A Biocatalytic Approach towards the Preparation of Natural Deoxyanthraquinones and their Impact on Cellular Viability

2022 ◽  
Author(s):  
Anshul Rajput ◽  
Arijit De ◽  
Amit Mondal ◽  
Kiran Das ◽  
Biswanath Maity ◽  
...  
Keyword(s):  
Cellular Viability ◽  
Stereoselective Reduction

Herein, a two-step chemoenzymatic process for the synthesis of medicinally important 3-deoxygenated anthra-9,10-quinones is developed. It involves a regio- and stereoselective reduction of hydroanthraquinones to (R)-configured dihydroanthracenones using an anthrol...

Demonstration of the cellular viability and safety of Enterococcus faecium CRL 183 in experiments of long term

2007 ◽  
Vol 87 (2) ◽  
pp. 181 ◽  
Author(s):  
Katia Sivieri ◽  
Veridiana P.S. Cano ◽  
Sandro R. Valentini ◽  
Elizeu A. Rossi
Keyword(s):  
Enterococcus Faecium ◽  
Cellular Viability

Artepillin C Induces Selective Oxidative Stress and Inhibits Migration and Invasion in a Comprehensive Panel of Human Cervical Cancer Cell Lines

2019 ◽  
Vol 18 (12) ◽  
pp. 1750-1760 ◽  
Author(s):  
Raquel P. Souza ◽  
Patrícia S. Bonfim-Mendonça ◽  
Gabrielle M.Z.F. Damke ◽  
Analine R.B. de-Assis Carvalho ◽  
Bianca A. Ratti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cervical Cancer ◽  
Cell Lines ◽  
Migration And Invasion ◽  
Epithelial Cell Line ◽  
Cellular Viability ◽  
Hpv 16 ◽  
Anticancer Properties ◽  
Artepillin C ◽  
Human Cervical Cancer

Background: Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis, and possesses, among other things, anticancer properties. However, to the best of our knowledge, there are no studies of artepillin C in cervical cancer. Method: To explore a new therapeutic candidate for cervical cancer, we have evaluated the effects of artepillin C on cellular viability in a comprehensive panel of human cervical cancer-derived cell lines including HeLa (human papillomavirus/HPV 18-positive), SiHa (HPV 16-positive), CaSki (HPV 16- and 18-positive) and C33A (HPV-negative) cells compared to a spontaneously immortalized human epithelial cell line (HaCaT). Results: Our results demonstrated that artepillin C had a selective effect on cellular viability and could induce apoptosis possibly by intrinsic pathway, likely a result of oxidative stress, in all cancer-derived cell lines but not in HaCaT. Additionally, artepillin C was able to inhibit the migration and invasion of cancer cells. Conclusion: Thus, artepillin C appears to be a promising new candidate as an anticancer drug for cervical cancer induced by different HPV types.

scholarly journals Chemo- and Stereoselective Reduction of Polyfunctional Carbonyl Compounds by Mucor rouxii

Molecules ◽  
2000 ◽  
Vol 5 (12) ◽  
pp. 370-371
Author(s):  
Constanza Mangone ◽  
Elba Pereyra ◽  
Silvia Moreno de Colonna ◽  
Alicia Baldessari
Keyword(s):  
Carbonyl Compounds ◽  
Mucor Rouxii ◽  
Stereoselective Reduction

BIO-CORROSION RESISTANCE AND BIOCOMPATIBILITY OF A ZrTi-BASED BMGMC AS POTENTIAL HARD TISSUE IMPLANTS

2013 ◽  
Vol 27 (19) ◽  
pp. 1341029
Author(s):  
XIAOBO HUANG ◽  
JIAOJUAN ZOU ◽  
CHAN WANG ◽  
RUIQIANG HANG ◽  
JUNWEI QIAO ◽  
...  
Keyword(s):  
Cell Culture ◽  
Corrosion Resistance ◽  
Reference Material ◽  
Corrosion Current ◽  
Electrochemical Measurements ◽  
Ti Alloy ◽  
Cellular Viability ◽  
Hard Tissue ◽  
Cellular Behaviors ◽  
Current Densities

In this study, we compared the bio-corrosion resistance and biocompatibility of a ZrTi -based BMGMC ( Zr 58.5 Ti 14.3 Ni 4.9 Cu 6.1 Nb 5.2 Be 11.0). The Ti - 6Al - 4V alloy was used as a reference material. By utilizing the electrochemical measurements and M3T3 cell culture, the corrosion resistance and biocompatibility of this BMGMC were evaluated. The BMGMC displayed high positive corrosion potentials and low corrosion current densities, which indicated that this material exhibited a highly improved corrosion resistance than the Ti alloy. The cells could adhere on the surface of this BMGMC and exhibited improved cellular behaviors, such as cellular viability and cytoskeketal structure. In summary, the ZrTi -based BMGMC showed great potential for applications in the hard tissue implants.

Sign in / Sign up

Export Citation Format

Share Document