Molecular interactions shaping the tetraspanin web

2017 ◽  
Vol 45 (3) ◽  
pp. 741-750 ◽  
Author(s):  
Sjoerd J. van Deventer ◽  
Vera-Marie E. Dunlock ◽  
Annemiek B. van Spriel
Keyword(s):  
Molecular Interactions ◽  
Intracellular Signaling ◽  
Spatial Organization ◽  
Complex Mixture ◽  
Point Of View ◽  
Intramolecular Interactions ◽  
Fundamental Understanding ◽  
High Degree ◽  
Partner Proteins ◽  
Insight Into

To facilitate the myriad of different (signaling) processes that take place at the plasma membrane, cells depend on a high degree of membrane protein organization. Important mediators of this organization are tetraspanin proteins. Tetraspanins interact laterally among themselves and with partner proteins to control the spatial organization of membrane proteins in large networks called the tetraspanin web. The molecular interactions underlying the formation of the tetraspanin web were hitherto mainly described based on their resistance to different detergents, a classification which does not necessarily correlate with functionality in the living cell. To look at these interactions from a more physiological point of view, this review discusses tetraspanin interactions based on their function in the tetraspanin web: (1) intramolecular interactions supporting tetraspanin structure, (2) tetraspanin–tetraspanin interactions supporting web formation, (3) tetraspanin–partner interactions adding functional partners to the web and (4) cytosolic tetraspanin interactions regulating intracellular signaling. The recent publication of the first full-length tetraspanin crystal structure sheds new light on both the intra- and intermolecular tetraspanin interactions that shape the tetraspanin web. Furthermore, recent molecular dynamic modeling studies indicate that the binding strength between tetraspanins and between tetraspanins and their partners is the complex sum of both promiscuous and specific interactions. A deeper insight into this complex mixture of interactions is essential to our fundamental understanding of the tetraspanin web and its dynamics which constitute a basic building block of the cell surface.

scholarly journals Systemic Lupus Erythematosus before and after COVID-19 Lockdown: How the Perception of Disease Changes through the Lenses of Narrative Medicine

Healthcare ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 726
Author(s):  
Fulvia Ceccarelli ◽  
Venusia Covelli ◽  
Giulio Olivieri ◽  
Francesco Natalucci ◽  
Fabrizio Conti
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Narrative Medicine ◽  
Good Control ◽  
Final Analysis ◽  
Point Of View ◽  
Systemic Lupus ◽  
Before And After ◽  
Text Content ◽  
Insight Into

Background: The COVID-19 pandemic contributes to the burden of living with different diseases, including Systemic Lupus Erythematosus (SLE). We described, from a narrative point of view, the experiences and perspectives of Italian SLE adults during the COVID-19 emergency, by distinguishing the illness experience before and after the lockdown. Methods: Fifteen patients were invited to participate. Illness narratives were collected between 22 and 29 March 2020 using a written modality to capture patients’ perspectives before and after the COVID-19 lockdown. We performed a two-fold analysis of collected data by distinguishing three narrative types and a qualitative analysis of content to identify the relevant themes and sub-themes reported. Results: Eight narratives included in the final analysis (mean length 436.9 words) have been written by eight females (mean age 43.3 ± 9.9 years, mean disease duration 13.1 ± 7.4 years). Six patients provided a quest narrative, one a chaos and the remaining one a restitution narrative. By text content analysis, we identified specific themes, temporally distinct before and after the lockdown. Before COVID-19, all the patients referred to a good control of disease, however the unexpected arrival of the COVID-19 emergency broke a balance, and patients perceived the loss of health status control, with anxiety and stress. Conclusions: We provided unique insight into the experiences of people with SLE at the time of COVID-19, underlining the perspective of patients in relation to the pandemic.

scholarly journals Sex Work in Slovenia: Assessing the Needs of Sex Workers

2021 ◽  
pp. 136078042110184
Author(s):  
Leja Markelj ◽  
Alisa Selan ◽  
Tjaša Dolinar ◽  
Matej Sande
Keyword(s):  
Needs Assessment ◽  
Sex Work ◽  
Sex Workers ◽  
Point Of View ◽  
Social Distress ◽  
Legal Advice ◽  
The Law ◽  
Client Relations ◽  
Insight Into

The research comprehensively identifies the needs and problems of sex workers in Slovenia from the point of view of three groups of actors in a decriminalized setting. The objective of the rapid needs assessment was to identify the needs of sex workers as perceived by themselves. In order to gain a deeper insight into this topic, we analyzed the functioning of the organizations working with the population, and examined the perspective of the clients. The results of the study show that no aid programmes have been developed for sex workers, even though organizations from various fields often come in contact with this population. Sex workers express the need to be informed about various topics (health, the law, legal advice) and emphasize client relations as the primary issue. The findings indicate the need for the development of a specialized aid programmes to address the fields of advocacy, reducing social distress and providing psychosocial assistance.

Resistance to Outflow of Cerebrospinal Fluid Determined by Bolus Injection Technique and Constant Rate Steady State Infusion in Humans

Neurosurgery ◽  
1985 ◽  
Vol 16 (3) ◽  
pp. 336-340 ◽  
Author(s):  
Michael Kosteljanetz
Keyword(s):  
Cerebrospinal Fluid ◽  
Steady State ◽  
Bolus Injection ◽  
Point Of View ◽  
Injection Technique ◽  
Communicating Hydrocephalus ◽  
Constant Rate ◽  
High Degree ◽  
Infusion Technique

Abstract Two methods for the determination of resistance to the outflow of cerebrospinal fluid, the bolus injection technique and the constant rate steady state infusion technique, were compared. Thirty-two patients with a variety of intracranial diseases (usually communicating hydrocephalus) were studied. There was a high degree of correlation between the resistance values obtained with the two methods, but values based on the bolus injection technique were systematically and statistically significantly lower than those obtained with the constant rate infusion test. From a practical point of view. both methods were found to be applicable in a clinical setting.

A GALLERY OF CHUA ATTRACTORS PART VI

2007 ◽  
Vol 17 (06) ◽  
pp. 1801-1910 ◽  
Author(s):  
ELEONORA BILOTTA ◽  
GIANPIERO DI BLASI ◽  
FAUSTO STRANGES ◽  
PIETRO PANTANO
Keyword(s):  
Phase Space ◽  
Spatial Organization ◽  
Fractal Dimensions ◽  
Point Of View ◽  
Experimental Investigations ◽  
Technical Data ◽  
Future Studies ◽  
Small Set ◽  
Methodological Approaches

In this article, we conclude our series of papers on the analysis and visualization of Chua attractors and their generalizations. We present a gallery of 144 n-scroll, 15 hyperchaotic and 37 synchronized systems. Along with time series and FFT we provide 3D visualizations; for some attractors we also supply Lyapunov coefficients and fractal dimensions. The goal in constructing our Gallery has been to make the general public aware of the enormous variety of chaotic phenomena and to change the widespread impression that they are isolated rarities. The Gallery provides a valuable collection of images and technical data which can be used to analyze these phenomena and to reproduce them in future studies. From a scientific point of view, we have tried to identify new methodological approaches to the study of chaos, opening nontraditional perspectives on the complexity of this domain. In our papers, we have discussed a broad range of topics, ranging from techniques for visualizing Chua attractors to computational methods allowing us to make a statistical classification of attractors' positions in phase space and to describe the evolutionary processes through which their shapes change over time. We see these processes as analogous to population dynamics in artificial environments. Within these environments, we use experimental methods to identify the models which guide morphogenetic change and which organize genetic landscapes in parameter space. This paper is organized as follows. First, we provide formal descriptions of the attractors generated by n-scroll, hyperchaotic and synchronized systems. The next section describes a Gallery of Chua attractors, generated by gradually varying the parameters and analyzing the resulting bifurcation maps. We then describe software tools allowing us to perform statistical analyses on selected sets of attractors, to visualize them, to explore their organization in phase space, and to conduct experimental investigations of the morphogenetic processes through which a small set of base attractors can generate a broad range of different forms. In the last section, we describe the creation of a Virtual 3D Gallery displaying some of the attractors we have presented in our six papers. The attractors are organized by theme, as they might be in a museum. The environment allows users to explore the attractors, interact with shapes, listen to music and sounds generated by the attractors, change their spatial organization, and create new shapes. To complete the paper — and the series — we propose a number of general conclusions.

Gaseous Cyclodextrin-closo-Dodecaborate Complexes ΧCD·[B12X12]2- (Χ = α, β, γ; X = F, Cl, Br, I): Electronic Structures and Intramolecular Interactions

2021 ◽  
Author(s):  
Yanrong Jiang ◽  
Qinqin Yuan ◽  
Wenjin Cao ◽  
Markus Rohdenburg ◽  
Marc C. Nierstenhöfer ◽  
...  
Keyword(s):  
Electronic Structure ◽  
Supramolecular Chemistry ◽  
Inclusion Complexes ◽  
Electronic Structures ◽  
Systematic Investigation ◽  
Intramolecular Interactions ◽  
Fundamental Understanding

A fundamental understanding of cyclodextrin-closo-dodecaborate inclusion complexes has become of great interest in supramolecular chemistry. Herein, we report a systematic investigation on the electronic structure and intramolecular interactions of perhalogenated...

Testing of Automated Systems from the Safety Point of View

1981 ◽  
Vol 18 (03) ◽  
pp. 234-244
Author(s):  
John D. Vitkauskas ◽  
John R. Peters
Keyword(s):  
Test Procedure ◽  
Coast Guard ◽  
Point Of View ◽  
Automated Systems ◽  
Testing Procedures ◽  
Procedure Guidelines ◽  
Safety Systems ◽  
Insight Into

The Coast Guard NVIC 1–69 has provided guidelines for the design of automated systems so that human surveillance can be reduced without jeopardizing the vessel. An integral part of these guidelines is the preparation of a Test Procedure which periodically tests the vital safety systems to increase the probability that they will function properly when called on. However, the Test Procedure guidelines are general and subject to wide interpretation. This paper attempts to provide some insight into what needs to be periodically tested, why the testing is required, and what techniques are acceptable, at the same time stressing the need for efficient testing. Some examples are also provided of testing procedures that have been found to be efficient and sufficiently comprehensive.

Reconsidering Kant’s Rejection of Indirect Arguments in Transcendental Philosophy

2021 ◽  
pp. 1-19
Author(s):  
Marcel Buß
Keyword(s):  
Immanuel Kant ◽  
Explanatory Power ◽  
Transcendental Philosophy ◽  
Point Of View ◽  
Transcendental Arguments ◽  
Mathematical Proofs ◽  
Law Of Excluded Middle ◽  
The Law ◽  
Excluded Middle ◽  
Insight Into

Abstract Immanuel Kant states that indirect arguments are not suitable for the purposes of transcendental philosophy. If he is correct, this affects contemporary versions of transcendental arguments which are often used as an indirect refutation of scepticism. I discuss two reasons for Kant’s rejection of indirect arguments. Firstly, Kant argues that we are prone to misapply the law of excluded middle in philosophical contexts. Secondly, Kant points out that indirect arguments lack some explanatory power. They can show that something is true but they do not provide insight into why something is true. Using mathematical proofs as examples, I show that this is because indirect arguments are non-constructive. From a Kantian point of view, transcendental arguments need to be constructive in some way. In the last part of the paper, I briefly examine a comment made by P. F. Strawson. In my view, this comment also points toward a connection between transcendental and constructive reasoning.

The Degree Of Applying The Thinking Skills In Teaching Physical Education In Public Schools In Palestine From The Perspectives Of Teachers Of Physical Education Themselves

2020 ◽  
Vol 8 (3) ◽  
pp. 61-73
Author(s):  
Islam Abbas ◽  
Farah Naseer
Keyword(s):  
Public Schools ◽  
Physical Education ◽  
Reflective Thinking ◽  
Training Programs ◽  
Thinking Skills ◽  
Point Of View ◽  
High Degree

This study aimed to identify the degree of applying the thinking skills in teaching physical education in public schools in Palestine from the perspectives of teachers of physical education themselves. The study found that the degree of applying the thinking skills in the field of thinking during the event received the highest degree of approval from the point of view of the teachers of physical education, followed by the field of thinking of the event in the second place. The field of reflective thinking in general received a high degree of approval, with a percentage of 73.3%. The study also focused on the preparation of teachers with a high awareness in the use of reflective thinking skills, and the need to prepare training programs for students in the field of reflective thinking to help them solve their problems No compound skills.

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