Mining for survival genes

2006 ◽  
Vol 34 (6) ◽  
pp. 1307-1309 ◽  
Author(s):  
V.L. Dawson ◽  
T.M. Dawson

Many stressful, but not lethal, stimuli activate endogenous protective mechanisms that significantly decrease the degree of injury to subsequent injurious stimuli. This protective mechanism is termed preconditioning and tolerance. It occurs across organ systems including the brain and nervous system. Preconditioning has been investigated in cell and animal models and recently been shown to potentially occur in human brain. Learning more about these powerful endogenous neuroprotective mechanisms could help identify new approaches to treat patients with stroke and other central nervous system disorders or injury. Cell and animal models are helping us to better understand the network response of gene and protein expression that activates the neuroprotective response.

Author(s):  
Eduardo D. Gomes ◽  
Sandra Barata-Antunes ◽  
Andreia Teixeira-Castro ◽  
Rita C. Assunção-Silva ◽  
Cláudia R. Marques ◽  
...  

1997 ◽  
Vol 86 (04) ◽  
pp. 201-206 ◽  
Author(s):  
José-Leonel Torres ◽  
Guadalupe Ruiz

AbstractThe effect of Nux vomica on the EEGs of rats during sleep was quantified in terms of suitable statistical parameters that showed systematic changes after the homoeopathic stimulus. Our results are consistent with a decrease in the coherence of the brain signal compared to results obtained by using either the solvent on its own or pure water, and can be interpreted in terms of irritation of the animals' central nervous system due to the applied stimulus. This coincides with the effect Nux vomica has on healthy humans and suggests a means of characterizing the homoeopathic effect in physicochemical terms, based on parameters similar to those found appropriate in this study, calculated for physiological data from animal models for specific conditions. It also lends scientific support to ongoing attempts to extend Hahnemann's principles of similitude and potentiation beyond their original context, into the realm of veterinary medicine.


1978 ◽  
Vol 2 (3) ◽  
pp. 313-325 ◽  
Author(s):  
George R. Breese ◽  
Robert A. Mueller ◽  
Richard B. Mailman ◽  
Gerald D. Frye ◽  
Richard A. Vogel

Author(s):  
Kartik Pandya ◽  
Chintan Aundhia ◽  
Avinash Seth ◽  
Nirmal Shah ◽  
Dipti Gohil ◽  
...  

Central nervous system (CNS) disorder is the world’s leading cause of disability and account of more hospitalizations. Central nervous system disorders are a group of neurological disorder that affect the structure or function of the brain or spinal cord. Depression (major depressive disorder or clinical depression) is a common but serious mood disorder. It causes severe symptoms that affect how you feel, think, and handle daily activities, such as sleeping, eating, or working. The aim of treatment is release of neurotrophic proteins in the brain that can help to rebuild the hippocampus that has been reduced due to depression and to optimize patients’ physical, psychological and social functioning. This review presents a brief summary on psychological implications of living with depression, pathogenesis, diagnosis, causes, sign and symptoms and treatments associated with depression.


2021 ◽  
Vol 11 (5) ◽  
pp. 199-207
Author(s):  
VENESSA NATH ◽  
PARISHMITA BURAGOHAIN ◽  
HEMANTA KUMAR SHARMA

Background: Central nervous system (CNS) disorders are a group of neurological disorders concerned with behaviour, coordination and functioning of the brain and the spinal cord. The CNS is the site of processing various informations. It interprets and evaluates the information and as result, the CNS responds accordingly and controls the body. Any defects or disorders of the Central nervous system may cause degeneration of the organs and tissues associated with it, loss of coordination, paralysis, etc. These disorders may be hereditary or due to injuries to the brain and spinal cord. Although, these disorders are being cured with medicaments, many plant species are also seen to be effective in its treatment. Objective: the main objective of this article is to underline the potentials and the needs for the documentation of the ecological knowledge of herbal medicines of the north east India region, necessary for the greater well-being of mankind in the prevention and cure of CNS disorders. Methods: an extensive literature survey was carried out through various databases like Google Scholar, Pubmed, Sciencedirect etc to support this review. All the collected information was analyzed accordingly and the plants were enlisted based on the classes of CNS disorders for which they are used. Result and discussion: from the survey of the database being collected, it was found that many traditional and local plants of the northeast India region are therapeutically effective in the treatment and cure of many Central nervous system disorders. Conclusion:-It is now an accepted fact that many traditional plants found in the Northeast India have been acceptable within the human body and hence these can be used to replace many expensive medications available in the market. Keywords:  Medicinal plants; Central Nervous System; CNS disorders; Northeast India; Plant extract


Arkus ◽  
2021 ◽  
Vol 3 (1) ◽  
pp. 189-190
Author(s):  
Andika Okparasta

Encephalitis is an inflammatory process of the brain that attacks the central nervous system and can cause neurological dysfunction. Encephalitis is mostly caused by viruses, but in some cases the etiology is unknown. Autoimmune encephalitis occurs due to autoantibody interactions characterized by symptoms of central nervous system disorders. Clinical symptoms are quite specific, but there are criteria that must be met to make a diagnosis and additional investigations if needed. Treatment options for autoimmune encephalitis range from agents that suppress the immune system broadly to agents that specifically target antibody-mediated pathogenesis.


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