scholarly journals Revisiting the past − novel insight into intraspecific molecular diversity and phylogeny of widespread Echinogammarus berilloni

2020 ◽  
pp. 46
Author(s):  
Kamil Hupało
Keyword(s):  
Molecular Diversity ◽  
Model Organism ◽  
Genetic Data ◽  
Intraspecific Diversity ◽  
Future Studies ◽  
Genetic Lineages ◽  
The Past ◽  
High Level ◽  
Taxonomic Studies ◽  
Insight Into

Echinogammarus berilloni (Catta, 1878) is a widespread and euryecious species, inhabiting large parts of Southwestern Europe. Additionally, it is recognized as one of the non-native and invasive species, increasing its range to Central Europe. Even though it is widely used as a model organism in a variety of ecological and ecotoxicological studies, its intraspecific molecular diversity has been overlooked. In this study, the publicly available genetic data reveal high level of intraspecific diversity, supporting presence of up to four phylogenetically distinct genetic lineages. Furthermore, the results indicate that the taxon is not monophyletic. The importance of considering its intraspecific diversity is discussed, highlighting the potential implications for future studies as well as the need for further detailed taxonomic studies.

The water flea Daphnia pulex (Cladocera, Daphniidae), a possible model organism to evaluate aspects of freshwater ecosystems

Crustaceana ◽  
2019 ◽  
Vol 92 (11-12) ◽  
pp. 1415-1426
Author(s):  
Juan-Alejandro Norambuena ◽  
Jorge Farías ◽  
Patricio De los Ríos
Keyword(s):  
Phylogenetic Trees ◽  
Daphnia Pulex ◽  
Model Organism ◽  
Freshwater Ecosystems ◽  
Intraspecific Diversity ◽  
Molecular Tools ◽  
Water Flea ◽  
Future Studies ◽  
Molecular Studies

Abstract Daphnia pulex is a freshwater planktonic crustacean, allegedly a cosmopolitan species, which is found in lentic ecosystems. The aim of this study was to conduct a literature review of D. pulex related to its life history and genetic variability, in order to mark a route for future studies. We noted that D. pulex is a model species on which ecological studies have been carried out, as well as molecular studies, in which its molecular diversity has been characterized and such in specimens from different environments: both pristine and under human influence. In particular those studies are highlighted, in which molecular tools have been used to construct phylogenetic trees for study intraspecific differences. Also, in some of these molecular studies, analyses of genetic, inter- and intraspecific diversity have been performed. In addition, analyses of protein expression in D. pulex and related species seem promising in evaluating the detailed role of this species.

scholarly journals Trends of Acupuncture Therapy on Depression From 2011 to 2020: A Bibliometric Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Hongchun Xiang ◽  
Jing Li ◽  
Bocun Li ◽  
Qian Tan ◽  
Guowei Cai
Keyword(s):  
Acupuncture Therapy ◽  
Behavioral Therapy ◽  
Current Status ◽  
Future Studies ◽  
Republic Of China ◽  
The Past ◽  
Status And Trends ◽  
Insight Into ◽  
Analyze Data

Objectives: The purpose of this study was to explore the current status and trends of acupuncture for depression in the last decade and provide new insights for researchers in future studies.Methods: The articles regarding acupuncture treatment for depression published between 2011 and 2020 were extracted from the Web of Science Core Collection. We used CiteSpace to analyze data on publications, countries, institutions, cited journals, cited authors, cited references, keywords, and citation bursts about acupuncture and depression.Results: A total of 1,032 publications were obtained from 2011 to 2020. We identified the most prolific journals, countries, institutions, and authors in the field of acupuncture for depression in the last decade. The most prolific country and institutions were the People's Republic of China and KyungHee University, respectively. Evidence-based Complementary and Alternative Medicine was the most prolific and cited journal. The author with the highest centrality was Zhangjin Zhang, and the author with the most publications was Park Hi-Joon. The keyword “cognitive behavioral therapy” was first for research developments with the highest citation burst. The five hot topics in acupuncture on depression were “acupuncture,” “depression,” “electro-acupuncture,” “quality of life,” and “anxiety.”Conclusions: The results from this bibliometric study provide insight into the research trends in acupuncture therapy for depression, and the current status and trends of the past decade, which may help researchers determine the current status, hotspots, and frontier trends in this field.

scholarly journals INTERNATIONAL COOPERATION AND RESPONSIBILITY-SHARING TO PROTECT REFUGEES: WHAT, WHY AND HOW?

2017 ◽  
Vol 66 (4) ◽  
pp. 863-892 ◽  
Author(s):  
Rebecca Dowd ◽  
Jane McAdam
Keyword(s):  
New York ◽  
International Cooperation ◽  
Environmental Law ◽  
Host Countries ◽  
The Past ◽  
Refugee Law ◽  
Legal Obligations ◽  
International Refugee Law ◽  
High Level ◽  
Insight Into

AbstractWhile countries that receive refugees have certain legal obligations to assist and protect them, the legal duties of other States to step in and help relieve this burden is less clear. Despite multiple proposals, a mechanism to systematically, equitably and predictably allocate responsibilities between States at a global level has still not been agreed. The UN's High-Level Summit on Addressing Large Movements of Refugees on 19 September 2016 held some promise in this regard, but the resulting New York Declaration was more muted than earlier drafts. This article seeks to provide a unique insight into the meaning of responsibility-sharing and international cooperation from the perspective of individual States. It does so by examining statements they have made at various UN fora over the past decade. It focuses on the two main methods of sharing responsibilities, namely the provision of financial and other assistance to host countries, and the admission of refugees. It then considers the extent to which States perceive responsibility-sharing to be a legal obligation, as opposed to a voluntary undertaking, and analyses this in light of expert opinion. Finally, it discusses the principle of common but differentiated responsibilities, a concept drawn from international environmental law, and considers whether and how it might apply in the international refugee law context.

scholarly journals Mycobacterium avium in the Postgenomic Era

2007 ◽  
Vol 20 (2) ◽  
pp. 205-229 ◽  
Author(s):  
Christine Y. Turenne ◽  
Richard Wallace ◽  
Marcel A. Behr
Keyword(s):  
Mycobacterium Avium ◽  
Status Quo ◽  
Future Studies ◽  
The Past ◽  
The Status ◽  
Functional Understanding ◽  
Similarities And Differences ◽  
Survival Mechanisms ◽  
Insight Into

SUMMARY The past several years have witnessed an upsurge of genomic data pertaining to the Mycobacterium avium complex (MAC). Despite clear advances, problems with the detection of MAC persist, spanning the tests that can be used, samples required for their validation, and the use of appropriate nomenclature. Additionally, the amount of genomic variability documented to date greatly outstrips the functional understanding of epidemiologically different subsets of the organism. In this review, we discuss how postgenomic insights into the MAC have helped to clarify the relationships between MAC organisms, highlighting the distinction between environmental and pathogenic subsets of M. avium. We discuss the availability of various genetic targets for accurate classification of organisms and how these results provide a framework for future studies of MAC variability. The results of postgenomic M. avium study provide optimism that a functional understanding of these organisms will soon emerge, with genomically defined subsets that are epidemiologically distinct and possess different survival mechanisms for their various niches. Although the status quo has largely been to study different M. avium subsets in isolation, it is expected that attention to the similarities and differences between M. avium organisms will provide greater insight into their fundamental differences, including their propensity to cause disease.

scholarly journals Zebrafish as a Model for the Study of Human Myeloid Malignancies

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Jeng-Wei Lu ◽  
Meng-Shan Hsieh ◽  
Heng-An Liao ◽  
Yi-Ju Yang ◽  
Yi-Jung Ho ◽  
...  
Keyword(s):  
Biomedical Research ◽  
Model Organism ◽  
Myeloid Malignancies ◽  
The Past ◽  
Myeloid Progenitor ◽  
Small Molecule Drugs ◽  
Myeloid Progenitor Cells ◽  
Xenograft Models ◽  
Insight Into ◽  
Gene Alterations

Myeloid malignancies are heterogeneous disorders characterized by uncontrolled proliferation or/and blockage of differentiation of myeloid progenitor cells. Although a substantial number of gene alterations have been identified, the mechanism by which these abnormalities interact has yet to be elucidated. Over the past decades, zebrafish have become an important model organism, especially in biomedical research. Several zebrafish models have been developed to recapitulate the characteristics of specific myeloid malignancies that provide novel insight into the pathogenesis of these diseases and allow the evaluation of novel small molecule drugs. This report will focus on illustrative examples of applications of zebrafish models, including transgenesis, zebrafish xenograft models, and cell transplantation approaches, to the study of human myeloid malignancies.

Recovery boiler sootblowers: History and technological advances

TAPPI Journal ◽  
2015 ◽  
Vol 14 (1) ◽  
pp. 51-60
Author(s):  
HONGHI TRAN ◽  
DANNY TANDRA
Keyword(s):  
Cfd Modeling ◽  
Computing Systems ◽  
The Past ◽  
Technological Advances ◽  
Recovery Boilers ◽  
Computational Fluid Dynamics Cfd ◽  
Recovery Boiler ◽  
Steam Parameters ◽  
Insight Into ◽  
Deposit Removal

Sootblowing technology used in recovery boilers originated from that used in coal-fired boilers. It started with manual cleaning with hand lancing and hand blowing, and evolved slowly into online sootblowing using retractable sootblowers. Since 1991, intensive research and development has focused on sootblowing jet fundamentals and deposit removal in recovery boilers. The results have provided much insight into sootblower jet hydrodynamics, how a sootblower jet interacts with tubes and deposits, and factors influencing its deposit removal efficiency, and have led to two important innovations: fully-expanded sootblower nozzles that are used in virtually all recovery boilers today, and the low pressure sootblowing technology that has been implemented in several new recovery boilers. The availability of powerful computing systems, superfast microprocessors and data acquisition systems, and versatile computational fluid dynamics (CFD) modeling capability in the past two decades has also contributed greatly to the advancement of sootblowing technology. High quality infrared inspection cameras have enabled mills to inspect the deposit buildup conditions in the boiler during operation, and helped identify problems with sootblower lance swinging and superheater platens and boiler bank tube vibrations. As the recovery boiler firing capacity and steam parameters have increased markedly in recent years, sootblowers have become larger and longer, and this can present a challenge in terms of both sootblower design and operation.

Upcoming Drifts In Bio-Similars

2020 ◽  
Vol 15 ◽  
Author(s):  
Geeta Aggarwal ◽  
Manju Nagpal ◽  
Ameya Sharma ◽  
Vivek Puri ◽  
Gitika Arora Dhingra
Keyword(s):  
Metabolic Diseases ◽  
Market Competition ◽  
Current Status ◽  
Medicinal Products ◽  
The Past ◽  
Biologic Activity ◽  
Emerging Trends ◽  
Regulatory Guidelines ◽  
Food Drug Administration ◽  
Insight Into

Background: Biopharmaceuticals such as Biologic medicinal products have been in clinical use over the past three decades and have benefited towards the therapy of degenerative and critical metabolic diseases. It is forecasted that market of biologics will be going to increase at a rate of 20% per year, and by 2025, more than ˃ 50% of new drug approvals may be biological products. The increasing utilization of the biologics necessitates for cost control, especially for innovators products that have enjoyed a lengthy period of exclusive use. As the first wave of biopharmaceuticals is expired or set to expire, it has led to various opportunities for the expansion of bio-similars i.e. copied versions of original biologics with same biologic activity. Development of biosimilars is expected to promote market competition, meet worldwide demand, sustain the healthcare systems and maintain the incentives for innovation. Methods: Appraisal of published articles from peer reviewed journals, PubMed literature, latest news and guidelines from European Medicine Agency, US Food Drug Administration (FDA) and India are used to identify data for review. Results: Main insight into the quality requirements concerning biologics, current status of regulation of biosimilars and upcoming challenges lying ahead for the upgrading of marketing authorization of bio-similars has been incorporated. Compiled literature on therapeutic status, regulatory guidelines and the emerging trends and opportunities of biosimilars has been thoroughly stated. Conclusion: Updates on biosimilars will support to investigate the possible impact of bio-similars on healthcare market.

scholarly journals Urban Form Resilience: A Comparative Analysis of Traditional, Semi-Planned, and Planned Neighborhoods in Shiraz, Iran

Urban Science ◽  
2021 ◽  
Vol 5 (1) ◽  
pp. 18
Author(s):  
Ayyoob Sharifi ◽  
Maryam Roosta ◽  
Masoud Javadpoor
Keyword(s):  
Urban Form ◽  
Green Spaces ◽  
Economic Factors ◽  
Urban Resilience ◽  
Future Studies ◽  
Street Networks ◽  
The Past ◽  
Extreme Heat Events ◽  
Physical Form ◽  
Heat Events

As cities are exposed to a portfolio of risks, the concept of resilience has risen to prominence over the past two decades. Consequently, a large volume of research has been published on different aspects of urban resilience. However, urban form resilience is still relatively understudied. As a step toward filling this gap, this study examines resilience of nine selected neighborhoods from Shiraz, an old Iranian city. The selected cases represent three different urban form patterns, namely, traditional, semi-planned, and planned. Different indicators related to the physical configuration of lots, blocks, open and green spaces, and street networks are used to examine resilience of each neighborhood to three major stressors, namely, earthquakes, extreme heat events, and floods. Additionally, a combination of Shannon entropy and the VIKOR (VlseKriterijumska Optimizcija I Kaompromisno Resenje in Serbian) method is used to rank the resilience of each neighborhood to each of the three stressors. Results show that, overall, the physical form of the planned neighborhoods is more conducive to urban resilience. In contrast, the urban form of traditional neighborhoods was found to be less resilient. There were, however, some variations depending on the type of stressor considered. The paper concludes by emphasizing the need to consider social and economic factors in future studies of urban form resilience.

Machine learning for rediscovering revolutionary ideas of the past

2021 ◽  
pp. 105971232098304
Author(s):  
R Alexander Bentley ◽  
Joshua Borycz ◽  
Simon Carrignon ◽  
Damian J Ruck ◽  
Michael J O’Brien
Keyword(s):  
Language Processing ◽  
Scientific Progress ◽  
Phylogenetic Inference ◽  
The Past ◽  
New Methods ◽  
Inherent Nature ◽  
Social Learning Processes ◽  
High Level ◽  
Scientific Ideas ◽  
Revolutionary Science

The explosion of online knowledge has made knowledge, paradoxically, difficult to find. A web or journal search might retrieve thousands of articles, ranked in a manner that is biased by, for example, popularity or eigenvalue centrality rather than by informed relevance to the complex query. With hundreds of thousands of articles published each year, the dense, tangled thicket of knowledge grows even more entwined. Although natural language processing and new methods of generating knowledge graphs can extract increasingly high-level interpretations from research articles, the results are inevitably biased toward recent, popular, and/or prestigious sources. This is a result of the inherent nature of human social-learning processes. To preserve and even rediscover lost scientific ideas, we employ the theory that scientific progress is punctuated by means of inspired, revolutionary ideas at the origin of new paradigms. Using a brief case example, we suggest how phylogenetic inference might be used to rediscover potentially useful lost discoveries, as a way in which machines could help drive revolutionary science.

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