scholarly journals The ocean pharmacy: A treasure chest of new drug leads

2012 ◽  
Vol 34 (1) ◽  
pp. 16-21 ◽  
Author(s):  
Andrew Mearns Spragg ◽  
Simon G. Best
Keyword(s):  
Natural Products ◽  
Intellectual Property ◽  
Pharmaceutical Industry ◽  
Combinatorial Chemistry ◽  
Low Cost ◽  
Regulatory Requirements ◽  
Synthetic Compounds ◽  
New Drug ◽  
Treasure Chest ◽  
Drug Leads

Over the last 20 years, the pharmaceutical industry has seen a decrease in discovery and success based on computational and combinatorial chemistry, and an increase in base costs imposed by increasing regulatory requirements and a higher rate of failures during the development process1. Couple this to the potential of structural, hence intellectual property overlap between libraries of synthetic compounds and the need for low-cost, scalable and chemically unique new scaffolds, the pharmaceutical industry is starting to re-evaluate the potential of natural products to provide the industry with new drug leads.

scholarly journals UsingDrosophilaas a platform for drug discovery from natural products in Parkinson's disease

MedChemComm ◽  
2019 ◽  
Vol 10 (6) ◽  
pp. 867-879 ◽  
Author(s):  
Urmila Maitra ◽  
Lukasz Ciesla
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Natural Products ◽  
Drug Discovery ◽  
Therapeutic Potential ◽  
Natural Extracts ◽  
New Drug ◽  
Screening Platform ◽  
Drug Leads

The review provides an overview of discovery of new drug leads from natural extracts usingDrosophilaas a screening platform to evaluate the therapeutic potential of phytochemicals against Parkinson's disease.

scholarly journals Regulatory compliances in development of commercial scale process of Nanoparticles (Liposomes and Niosomes) in pharmaceutical industry : A review

2020 ◽  
Vol 11 (4) ◽  
pp. 7094-7101
Author(s):  
Daka Nagarjuna Reddy ◽  
Mahaveer Singh ◽  
Birendra Shrivastava ◽  
Ravi Kumar Konda
Keyword(s):  
Pharmaceutical Industry ◽  
Review Process ◽  
Indian Market ◽  
Regulatory Requirements ◽  
New Drug ◽  
Industry Study ◽  
Review Study ◽  
Critical Overview ◽  
Abbreviated New Drug Applications ◽  
Regulatory Landscape

The main objective of this review work was designed to explore the regulatory environments that govern the pharmaceutical industry. Main objective of regulatory department is to maintain the quality, safety and efficacy of the medical products it also ensures the standard of medicinal product for sales, importing and manufacturing. The biggest challenge faced by the pharma manufactures is Scaling up their production. Our review process focuses on regulatory requirements concerning Liposomes and Niosomes and their limitations in respect to industrial applicability. In detail explanation of what type of information should be submitted to FDA and EU in new drug applications (NDAs) or abbreviated new drug applications (ANDAs). By comparing these two developed regulatory markets we can build a strong regulation in Indian market on Liposomes and Niosomes. The review study deals with the sound knowledge about regulatory landscape that governs the pharmaceutical industry. Study describes in depth about liposomes and niosomes delivery systems and gives a critical overview of the current regulatory landscape surrounding commercialization efforts of higher-level complexity systems, the expected requirements and the hurdles faced by companies seeking to bring novel liposome and noisome based systems for clinical use to market.

scholarly journals The Evolving Role of Natural Products from the Tropical Rainforests as a Replenishable Source of New Drug Leads

10.5772/59603 ◽  
2015 ◽  
Author(s):  
Ibrahim Jantan ◽  
Syed Nasir Abbas Bukhari ◽  
Mohamed Ali Seyed Mohamed ◽  
Lam Kok Wai ◽  
Mohammed Ahmed Mesaik
Keyword(s):  
Natural Products ◽  
Tropical Rainforests ◽  
New Drug ◽  
Drug Leads

scholarly journals In silico study of natural compounds from sesame against COVID-19 by targeting Mpro, PLpro and RdRp

RSC Advances ◽  
2021 ◽  
Vol 11 (36) ◽  
pp. 22398-22408
Author(s):  
Ahmed E. Allam ◽  
Yhiya Amen ◽  
Ahmed Ashour ◽  
Hamdy K. Assaf ◽  
Heba Ali Hassan ◽  
...  
Keyword(s):  
Natural Products ◽  
Traditional Medicine ◽  
In Silico ◽  
Natural Compounds ◽  
New Drug ◽  
In Silico Study ◽  
Drug Leads ◽  
Promising Source

Natural products and traditional medicine products with known safety profiles are a promising source for the discovery of new drug leads.

Antitubercular Marine Natural Products

2018 ◽  
Vol 25 (20) ◽  
pp. 2304-2328 ◽  
Author(s):  
Lishu Wang ◽  
Jungfeng Wang ◽  
Juan Liu ◽  
Yonghong Liu
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Antitubercular Activity ◽  
Marine Resources ◽  
Drug Candidates ◽  
New Drug ◽  
Chemical Constitution

Due to the importance of nature as a source of new drug candidates, the purpose of this article is to emphasize the marine natural products, which exhibit antitubercular activity, published between January 2000 and May 2016, with 138 quotations to 250 compounds obtained from marine resources. These metabolites are organized by chemical constitution and named as simple alkyl lipids derivatives, aromatics derivatives, peptides, alkaloids, terpenoids, steroids, macrolides, and polycyclic polyketides.

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