The ER stress-autophagy axis: implications for cognitive dysfunction in diabetes mellitus
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Abstract Unfolded protein response (UPR) often coordinates with autophagy to maintain cellular proteostasis. Disturbance of proteostasis correlates with diseases including diabetes and neurological complications. In a recent article in Clinical Science, Kong et al. highlighted the critical role of endoplasmic reticulum (ER) stress-autophagy axis in maintaining cognitive functions and provided pharmacological evidence with respect to cognitive improvements in a diabetic mouse model. These novel findings present new insights into the pathological mechanisms and therapeutic implications with the ER stress modulators in diabetes-related cognitive dysfunction.
2018 ◽
Vol 60
(4)
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pp. 285-297
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2017 ◽
Vol 312
(3)
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pp. H355-H367
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2017 ◽
Vol 5
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