In the Danchi mineralization belt of Guangxi province, south China, the Dachang tin-polymetallic ore deposit is one of the largest Sn ore deposits in this world. But about the genesis and the ore source, there have been some disputes. In terms of the Dafulou deposit, the mineralization model and deposit mechanism is rather illegibility. By analysing and comparing the lead isotope of three ore deposit (the Changpo, the Lamo and the Dafulou), it show that the correlations of 206Pb/204Pb, 207Pb/204Pb and 208Pb/204Pb of sulfide minerals demonstrate obvious excellent linear relation. So, it is also suggested that the eastern mineralization belt, the middle mineralization belt and the western mineralization belt shared the same ore source. And, according to the features of no.22 ore body, the Dafulou deposit is characterized with the characteristics of the Sedimentary Exhalative Deposit (SEDEX).