Hydrogen peroxide-responsive AIE probe for imaging-guided organelle targeting and photodynamic cancer cell ablation

2021 ◽  
Author(s):  
Qian Wu ◽  
Youmei Li ◽  
Ying Li ◽  
Dong Wang ◽  
Ben Zhong Tang
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Cancer Cell ◽  
Reactive Oxygen ◽  
Living Cells ◽  
Oxygen Species ◽  
Cell Ablation ◽  
Selective Monitoring ◽  
Organelle Targeting

Hydrogen peroxide (H2O2), as one kind of key reactive oxygen species (ROS), is mainly produced endogenously primarily in the mitochondria. The selective monitoring of H2O2 in living cells is of...

scholarly journals Hydrogen Peroxide-Responsive AIE Probe for Imaging-Guided Organelle Targeting and Photodynamic Cancer Cell Ablation

2020 ◽  
Author(s):  
Qian WU ◽  
Youmei Li ◽  
Ying Li ◽  
Dong Wang ◽  
Ben Zhong Tang
Keyword(s):  
Hydrogen Peroxide ◽  
Lipid Droplets ◽  
Near Infrared ◽  
Living Cells ◽  
Ros Generation ◽  
Oxygen Species ◽  
Bright Yellow ◽  
Cell Ablation ◽  
Selective Monitoring ◽  
Mitochondria Targeting

Hydrogen peroxide (H2O2), as one kind of key reactive oxygen species (ROS), is mainly produced endogenously primarily in the mitochondria. The selective monitoring of H2O2 in living cells is of great significance for understanding diagnosis and pathogenesis of cancers, the Alzheimer’s disease and diabetes. Here, we constructed a versatile AIE probe, TTPy-H2O2, which achieved superb performances in the specifically visualization of H2O2 specifically in various living cells with mitochondria targeting, excellent biocompatibility and photostability, and remarkable ROS generation ability. Red/near-infrared fluorescence firstly located in the mitochondria could light up lipid droplets with bright yellow fluorescence after responding to the H2O2, which can realize both imaging and photodynamic therapy (PDT) for cancer therapy. <br>

scholarly journals Hydrogen Peroxide-Responsive AIE Probe for Imaging-Guided Organelle Targeting and Photodynamic Cancer Cell Ablation

2020 ◽  
Author(s):  
Qian WU ◽  
Youmei Li ◽  
Ying Li ◽  
Dong Wang ◽  
Ben Zhong Tang
Keyword(s):  
Hydrogen Peroxide ◽  
Lipid Droplets ◽  
Near Infrared ◽  
Living Cells ◽  
Ros Generation ◽  
Oxygen Species ◽  
Bright Yellow ◽  
Cell Ablation ◽  
Selective Monitoring ◽  
Mitochondria Targeting

Hydrogen peroxide (H2O2), as one kind of key reactive oxygen species (ROS), is mainly produced endogenously primarily in the mitochondria. The selective monitoring of H2O2 in living cells is of great significance for understanding diagnosis and pathogenesis of cancers, the Alzheimer’s disease and diabetes. Here, we constructed a versatile AIE probe, TTPy-H2O2, which achieved superb performances in the specifically visualization of H2O2 specifically in various living cells with mitochondria targeting, excellent biocompatibility and photostability, and remarkable ROS generation ability. Red/near-infrared fluorescence firstly located in the mitochondria could light up lipid droplets with bright yellow fluorescence after responding to the H2O2, which can realize both imaging and photodynamic therapy (PDT) for cancer therapy. <br>

scholarly journals Construction of a lysosome-targetable ratiometric fluorescent probe for H2O2 tracing and imaging in living cells and an inflamed model

RSC Advances ◽  
2021 ◽  
Vol 11 (39) ◽  
pp. 24032-24037
Author(s):  
Rongrong Zhou ◽  
Qiyao Peng ◽  
Dan Wan ◽  
Chao Yu ◽  
Yuan Zhang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Fluorescent Probe ◽  
Reactive Oxygen ◽  
Living Cells ◽  
Oxygen Species ◽  
Oxidation Properties ◽  
Ratiometric Fluorescent Probe ◽  
Destructive Oxidation

Hydrogen peroxide (H2O2), an important reactive oxygen species (ROS) with unique destructive oxidation properties, can be produced in lysosomes to fight off pathogens.

scholarly journals Upconversion-based nanosystems for fluorescence sensing of pH and H2O2

2021 ◽  
Author(s):  
Chunning Sun ◽  
Michael Gradzielski
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Excitation Energy ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Fluorescence Sensing ◽  
Living Organisms

Hydrogen peroxide (H2O2), a key reactive oxygen species, plays an important role in living organisms, industrial and environmental fields. Here, a non-contact upconversion nanosystem based on the excitation energy attenuation...

scholarly journals Novel Antioxidant Properties of Doxycycline

2018 ◽  
Vol 19 (12) ◽  
pp. 4078 ◽  
Author(s):  
Dahn Clemens ◽  
Michael Duryee ◽  
Cleofes Sarmiento ◽  
Andrew Chiou ◽  
Jacob McGowan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Chronic Inflammation ◽  
Antioxidant Properties ◽  
Antibacterial Properties ◽  
Reactive Oxygen ◽  
Protein Adducts ◽  
Oxygen Species ◽  
Free System

Doxycycline (DOX), a derivative of tetracycline, is a broad-spectrum antibiotic that exhibits a number of therapeutic activities in addition to its antibacterial properties. For example, DOX has been used in the management of a number of diseases characterized by chronic inflammation. One potential mechanism by which DOX inhibits the progression of these diseases is by reducing oxidative stress, thereby inhibiting subsequent lipid peroxidation and inflammatory responses. Herein, we tested the hypothesis that DOX directly scavenges reactive oxygen species (ROS) and inhibits the formation of redox-mediated malondialdehyde-acetaldehyde (MAA) protein adducts. Using a cell-free system, we demonstrated that DOX scavenged reactive oxygen species (ROS) produced during the formation of MAA-adducts and inhibits the formation of MAA-protein adducts. To determine whether DOX scavenges specific ROS, we examined the ability of DOX to directly scavenge superoxide and hydrogen peroxide. Using electron paramagnetic resonance (EPR) spectroscopy, we found that DOX directly scavenged superoxide, but not hydrogen peroxide. Additionally, we found that DOX inhibits MAA-induced activation of Nrf2, a redox-sensitive transcription factor. Together, these findings demonstrate the under-recognized direct antioxidant property of DOX that may help to explain its therapeutic potential in the treatment of conditions characterized by chronic inflammation and increased oxidative stress.

A Vinyl-Boronate Ester-Based Persulfide Donor Controllable by Hydrogen Peroxide, a Reactive Oxygen Species (ROS)

2018 ◽  
Vol 20 (24) ◽  
pp. 7916-7920 ◽  
Author(s):  
Prerona Bora ◽  
Preeti Chauhan ◽  
Suman Manna ◽  
Harinath Chakrapani
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Boronate Ester

A charge transfer assisted fluorescent probe for selective detection of hydrogen peroxide among different reactive oxygen species

2012 ◽  
Vol 48 (39) ◽  
pp. 4719 ◽  
Author(s):  
Manoj Kumar ◽  
Naresh Kumar ◽  
Vandana Bhalla ◽  
Parduman Raj Sharma ◽  
Yasrib Qurishi
Keyword(s):  
Reactive Oxygen Species ◽  
Hydrogen Peroxide ◽  
Charge Transfer ◽  
Fluorescent Probe ◽  
Reactive Oxygen ◽  
Selective Detection ◽  
Oxygen Species ◽  
A Charge

Colorimetric and Fluorescent Probe for Hypochlorite with High Selectivity

2013 ◽  
Vol 295-298 ◽  
pp. 475-478 ◽  
Author(s):  
Zhi Xiang Han ◽  
Ming Hui Du ◽  
Guo Xi Liang ◽  
Xiang Yang Wu
Keyword(s):  
Reactive Oxygen Species ◽  
Aqueous Solution ◽  
Detection Limit ◽  
Fluorescent Probe ◽  
Rhodamine B ◽  
High Selectivity ◽  
Reactive Oxygen ◽  
Living Cells ◽  
Oxygen Species ◽  
Turn On

Rhodamine B thiohydrazide (RBS) was firstly employed as turn-on fluorescent probe for hypochlorite in aqueous solution and living cells. It exhibits a stable response to hypochlorite from 1.0×10-6to 1.0×10-5M with a detection limit of 3.3×10-7M. The response of this probe to hypochlorite is fast and highly selective compared with other reactive oxygen species (such as.OH,1O2, H2O2) and other common anions (such as X-, ClO2-, ClO4-, NO3-, NO2-, OH-, Ac-, CO32-, SO42-).

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