scholarly journals 1- and 2-Photon Phototherapeutic Effects of Ru(II) Polypyridine Complexes in the Hypoxic Centre of Large Multicellular Tumour Spheroids and Tumour-Bearing Mice

2020 ◽  
Author(s):  
Johannes Karges ◽  
Shi Kuang ◽  
Yih Ching Ong ◽  
Hui Chao ◽  
Gilles Gasser
Keyword(s):  
Photodynamic Therapy ◽  
Metal Complexes ◽  
Singlet Oxygen ◽  
Lead Compound ◽  
Low Oxygen ◽  
Cellular Architecture ◽  
Clinical Challenge ◽  
Tumour Spheroids ◽  
Epithelial Tumour ◽  
Polypyridine Complexes

During the last decades, photodynamic therapy (PDT), an approved medical technique, has received increasing attention to treat certain types of cancer. Despite recent improvements, the treatment of large tumors remains a major clinical challenge due to the low ability of the photosensitizer (PS) to penetrate a 3D cellular architecture and the low oxygen concentrations present in the tumour centre. To mimic the conditions found in clinical tumors, exceptionally large 3D multicellular tumour spheroids (MCTSs) with a diameter of 800 µm were used in this work to test a series of new Ru(II) polypyridine complexes as 1-Photon and 2-Photon PSs. These metal complexes were found to fully penetrate the 3D cellular architecture and to generate singlet oxygen in the hypoxic centre upon light irradiation. While having no observed dark toxicity, the lead compound of this study showed an impressive phototoxicity upon clinically relevant 1-Photon (595 nm) or 2-Photon (800 nm) excitation with a full eradication of the hypoxic centre of the MCTSs. Importantly, this efficacy was also demonstrated on mice bearing an adenocarcinomic human alveolar basal epithelial tumour.

scholarly journals 1- and 2-Photon Phototherapeutic Effects of Ru(II) Polypyridine Complexes in the Hypoxic Centre of Large Multicellular Tumour Spheroids and Tumour-Bearing Mice

2020 ◽  
Author(s):  
Johannes Karges ◽  
Shi Kuang ◽  
Yih Ching Ong ◽  
Hui Chao ◽  
Gilles Gasser
Keyword(s):  
Photodynamic Therapy ◽  
Metal Complexes ◽  
Singlet Oxygen ◽  
Lead Compound ◽  
Low Oxygen ◽  
Cellular Architecture ◽  
Clinical Challenge ◽  
Tumour Spheroids ◽  
Epithelial Tumour ◽  
Polypyridine Complexes

During the last decades, photodynamic therapy (PDT), an approved medical technique, has received increasing attention to treat certain types of cancer. Despite recent improvements, the treatment of large tumors remains a major clinical challenge due to the low ability of the photosensitizer (PS) to penetrate a 3D cellular architecture and the low oxygen concentrations present in the tumour centre. To mimic the conditions found in clinical tumors, exceptionally large 3D multicellular tumour spheroids (MCTSs) with a diameter of 800 µm were used in this work to test a series of new Ru(II) polypyridine complexes as 1-Photon and 2-Photon PSs. These metal complexes were found to fully penetrate the 3D cellular architecture and to generate singlet oxygen in the hypoxic centre upon light irradiation. While having no observed dark toxicity, the lead compound of this study showed an impressive phototoxicity upon clinically relevant 1-Photon (595 nm) or 2-Photon (800 nm) excitation with a full eradication of the hypoxic centre of the MCTSs. Importantly, this efficacy was also demonstrated on mice bearing an adenocarcinomic human alveolar basal epithelial tumour.

Single Molecular Nanomedicine with NIR Light-Initiated Superoxide Radical, Singlet Oxygen and Thermal Generation for Hypoxia‐Overcoming Cancer Therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Jipsa Chelora ◽  
Yuchao Liang ◽  
Wei-Chih Wei ◽  
Xiao Cui ◽  
Yafang XIAO ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Short Wavelength ◽  
Superoxide Radical ◽  
Low Oxygen ◽  
Tissue Penetration ◽  
Thermal Generation ◽  
Nir Light ◽  
Recent Attention

While photodynamic therapy (PDT) of cancer has attracted much recent attention, its general applications are limited by shallow tissue penetration depth of short-wavelength photons and the low oxygen contents in...

Ruthenium Complexes for 1- and 2-Photon Photodynamic Therapy: From In Silico Prediction to In Vivo Applications

2020 ◽  
Author(s):  
Johannes Karges ◽  
Shi Kuang ◽  
Federica Maschietto ◽  
Olivier Blacque ◽  
Ilaria Ciofini ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
In Silico ◽  
Aqueous Solubility ◽  
The Body ◽  
Photon Absorption ◽  
Multicellular Tumor Spheroids ◽  
Spectral Window ◽  
Photon Excitation ◽  
Polypyridine Complexes

<div>The use of photodynamic therapy (PDT) against cancer has received increasing attention overthe recent years. However, the application of the currently approved photosensitizers (PSs) is somehow limited by their poor aqueous solubility, aggregation, photobleaching and slow clearance from the body. To overcome these limitations, there is a need for the development of new classes of PSs with ruthenium(II) polypyridine complexes currently gaining momentum. However, these compounds generally lack significant absorption in the biological spectral window, limiting their application to treat deep-seated or large tumors. To overcome this drawback, ruthenium(II) polypyridine complexes designed in silico with (E,E’)-4,4´-bisstyryl 2,2´-bipyridine ligands showed impressive 1- and 2-Photon absorption up to a magnitude higher than the ones published so far. While non-toxic in the dark, these compounds were found phototoxic in various 2D monolayer cells, 3D multicellular tumor spheroids and be able to eradicate a multiresistant tumor inside a mouse model upon clinically relevant 1-Photon and 2 Photon excitation.</div>

Optical Properties of Photodynamic Therapy Drugs in Different Environments: The Paradigmatic Case of Temoporfin

2020 ◽  
Author(s):  
busenur Aslanoglu ◽  
Ilya Yakavets ◽  
Vladimir Zorin ◽  
Henri-Pierre Lassalle ◽  
Francesca Ingrosso ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Minimally Invasive ◽  
Visible Light ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Molecular Oxygen ◽  
Computational Tools

Computational tools have been used to study the photophysical and photochemical features of photosensitizers in photodynamic therapy (PDT) –a minimally invasive, less aggressive alternative for cancer treatment. PDT is mainly based by the activation of molecular oxygen through the action of a photoexcited sensitizer (photosensitizer). Temoporfin, widely known as mTHPC, is a second-generation photosensitizer, which produces the cytotoxic singlet oxygen when irradiated with visible light and hence destroys tumor cells. However, the bioavailability of the mostly hydrophobic photosensitizer, and hence its incorporation into the cells, is fundamental to achieve the desired effect on malignant tissues by PDT. In this study, we focus on the optical properties of the temoporfin chromophore in different environments –in <i>vacuo</i>, in solution, encapsulated in drug delivery agents, namely cyclodextrin, and interacting with a lipid bilayer.

Design of Novel Photosensitizers and Controlled Singlet Oxygen Generation for Photodynamic Therapy

2021 ◽  
Author(s):  
Esra Tanrıverdi Eçik ◽  
Onur BULUT ◽  
Hasan Hüseyin Kazan ◽  
Elif Şenkuytu ◽  
Bunyemin Cosut
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Singlet Oxygen ◽  
Side Effect ◽  
Side Effect Profile ◽  
High Ability ◽  
Lower Side ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Promising Strategy

Photodynamic therapy (PDT) is a promising strategy in cancer treatment with its relatively lower side effect profile. Undoubtedly, the key component of PDT is the photosensitizers with a high ability...

scholarly journals BSA-encapsulated cyclometalated iridium complexes as nano-photosensitizers for photodynamic therapy of tumor cells

RSC Advances ◽  
2021 ◽  
Vol 11 (25) ◽  
pp. 15323-15331
Author(s):  
Yao Xu ◽  
Xiang Wang ◽  
Kang Song ◽  
Jun Du ◽  
Jinliang Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Tumor Cells ◽  
Iridium Complexes

Three new iridium complexes were synthesized and fabricated with BSA to form nano-photosensitizers, which can catalyze oxygen to produce singlet oxygen to achieve photodynamic therapy of tumor cells.

Linear and high-molecular-weight poly-porphyrins for efficient photodynamic therapy

2021 ◽  
Author(s):  
Nan Zheng ◽  
Xiahui Li ◽  
Shangwei Huangfu ◽  
Kangkai Xia ◽  
Ruofei Yue ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
High Molecular Weight ◽  
Linear Poly ◽  
High Molecular Weight Poly

A linear poly-porphyrin with high Mw and conjugated by PEG and acetazolamide was developed with enhanced singlet oxygen quantum yield, improved photo-toxicity and excellent in vivo photodynamic therapy.

scholarly journals Applications of Photodynamic Therapy in Management of Periodontal Disease - A Review

2018 ◽  
Vol 08 (04) ◽  
pp. 024-027
Author(s):  
Shiny Inasu ◽  
Biju Thomas
Keyword(s):  
Photodynamic Therapy ◽  
Periodontal Disease ◽  
Infection Control ◽  
Singlet Oxygen ◽  
Current Status ◽  
Target Cells ◽  
Oral Diseases ◽  
Dynamic Therapy ◽  
Reactive Agents ◽  
Photo Dynamic Therapy

AbstractA novel noninvasive photochemical approach for infection control, namely photodynamic therapy, has received much attention in the treatment of oral diseases which requires three nontoxic ingredients namely visible harmless light, a photosensitizer and oxygen are involved in this therapy. It is based on the principle that a photosensitizer binds to the target cells which when activated by light of a suitable wavelength results in the production of singlet oxygen and other very reactive agents that are extremely toxic to certain cells and bacteria. This article highlights the application of photo-dynamic therapy in management of periodontal disease and its current status.

Biodegradable Nano-photosensitizer with Photoactivatable Singlet Oxygen Generation for Synergistic Phototherapy

2021 ◽  
Author(s):  
Jiaxin Shen ◽  
Dandan Chen ◽  
Ye Liu ◽  
Guoyang Gao ◽  
Zhihe Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Promising Method ◽  
Normal Cells ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light

Photodynamic therapy (PDT) is a promising method for cancer therapy and also may initiate unexpected damages to normal cells and tissues. Herein, we developed a near-infrared (NIR) light-activatable nanophotosensitizer, which...

scholarly journals Design of BODIPY dyes as triplet photosensitizers: electronic properties tailored for solar energy conversion, photoredox catalysis and photodynamic therapy

2021 ◽  
Author(s):  
Elena Bassan ◽  
Andrea Gualandi ◽  
Pier Giorgio Cozzi ◽  
Paola Ceroni
Keyword(s):  
Heavy Metal ◽  
Photodynamic Therapy ◽  
Solar Energy ◽  
Metal Complexes ◽  
Energy Conversion ◽  
Electronic Properties ◽  
Solar Energy Conversion ◽  
Photoredox Catalysis

BODIPYs offer a versatile platform to build organic triplet photosensitisers for PDT, TTA upconversion and photocatalysis. Tuning their properties provides the opportunity of replacing heavy-metal complexes and can lead to improved sustainability.

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