Enhanced Generation of Reactive Oxygen Species Using Gold Nanoparticles Conjugated With Protoporphyrin IX

2010 ◽  
Author(s):  
Maung Kyaw Khaing Oo ◽  
Maria Gomez ◽  
Hongjun Wang ◽  
Henry Du
Keyword(s):  
Reactive Oxygen Species ◽  
Gold Nanoparticles ◽  
Electromagnetic Field ◽  
Photodynamic Therapy ◽  
Protoporphyrin Ix ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Plasmonic Resonance ◽  
Surface Plasmonic Resonance ◽  
Ros Formation

Reactive oxygen species (ROS) is a vital trigger for photodynamic therapy (PDT) of cancer. We report the production of elevated ROS using gold nanoparticles (GNP) (20–100 nm in diameter) conjugated with Protophorphyrin IX (PpIX). The amount of ROS formation increases with the size of the GNP due to enhanced electromagnetic field resulting from localized surface plasmonic resonance.

Coating gold nanorods with silica prevents the generation of reactive oxygen species under laser light irradiation for safe biomedical applications

2022 ◽  
Author(s):  
Sarra Mitiche ◽  
Syrine Gueffrache ◽  
Sylvie Marguet ◽  
Jean-Frédéric Audibert ◽  
Robert Bernard Pansu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Gold Nanorods ◽  
Biomedical Applications ◽  
Laser Light ◽  
Reactive Oxygen ◽  
Light Irradiation ◽  
Oxygen Species ◽  
Pulsed Light

Gold nanoparticles can produce reactive oxygen species (ROS) under the action of ultrashort pulsed light. While beneficial for photodynamic therapy, this phenomenon is prohibitive for other biomedical applications such as...

scholarly journals Intradialytic granulocyte reactive oxygen species production: a prospective, crossover trial.

1993 ◽  
Vol 4 (2) ◽  
pp. 178-186 ◽  
Author(s):  
J Himmelfarb ◽  
K A Ault ◽  
D Holbrook ◽  
D A Leeber ◽  
R M Hakim
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Fold Increase ◽  
Ros Production ◽  
Oxygen Species ◽  
Susceptibility To Infection ◽  
Flow Cytometric ◽  
Ros Formation ◽  
Dialysis Membranes ◽  
Species Production

By the use of flow cytometric techniques, this prospective, randomized crossover study was designed to analyze intradialytic granulocyte reactive oxygen species (ROS) formation in whole blood with complement-activating and noncomplement-activating hollow fiber membranes. Dialysis with a complement-activating membrane resulted in a 6.5-fold increase in granulocyte hydrogen peroxide production 15 min after dialysis initiation and remained significantly elevated (P < 0.01) through the first 30 min with this membrane in comparison to both predialysis values and simultaneous values with a noncomplement-activating membrane. Further studies demonstrated that blood obtained at 15 min with a complement-activating membrane generated significantly less granulocyte ROS production in response to Staphylococcus aureus incubation than blood obtained either predialysis or at the same time in dialysis with a noncomplement-activating membrane. Both complement-activating and noncomplement-activating dialysis membranes caused slightly decreased granulocyte responsiveness to phorbol myristate acetate. It was concluded that hemodialysis with complement-activating membranes results in increased granulocyte ROS production and decreased responsiveness to S. aureus challenge during the dialysis procedure. These results document the potential role of ROS in hemodialysis-associated pathology and susceptibility to infection.

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