Synthesis of gallotannin capped iron oxide nanoparticles and their broad spectrum biological applications

ZnO/GO nanocomposites were synthesized and their antibacterial activities assessed against various pathogens. They are potential antibacterial materials and significant anticancer activity against the MCF-7 breast cancer cell line compared to the A549 lung cancer cell line.

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Effects of Sex Steroid Hormones on Corticosteroid-Binding Globulin Gene Expression in Human Endometrial Cancer Cell Line Ishikawa

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/000456329803500507 ◽

1998 ◽

Vol 35 (5) ◽

pp. 637-642 ◽

Cited By ~ 3

Author(s):

Ryou Misao ◽

Yoshihito Nakanishi ◽

Jiro Fujimoto ◽

Teruhiko Tamaya

Keyword(s):

Endometrial Cancer ◽

Mrna Expression ◽

Cell Line ◽

Cancer Cell ◽

Biological Effects ◽

Cancer Cell Line ◽

High Dose ◽

Dependent Manner ◽

Endometrial Cancer Cell ◽

Corticosteroid Binding Globulin

The effect of progestins on intracellular corticosteroid-binding globulin (CBG) mRNA expression in an endometrial cancer cell line (Ishikawa) was examined in an attempt to understand the biological effects of high-dose progestins in the treatment of well-differentiated uterine endometrial cancers. Oestradiol-17β (E2) significantly increased CBG mRNA expression in a dose-dependent manner, while a high dose of progesterone with or without E2 suppressed it significantly. Furthermore, a high dose of progesterone or medroxyprogesterone acetate (MPA) suppressed CBG mRNA expression to a greater degree than did chlormadinone acetate or 17 α-hydroxyprogesterone caproate with or without E2. These findings suggest that the effects of high-dose progestins on cancer cells may be mediated via suppression of intracellular CBG.

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Evaluation of the Cytotoxic Effects of PLGA Coated Iron Oxide Nanoparticles as a Carrier of 5- Fluorouracil and Mega-Voltage X-Ray Radiation in DU145 Prostate Cancer Cell Line

IEEE Transactions on NanoBioscience ◽

10.1109/tnb.2014.2328868 ◽

2014 ◽

Vol 13 (4) ◽

pp. 403-408 ◽

Cited By ~ 19

Author(s):

Zahra Hajikarimi ◽

Samideh Khoei ◽

Sepideh Khoee ◽

Seied Rabi Mahdavi

Keyword(s):

Prostate Cancer ◽

Iron Oxide ◽

Cell Line ◽

Prostate Cancer Cell ◽

Cancer Cell Line ◽

Prostate Cancer Cell Line ◽

Oxide Nanoparticles ◽

Cytotoxic Effects ◽

X Ray ◽

Du145 Prostate Cancer Cell

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Therapeutic efficacy of Phyllanthus emblica-coated iron oxide nanoparticles in A549 lung cancer cell line

Nanomedicine ◽

10.2217/nnm-2019-0111 ◽

2019 ◽

Vol 14 (17) ◽

pp. 2355-2371 ◽

Cited By ~ 1

Author(s):

Shivani Thoidingjam ◽

Ashu Bhan Tiku

Keyword(s):

Lung Cancer ◽

Iron Oxide ◽

Cancer Cells ◽

Cell Line ◽

Therapeutic Efficacy ◽

Cancer Cell Line ◽

Lung Cancer Cell Line ◽

Oxide Nanoparticles ◽

Phyllanthus Emblica ◽

Lung Cancer Cell

Aim: Present work was undertaken to fabricate iron oxide nanoparticles (IONPs) using a green approach for increased therapeutic efficacy. Materials & methods: Two types of IONPs were synthesized, one without any coating (IONPUC) and other coated with Phyllanthus emblica (Amla) fruit extract (IONPA). Both the IONPs were characterized using different techniques and therapeutic efficacy was evaluated in A549 human lung cancer cell line. Results: IONPA were smaller in size with better dispersibility compared with IONPUC. They induced increased reactive oxygen species production, higher DNA damage and apoptosis, which resulted in increased toxicity to cancer cells in comparison to IONPUC. Conclusion: Higher uptake of IONPA and active components coating the surface, may be responsible for the increased therapeutic efficacy in cancer cells.

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