Regulation of Ca2+-dependent protein turnover in skeletal muscle by thyroxine
Keyword(s):
Dantrolene, an agent that inhibits Ca2+ mobilization, improved protein balance in skeletal muscle, as thyroid status was increased, by altering rates of protein synthesis and degradation. Thyroxine (T4) caused increases in protein degradation that were blocked by leupeptin, a proteinase inhibitor previously shown to inhibit Ca2+-dependent non-lysosomal proteolysis in these muscles. In addition, T4 abolished sensitivity to the lysosomotropic agent methylamine and the autophagy inhibitor 3-methyladenine, suggesting that T4 inhibits autophagic/lysosomal proteolysis.
1996 ◽
Vol 270
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pp. R1231-R1239
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1988 ◽
Vol 123
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pp. 640
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2001 ◽
Vol 25
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pp. 1373-1382
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1998 ◽
Vol 55
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pp. 1534-1544
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2020 ◽
Vol 129
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pp. 36-46
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