Bone metabolism markers and bone mass in healthy pubertal boys and girls

AbstractWe aimed to examine the associations of adipocytokines and circulating bone metabolism markers with bone mineral parameters in early pubertal boys with different physical activity level.Eighty-six early pubertal boys were divided into active and non-active boys according to the accumulated moderate-to-vigorous physical activity (MVPA) level. Body composition and bone mineral parameters were assessed and testosterone, leptin, adiponectin, osteocalcin (OC), and C-terminal telopeptide of type I collagen (CTX) were measured.Active subjects had significantly lower (p<0.05) body mass, body mass index (BMI), fat mass (FM), leptin, and sedentary time values, while non-active subjects had lower (p<0.05) vigorous physical activity level and femoral neck bone mineral density (FN-BMD). OC contributed to the models in physically active group and explained 6.6% and 9.7% of variance in whole body (WB) [F(5,44)=10.847; p<0.001] and lumbar spine bone mineral content (LS-BMC) [F(5,44)=4.158; p=0.004], respectively. No other biochemical parameters were found to be related to bone mineral parameters in either the active or non-active group.Bone metabolism markers were positively correlated with bone mineral values only in active pubertal boys. Leptin and adiponectin were not related to bone mineral parameters in active and non-active pubertal boys.

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Effects of honey supplementation combined with different jumping exercise intensities on bone mass, serum bone metabolism markers and gonadotropins in female rats

BMC Complementary and Alternative Medicine ◽

10.1186/1472-6882-14-126 ◽

2014 ◽

Vol 14 (1) ◽

Cited By ~ 8

Author(s):

Maryam Mosavat ◽

Foong Kiew Ooi ◽

Mahaneem Mohamed

Keyword(s):

Bone Mass ◽

Bone Metabolism ◽

Female Rats ◽

Bone Metabolism Markers ◽

Jumping Exercise

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Development of a Chemiluminescence Assay for Total N-Terminal Propeptide of Type I Collagen and Its Evaluation in Lung Transplantation

Journal of Analytical Methods in Chemistry ◽

10.1155/2022/2711414 ◽

2022 ◽

Vol 2022 ◽

pp. 1-9

Author(s):

Shuang Han ◽

Fang Gong ◽

Yifeng Xue ◽

Chunxin Wang ◽

Xiaowei Qi

Keyword(s):

Bone Mass ◽

Lung Transplantation ◽

Bone Metabolism ◽

Limit Of Detection ◽

Expression System ◽

Type I ◽

Mineral Density ◽

Total N ◽

Bone Metabolism Markers ◽

Chemiluminescence Assay

Serum P1NP, one of the important biomarkers for bone turnover, is commonly used for the prediction of bone fracture and the prognosis of osteoporosis after therapy. We developed a P1NP chemiluminescence assay and evaluated changes in bone metabolism markers in lung transplant patients. The screened 2 P1NP antibodies with constructed antigens and α-1 chain antigens expressed by the Corynebacterium glutamate expression system were applied into assay development. The assay performance was evaluated to examine the reliability. A normal Q-Q plot was used to establish male reference interval. Changes of bone metabolism markers before and after lung transplantation in 19 patients were evaluated. The linear factor R of P1NP reagent was greater than 0.99. The limit of detection was 3.32 ng/ml. The precision of the three batches of P1NP reagents was lower than 8%. Method comparison with Roche P1NP reagent showed that the correlation coefficient R2 was 0.91. In the monitoring of bone mass in a short time, bone metabolism markers can better indicate the change of bone mass, while the traditional bone mineral density detection is lagging behind the bone metabolism markers. P1NP and β-CrossLap to bone mass change in patients after lung transplantation, and P1NP and β-CrossLap are very good clinical markers for bone mass monitoring.

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BONE PROPERTIES AND BLOOD BONE METABOLISM MARKERS IN RESPONSE TO EXERCISES AND HONEY SUPPLEMENTATION: A CONTEMPORARY REVIEW

Malaysian Journal of Medical Research ◽

10.31674/mjmr.2018.v02i02.010 ◽

2018 ◽

Vol 2 (2) ◽

pp. 68-74

Author(s):

Foong Kiew Ooi

Keyword(s):

Bone Mass ◽

Bone Metabolism ◽

Bone Health ◽

Research Team ◽

Bone Fragility ◽

Nutritional Intake ◽

Health Economy ◽

Bone Metabolism Markers ◽

Bone Properties ◽

Calcium Phosphorus

Osteoporosis is a disease characterised by a loss of bone mass and the structure deterioration of bone tissue, resulting in bone fragility and fractures. This disease imposes major burden on the health economy and being recognised as one of the major public health problems worldwide. To date, many strategies have been developed with the aim of preventing bone loss and increasing bone mass, these include involvement in physical activity programmes and through appropriate nutritional intake. Honey contains mainly carbohydrates, vitamins and minerals such as calcium, phosphorus and magnesium, which are believed to be important for enhancing bone health. This article discusses the findings of several research studies on bone properties and blood bone metabolism markers in response to combined exercises and honey supplementation in animals and humans, which have been carried out by the bone and exercise research team of Universiti Sains Malaysia.

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Bone metabolism markers predict increase in bone mass, height and sitting height during puberty depending on the VDR Fok1 genotype

Clinical Endocrinology ◽

10.1111/j.1365-2265.2006.02516.x ◽

2006 ◽

Vol 64 (6) ◽

pp. 625-631 ◽

Cited By ~ 6

Author(s):

L. Terpstra ◽

D. L. Knol ◽

S. C. Van Coeverden ◽

H. A. Delemarre-van de Waal

Keyword(s):

Bone Mass ◽

Bone Metabolism ◽

Bone Metabolism Markers ◽

Sitting Height

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Rasprostranennost' osteopenicheskogo sindroma i osobennosti kostnogo metabolizma u zdorovykh detey primorskogo kraya

Osteoporosis and Bone Diseases ◽

10.14341/osteo2006311-13 ◽

2006 ◽

Vol 9 (3) ◽

pp. 11-13

Author(s):

T G Vasil'eva ◽

O G Maksimova ◽

E A Kochetkova

Keyword(s):

Bone Mass ◽

Bone Metabolism ◽

Dual Energy ◽

Healthy Children ◽

Mass Peak ◽

Bone Metabolism Markers ◽

X Ray ◽

Bone Mass Peak ◽

Anthropometric Status

We investigated 130 healthy children and adolescences, its dates of dual-energy X-ray absorbtiometry, bone metabolism markers. The formation of bone mass peak, bone's mineralization in healthy children is depending on age, anthropometric status, sex, dietary with uneven activity in the different local of skeleton. The level of bone metabolism markers is depending on period of life, with maximal dates in patient's 12-14 yeas old. The level of osteopenic syndrome in healthy children consist 15,39%.

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Bone Mass and Bone Metabolism Markers during Adolescence: The HELENA Study

Hormone Research in Paediatrics ◽

10.1159/000314965 ◽

2010 ◽

Vol 74 (5) ◽

pp. 339-350 ◽

Cited By ~ 35

Author(s):

L. Gracia-Marco ◽

G. Vicente-Rodríguez ◽

J. Valtueña ◽

J.P. Rey-López ◽

A.E. Díaz Martínez ◽

...

Keyword(s):

Bone Mass ◽

Bone Metabolism ◽

Bone Metabolism Markers ◽

Helena Study

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The benefits of a high-intensity aquatic exercise program (HydrOS) for bone metabolism and bone mass of postmenopausal women

Journal of Bone and Mineral Metabolism ◽

10.1007/s00774-013-0509-y ◽

2013 ◽

Cited By ~ 3

Author(s):

Linda Denise Fernandes Moreira ◽

Fernanda Cerveira A. O. Fronza ◽

Rodrigo Nolasco dos Santos ◽

Patrícia Lins Zach ◽

Ilda S. Kunii ◽

...

Keyword(s):

Bone Mass ◽

Bone Metabolism ◽

Postmenopausal Women ◽

High Intensity ◽

Exercise Program ◽

Aquatic Exercise

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Bone and Mineral Metabolism Phenotypes in MEN1-Related and Sporadic Primary Hyperparathyroidism, before and after Parathyroidectomy

Cells ◽

10.3390/cells10081895 ◽

2021 ◽

Vol 10 (8) ◽

pp. 1895

Author(s):

Francesca Marini ◽

Francesca Giusti ◽

Federica Cioppi ◽

Davide Maraghelli ◽

Tiziana Cavalli ◽

...

Keyword(s):

Primary Hyperparathyroidism ◽

Bone Mass ◽

Bone Metabolism ◽

Mineral Metabolism ◽

Parathyroid Tissue ◽

Young Patients ◽

Surgical Removal ◽

Mineral Density ◽

Bone Mass Loss ◽

Before And After

Primary hyperparathyroidism (PHPT) is the most common endocrinopathy in multiple endocrine neoplasia type 1 (MEN1). Persistent levels of increased parathyroid hormone (PTH) result in a higher incidence of osteopenia and osteoporosis compared to the general population. Surgical removal of hyper-functioning parathyroid tissue is the therapy of choice. This retrospective study evaluated the effect of parathyroidectomy (PTX) on bone metabolism and bone mass in two series of patients with MEN1 PHPT and sporadic PHPT (sPHPT) by comparing bone metabolism-related biochemical markers and bone mineral density (BMD) before and after surgery. Our data confirmed, in a higher number of cases than in previously published studies, the efficacy of PTX, not only to rapidly restore normal levels of PTH and calcium, but also to normalize biochemical parameters of bone resorption and bone formation, and to improve spine and femur bone mass, in both MEN1 PHPT and sPHPT. Evaluation of single-patient BMD changes after surgery indicates an individual variable bone mass improvement in a great majority of MEN1 PHPT patients. In MEN1 patients, PTX is strongly suggested in the presence of increased PTH and hypercalcemia to prevent/reduce the early-onset bone mass loss and grant, in young patients, the achievement of the bone mass peak; routine monitoring of bone metabolism and bone mass should start from adolescence. Therapy with anti-fracture drugs is indicated in MEN1 patients with BMD lower than the age-matched normal values.

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