Nonsense-mediated mRNA decay
2008 ◽
Vol 36
(3)
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pp. 514-516
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Keyword(s):
Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes premature from normal translation termination? Surprisingly, in mammalian cells, PTC recognition is linked to pre-mRNA splicing. Here, we review the current understanding in view of recent developments.
2007 ◽
Vol 27
(16)
◽
pp. 5630-5638
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2005 ◽
Vol 17
(3)
◽
pp. 309-315
◽
2009 ◽
Vol 29
(13)
◽
pp. 3517-3528
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2017 ◽
2008 ◽
Vol 36
(3)
◽
pp. 497-501
◽
2008 ◽
Vol 36
(4)
◽
pp. 698-700
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2021 ◽
2004 ◽
Vol 24
(17)
◽
pp. 7483-7490
◽
2006 ◽
Vol 26
(14)
◽
pp. 5237-5248
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