scholarly journals The relationship of the rat brain 68 kDa microtubule-associated protein with synaptosomal plasma membranes and with the Drosophila 70 kDa heat-shock protein

1984 ◽  
Vol 224 (2) ◽  
pp. 677-680 ◽  
Author(s):  
L Lim ◽  
C Hall ◽  
T Leung ◽  
S Whatley
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Rat Brain ◽  
Plasma Membranes ◽  
Brain Mrna ◽  
Synaptic Structures ◽  
Relationship Of ◽  
The Relationship ◽  
The Brain ◽  
Synaptosomal Plasma Membranes

A protein of molecular mass 68 kDa and pI5.6 is a major translation product of rat brain mRNA [Hall, Mahadevan, Whatley, Biswas & Lim (1984) Biochem. J. 219, 751-761]. In the rat brain this protein was associated with microtubule preparations and was present together with tubulin as a component of the synaptosomal plasma membranes, synaptic vesicles and post-synaptic structures. The brain mRNA for this protein was found to hybridize specifically to the Drosophila gene for the 70 kDa heat-shock protein, thus enabling its rapid isolation.

Polymeric Nanoparticles for Brain Drug Delivery - A Review

2020 ◽  
Vol 21 (9) ◽  
pp. 649-660
Author(s):  
Subashini Raman ◽  
Syed Mahmood ◽  
Ayah R. Hilles ◽  
Md Noushad Javed ◽  
Motia Azmana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Polymeric Nanoparticles ◽  
Drug Loading ◽  
Preparation Methods ◽  
Brain Drug Delivery ◽  
Polymeric Nanoparticle ◽  
Relationship Of ◽  
The Relationship ◽  
The Brain

Background: Blood-brain barrier (BBB) plays a most hindering role in drug delivery to the brain. Recent research comes out with the nanoparticles approach, is continuously working towards improving the delivery to the brain. Currently, polymeric nanoparticle is extensively involved in many therapies for spatial and temporal targeted areas delivery. Methods: We did a non-systematic review, and the literature was searched in Google, Science Direct and PubMed. An overview is provided for the formulation of polymeric nanoparticles using different methods, effect of surface modification on the nanoparticle properties with types of polymeric nanoparticles and preparation methods. An account of different nanomedicine employed with therapeutic agent to cross the BBB alone with biodistribution of the drugs. Results: We found that various types of polymeric nanoparticle systems are available and they prosper in delivering the therapeutic amount of the drug to the targeted area. The effect of physicochemical properties on nanoformulation includes change in their size, shape, elasticity, surface charge and hydrophobicity. Surface modification of polymers or nanocarriers is also vital in the formulation of nanoparticles to enhance targeting efficiency to the brain. Conclusion: More standardized methods for the preparation of nanoparticles and to assess the relationship of surface modification on drug delivery. While the preparation and its output like drug loading, particle size, and charge, permeation is always conflicted, so it requires more attention for the acceptance of nanoparticles for brain delivery.

scholarly journals The relationship of morphometric changes of the brain with IL-6 levels, systemic inflammation and immune disturbances in the patients with schizophrenia

2021 ◽  
Vol 190 ◽  
pp. 553-559
Author(s):  
Irina K. Malashenkova ◽  
Vadim L. Ushakov ◽  
Sergey A. Krynskiy ◽  
Daniil P. Ogurtsov ◽  
Nikita A. Khailov ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Relationship Of ◽  
The Relationship ◽  
The Brain

scholarly journals Relationship of the 90-kDa murine heat shock protein to the untransformed and transformed states of the L cell glucocorticoid receptor.

1987 ◽  
Vol 262 (15) ◽  
pp. 6986-6991 ◽  
Author(s):  
E R Sanchez ◽  
S Meshinchi ◽  
W Tienrungroj ◽  
M J Schlesinger ◽  
D O Toft ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Glucocorticoid Receptor ◽  
L Cell ◽  
Relationship Of

Selective postmortem degradation of inducible heat shock protein 70 (hsp70) mRNAs in rat Brain

1994 ◽  
Vol 14 (4) ◽  
pp. 341-357 ◽  
Author(s):  
Sibile Pardue ◽  
Anton L. Zimmerman ◽  
Marcelle Morrison-Bogorad
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Rat Brain ◽  
Heat Shock Protein 70

ACTH SOLUBILIZATION OF A KINASE FROM RAT BRAIN SYNAPTOSOMAL PLASMA MEMBRANES

1981 ◽  
Vol 9 (2) ◽  
pp. 356P-356P
Author(s):  
V. J. Aloyo ◽  
H. Zwiers ◽  
P. R. Bär ◽  
W. H. Gispen
Keyword(s):  
Rat Brain ◽  
Plasma Membranes ◽  
Synaptosomal Plasma Membranes
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