respectively with C-domain of ACE and -7.9kcal/mol, -8.5kcal/mol and -7.7kcal/mol respectively with N-domain of ACE. The compounds showed better binding energy with angiotensinconverting enzyme in comparison to Captopril -5.5kcal/mol and -5.6kcal/mol and Enalapril [standard] -8.4kcal/mol and -7.5kcal/mol with C and N domain, respectively. Conclusion: Computationally, the selected bioactive molecules have shown better binding energy to known standard drugs which have been already known for inhibition of ACE and can further act as a pharmacophore for in vitro and in vivo studies in the development of alternative medicine.

scholarly journals Quantification of Multifunctional Dipeptide YA from Oyster Hydrolysate for Quality Control and Efficacy Evaluation

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Cheng-Liang Xie ◽  
Sang Soo Kang ◽  
Ciyong Lu ◽  
Yeung Joon Choi
Keyword(s):  
Quality Control ◽  
Functional Foods ◽  
Control Point ◽  
Raw 264.7 Cells ◽  
Antihypertensive Activity ◽  
Angiotensin I ◽  
Efficacy Evaluation ◽  
Inhibitory Peptide ◽  
Critical Control Point ◽  
Angiotensin I Converting Enzyme

YA is an angiotensin-I-converting enzyme- (ACE-) inhibitory peptide from oyster hydrolysate with antihypertensive activity. Its antioxidant and anti-inflammatory activity were investigated in this study. YA can dose-dependently quench DPPH and ABTS radical and inhibit lipopolysaccharide-induced nitric oxide in RAW 264.7 cells. YA is a multifunctional peptide and was selected as an indicator for quality control and efficacy evaluation of oyster hydrolysate. A practical HPLC/UV assay for YA quantification was developed and validated. It was proved to be accurate and reliable, according to parameters such as specificity, linearity, precision, and accuracy. The quantity results of YA showed that the stage of enzymatic hydrolysis was a critical control point for quality control; the efficacy of oyster hydrolysate can be enhanced after digested in the gastrointestinal tract due to the release of YA by brush border peptidases. Therefore, YA from oyster hydrolysate is a potential bioactive ingredient for functional foods to combat hypertension.

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