Coating gold nanorods with silica prevents the generation of reactive oxygen species under laser light irradiation for safe biomedical applications

2022 ◽  
Author(s):  
Sarra Mitiche ◽  
Syrine Gueffrache ◽  
Sylvie Marguet ◽  
Jean-Frédéric Audibert ◽  
Robert Bernard Pansu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Gold Nanorods ◽  
Biomedical Applications ◽  
Laser Light ◽  
Reactive Oxygen ◽  
Light Irradiation ◽  
Oxygen Species ◽  
Pulsed Light

Gold nanoparticles can produce reactive oxygen species (ROS) under the action of ultrashort pulsed light. While beneficial for photodynamic therapy, this phenomenon is prohibitive for other biomedical applications such as...

Enhanced Generation of Reactive Oxygen Species Using Gold Nanoparticles Conjugated With Protoporphyrin IX

2010 ◽  
Author(s):  
Maung Kyaw Khaing Oo ◽  
Maria Gomez ◽  
Hongjun Wang ◽  
Henry Du
Keyword(s):  
Reactive Oxygen Species ◽  
Gold Nanoparticles ◽  
Electromagnetic Field ◽  
Photodynamic Therapy ◽  
Protoporphyrin Ix ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Plasmonic Resonance ◽  
Surface Plasmonic Resonance ◽  
Ros Formation

Reactive oxygen species (ROS) is a vital trigger for photodynamic therapy (PDT) of cancer. We report the production of elevated ROS using gold nanoparticles (GNP) (20–100 nm in diameter) conjugated with Protophorphyrin IX (PpIX). The amount of ROS formation increases with the size of the GNP due to enhanced electromagnetic field resulting from localized surface plasmonic resonance.

scholarly journals Mechanisms of Reactive Oxygen Species Generated by Inorganic Nanomaterials for Cancer Therapeutics

2021 ◽  
Vol 9 ◽  
Author(s):  
Lizhen Zhang ◽  
Chengyuan Zhu ◽  
Rongtao Huang ◽  
Yanwen Ding ◽  
Changping Ruan ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Biomedical Applications ◽  
Reactive Oxygen ◽  
Cancer Therapeutics ◽  
Surface Characteristics ◽  
Oxygen Species ◽  
Sonodynamic Therapy ◽  
Dynamic Therapy ◽  
Inorganic Nanomaterials ◽  
Generation Mechanisms

Recently, inorganic nanomaterials have received considerable attention for use in biomedical applications owing to their unique physicochemical properties based on their shapes, sizes, and surface characteristics. Photodynamic therapy (PDT), sonodynamic therapy (SDT), and chemical dynamic therapy (CDT), which are cancer therapeutics mediated by reactive oxygen species (ROS), have the potential to significantly enhance the therapeutic precision and efficacy for cancer. To facilitate cancer therapeutics, numerous inorganic nanomaterials have been developed to generate ROS. This mini review provides an overview of the generation mechanisms of ROS by representative inorganic nanomaterials for cancer therapeutics, including the structures of engineered inorganic nanomaterials, ROS production conditions, ROS types, and the applications of the inorganic nanomaterials in cancer PDT, SDT, and CDT.

scholarly journals Rare-Earth-Doped Calcium Carbonate Exposed to X-ray Irradiation to Induce Reactive Oxygen Species for Tumor Treatment

2019 ◽  
Vol 20 (5) ◽  
pp. 1148 ◽  
Author(s):  
Chun-Chen Yang ◽  
Wei-Yun Wang ◽  
Feng-Huei Lin ◽  
Chun-Han Hou
Keyword(s):  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Tumor Growth ◽  
Light Source ◽  
Reactive Oxygen ◽  
Blood Analysis ◽  
Oxygen Species ◽  
Tumor Treatment ◽  
X Ray

Conventional photodynamic therapy (PDT) is limited by its penetration depth due to the photosensitizer and light source. In this study, we developed X-ray induced photodynamic therapy that applied X-ray as the light source to activate Ce-doped CaCO3 (CaCO3:Ce) to generate an intracellular reactive oxygen species (ROS) for killing cancer cells. The A549 cell line was used as the in vitro and in vivo model to evaluate the efficacy of X-ray-induced CaCO3:Ce. The cell viability significantly decreased and cell cytotoxicity obviously increased with CaCO3:Ce exposure under X-ray irradiation, which is less harmful than radiotherapy in tumor treatment. CaCO3:Ce produced significant ROS under X-ray irradiation and promoted A549 cancer cell death. CaCO3:Ce can enhance the efficacy of X-ray induced PDT, and tumor growth was inhibited in vivo. The blood analysis and hematoxylin and eosin stain (H&E) stain fully supported the safety of the treatment. The mechanisms underlying ROS and CO2 generation by CaCO3:Ce activated by X-ray irradiation to induce cell toxicity, thereby inhibiting tumor growth, is discussed. These findings and advances are of great importance in providing a novel therapeutic approach as an alternative tumor treatment.

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