Single Molecular Nanomedicine with NIR Light-Initiated Superoxide Radical, Singlet Oxygen and Thermal Generation for Hypoxia‐Overcoming Cancer Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jipsa Chelora ◽  
Yuchao Liang ◽  
Wei-Chih Wei ◽  
Xiao Cui ◽  
Yafang XIAO ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Short Wavelength ◽  
Superoxide Radical ◽  
Low Oxygen ◽  
Tissue Penetration ◽  
Thermal Generation ◽  
Nir Light ◽  
Recent Attention

While photodynamic therapy (PDT) of cancer has attracted much recent attention, its general applications are limited by shallow tissue penetration depth of short-wavelength photons and the low oxygen contents in...

Biodegradable Nano-photosensitizer with Photoactivatable Singlet Oxygen Generation for Synergistic Phototherapy

2021 ◽  
Author(s):  
Jiaxin Shen ◽  
Dandan Chen ◽  
Ye Liu ◽  
Guoyang Gao ◽  
Zhihe Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Promising Method ◽  
Normal Cells ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light

Photodynamic therapy (PDT) is a promising method for cancer therapy and also may initiate unexpected damages to normal cells and tissues. Herein, we developed a near-infrared (NIR) light-activatable nanophotosensitizer, which...

scholarly journals A self-illuminating nanoparticle for inflammation imaging and cancer therapy

2019 ◽  
Vol 5 (1) ◽  
pp. eaat2953 ◽  
Author(s):  
Xiaoqiu Xu ◽  
Huijie An ◽  
Dinglin Zhang ◽  
Hui Tao ◽  
Yin Dou ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Cancer Therapy ◽  
In Vivo Imaging ◽  
Resonance Energy ◽  
External Irradiation ◽  
Tissue Penetration ◽  
Photodynamic Therapy Of Cancer ◽  
Inflammation Imaging

Nanoparticles have been extensively used for inflammation imaging and photodynamic therapy of cancer. However, the major translational barriers to most nanoparticle-based imaging and therapy applications are the limited depth of tissue penetration, inevitable requirement of external irradiation, and poor biocompatibility of the nanoparticles. To overcome these critical limitations, we synthesized a sensitive, specific, biodegradable luminescent nanoparticle that is self-assembled from an amphiphilic polymeric conjugate with a luminescent donor (luminol) and a fluorescent acceptor [chlorin e6 (Ce6)] for in vivo luminescence imaging and photodynamic therapy in deep tissues. Mechanistically, reactive oxygen species (ROS) and myeloperoxidase generated in inflammatory sites or the tumor microenvironment trigger bioluminescence resonance energy transfer and the production of singlet oxygen (1O2) from the nanoparticle, enabling in vivo imaging and cancer therapy, respectively. This self-illuminating nanoparticle shows an excellent in vivo imaging capability with suitable tissue penetration and resolution in diverse animal models of inflammation. It is also proven to be a selective, potent, and safe antitumor nanomedicine that specifically kills cancer cells via in situ1O2produced in the tumor microenvironment, which contains a high level of ROS.

Design and Application of Inorganic Nanoparticles for Sonodynamic Cancer Therapy

2021 ◽  
Author(s):  
LIhong Sun ◽  
Ping Wang ◽  
Jinxia Zhang ◽  
Yang Sun ◽  
Suhui Sun ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Cancer Therapy ◽  
Patient Compliance ◽  
Inorganic Nanoparticles ◽  
Tissue Penetration ◽  
Sonodynamic Therapy ◽  
Significant Attention ◽  
Design And Application

As an alternative to photodynamic therapy (PDT), ultrasound-triggered tumor sonodynamic therapy (SDT) has garnered significant attention, owing to its high tissue penetration, few side effects, and reliable patient compliance. A...

scholarly journals 1- and 2-Photon Phototherapeutic Effects of Ru(II) Polypyridine Complexes in the Hypoxic Centre of Large Multicellular Tumour Spheroids and Tumour-Bearing Mice

2020 ◽  
Author(s):  
Johannes Karges ◽  
Shi Kuang ◽  
Yih Ching Ong ◽  
Hui Chao ◽  
Gilles Gasser
Keyword(s):  
Photodynamic Therapy ◽  
Metal Complexes ◽  
Singlet Oxygen ◽  
Lead Compound ◽  
Low Oxygen ◽  
Cellular Architecture ◽  
Clinical Challenge ◽  
Tumour Spheroids ◽  
Epithelial Tumour ◽  
Polypyridine Complexes

During the last decades, photodynamic therapy (PDT), an approved medical technique, has received increasing attention to treat certain types of cancer. Despite recent improvements, the treatment of large tumors remains a major clinical challenge due to the low ability of the photosensitizer (PS) to penetrate a 3D cellular architecture and the low oxygen concentrations present in the tumour centre. To mimic the conditions found in clinical tumors, exceptionally large 3D multicellular tumour spheroids (MCTSs) with a diameter of 800 µm were used in this work to test a series of new Ru(II) polypyridine complexes as 1-Photon and 2-Photon PSs. These metal complexes were found to fully penetrate the 3D cellular architecture and to generate singlet oxygen in the hypoxic centre upon light irradiation. While having no observed dark toxicity, the lead compound of this study showed an impressive phototoxicity upon clinically relevant 1-Photon (595 nm) or 2-Photon (800 nm) excitation with a full eradication of the hypoxic centre of the MCTSs. Importantly, this efficacy was also demonstrated on mice bearing an adenocarcinomic human alveolar basal epithelial tumour.

scholarly journals 1- and 2-Photon Phototherapeutic Effects of Ru(II) Polypyridine Complexes in the Hypoxic Centre of Large Multicellular Tumour Spheroids and Tumour-Bearing Mice

2020 ◽  
Author(s):  
Johannes Karges ◽  
Shi Kuang ◽  
Yih Ching Ong ◽  
Hui Chao ◽  
Gilles Gasser
Keyword(s):  
Photodynamic Therapy ◽  
Metal Complexes ◽  
Singlet Oxygen ◽  
Lead Compound ◽  
Low Oxygen ◽  
Cellular Architecture ◽  
Clinical Challenge ◽  
Tumour Spheroids ◽  
Epithelial Tumour ◽  
Polypyridine Complexes

During the last decades, photodynamic therapy (PDT), an approved medical technique, has received increasing attention to treat certain types of cancer. Despite recent improvements, the treatment of large tumors remains a major clinical challenge due to the low ability of the photosensitizer (PS) to penetrate a 3D cellular architecture and the low oxygen concentrations present in the tumour centre. To mimic the conditions found in clinical tumors, exceptionally large 3D multicellular tumour spheroids (MCTSs) with a diameter of 800 µm were used in this work to test a series of new Ru(II) polypyridine complexes as 1-Photon and 2-Photon PSs. These metal complexes were found to fully penetrate the 3D cellular architecture and to generate singlet oxygen in the hypoxic centre upon light irradiation. While having no observed dark toxicity, the lead compound of this study showed an impressive phototoxicity upon clinically relevant 1-Photon (595 nm) or 2-Photon (800 nm) excitation with a full eradication of the hypoxic centre of the MCTSs. Importantly, this efficacy was also demonstrated on mice bearing an adenocarcinomic human alveolar basal epithelial tumour.

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