Upcoming Drifts In Bio-Similars

2020 ◽  
Vol 15 ◽  
Author(s):  
Geeta Aggarwal ◽  
Manju Nagpal ◽  
Ameya Sharma ◽  
Vivek Puri ◽  
Gitika Arora Dhingra
Keyword(s):  
Metabolic Diseases ◽  
Market Competition ◽  
Current Status ◽  
Medicinal Products ◽  
The Past ◽  
Biologic Activity ◽  
Emerging Trends ◽  
Regulatory Guidelines ◽  
Food Drug Administration ◽  
Insight Into

Background: Biopharmaceuticals such as Biologic medicinal products have been in clinical use over the past three decades and have benefited towards the therapy of degenerative and critical metabolic diseases. It is forecasted that market of biologics will be going to increase at a rate of 20% per year, and by 2025, more than ˃ 50% of new drug approvals may be biological products. The increasing utilization of the biologics necessitates for cost control, especially for innovators products that have enjoyed a lengthy period of exclusive use. As the first wave of biopharmaceuticals is expired or set to expire, it has led to various opportunities for the expansion of bio-similars i.e. copied versions of original biologics with same biologic activity. Development of biosimilars is expected to promote market competition, meet worldwide demand, sustain the healthcare systems and maintain the incentives for innovation. Methods: Appraisal of published articles from peer reviewed journals, PubMed literature, latest news and guidelines from European Medicine Agency, US Food Drug Administration (FDA) and India are used to identify data for review. Results: Main insight into the quality requirements concerning biologics, current status of regulation of biosimilars and upcoming challenges lying ahead for the upgrading of marketing authorization of bio-similars has been incorporated. Compiled literature on therapeutic status, regulatory guidelines and the emerging trends and opportunities of biosimilars has been thoroughly stated. Conclusion: Updates on biosimilars will support to investigate the possible impact of bio-similars on healthcare market.

scholarly journals Trends of Acupuncture Therapy on Depression From 2011 to 2020: A Bibliometric Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Hongchun Xiang ◽  
Jing Li ◽  
Bocun Li ◽  
Qian Tan ◽  
Guowei Cai
Keyword(s):  
Acupuncture Therapy ◽  
Behavioral Therapy ◽  
Current Status ◽  
Future Studies ◽  
Republic Of China ◽  
The Past ◽  
Status And Trends ◽  
Insight Into ◽  
Analyze Data

Objectives: The purpose of this study was to explore the current status and trends of acupuncture for depression in the last decade and provide new insights for researchers in future studies.Methods: The articles regarding acupuncture treatment for depression published between 2011 and 2020 were extracted from the Web of Science Core Collection. We used CiteSpace to analyze data on publications, countries, institutions, cited journals, cited authors, cited references, keywords, and citation bursts about acupuncture and depression.Results: A total of 1,032 publications were obtained from 2011 to 2020. We identified the most prolific journals, countries, institutions, and authors in the field of acupuncture for depression in the last decade. The most prolific country and institutions were the People's Republic of China and KyungHee University, respectively. Evidence-based Complementary and Alternative Medicine was the most prolific and cited journal. The author with the highest centrality was Zhangjin Zhang, and the author with the most publications was Park Hi-Joon. The keyword “cognitive behavioral therapy” was first for research developments with the highest citation burst. The five hot topics in acupuncture on depression were “acupuncture,” “depression,” “electro-acupuncture,” “quality of life,” and “anxiety.”Conclusions: The results from this bibliometric study provide insight into the research trends in acupuncture therapy for depression, and the current status and trends of the past decade, which may help researchers determine the current status, hotspots, and frontier trends in this field.

scholarly journals Systems Thinking: A Review and Bibliometric Analysis

Systems ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 23 ◽  
Author(s):  
Niamat Ullah Ibne Hossain ◽  
Vidanelage L. Dayarathna ◽  
Morteza Nagahi ◽  
Raed Jaradat
Keyword(s):  
Network Analysis ◽  
Systems Thinking ◽  
Future Research ◽  
Rank Analysis ◽  
Academic Literature ◽  
The Past ◽  
Research Areas ◽  
Emerging Trends ◽  
Insight Into ◽  
Leading Journals

Systems thinking (ST) is an interdisciplinary domain that offers different ways to better understand the behavior and structure of a complex system. Over the past decades, several publications can be identified in academic literature, focusing on different aspects of systems thinking. However, two critical questions are not properly addressed in the extant body of ST literature: (i) How to conduct the content analysis exclusively to derive the prominent statistics (i.e., influential journals, authors, affiliated organizations and countries) pertaining to the domain of ST? (ii) How to get better insights regarding the current and emerging trends that may evolve over time based on the existing body of ST literature? To address these gaps, the aim of this research study is to provide a comprehensive insight into the domain of systems thinking through bibliometric and network analysis. Beginning with over 6000 accumulated publications, the analysis narrowed down to 626 prominent articles with proven influence published over the past three decades. Leveraging rigorous bibliometric tools analysis, this research unveils the influential authors, leading journals and top contributing organizations and countries germane to the domain of systems thinking. In addition, citation, co-citation and page rank analysis used to rank top influential articles in the area of systems thinking. Finally, with the aid of the network analysis, key clusters in the existing literature are identified based on the research areas of systems thinking. The findings of this research will serve as a bluebook for practitioners and scholars to conduct future research within systems thinking context.

scholarly journals Overcoming methodological issues in measuring financial literacy of companies, a proposed measurement model

2020 ◽  
Author(s):  
Éva Kuruczleki
Keyword(s):  
Financial Literacy ◽  
Measurement Model ◽  
Measurement Methods ◽  
Firm Level ◽  
Financial Decisions ◽  
The Past ◽  
Emerging Trends ◽  
Complex Models ◽  
The Individual ◽  
Insight Into

In the past decade, individual and company financial literacy measurement methods went through substantial changes. To investigate factors contributing to financial literacy of both individuals and firms, scholars needed to reach out for new measurement methods other than the traditional knowledge tests widely used previously. This paper provides a synthesis of the most recent studies concerning both individual and company financial literacy regarding the dimensions of financial literacy and methods available for measuring and modelling financial literacy. The results highlight new emerging trends in the assessment: qualitative methods (e. g. interviews and case studies), for getting insight into very special segments of financial literacy, and more elaborate and complex models, such as OLS regression, bivariate and multivariate logit and probit models, which provide effective ways to get a deeper understanding of the interaction of factors forming and determining financial literacy both at the individual at company level. However, even though the toolkit of measuring financial literacy is getting richer and richer, the connection between the individual and firm-level models seem to be nonexistent. This paper proposes a measurement model with the help of which company financial literacy can be measured through the assessment of individuals and their relationship contributing to firm-level financial decisions.

scholarly journals Emerging nanotechnologies for cancer immunotherapy

2016 ◽  
Vol 241 (10) ◽  
pp. 1116-1126 ◽  
Author(s):  
Sourabh Shukla ◽  
Nicole F Steinmetz
Keyword(s):  
Cancer Vaccines ◽  
Checkpoint Inhibitors ◽  
Clinical Success ◽  
Current Status ◽  
Emerging Trends ◽  
Frequent Administration ◽  
Challenges And Opportunities ◽  
Cancer Immunotherapies ◽  
Insight Into

Founded on the growing insight into the complex cancer-immune system interactions, adjuvant immunotherapies are rapidly emerging and being adapted for the treatment of various human malignancies. Immune checkpoint inhibitors, for example, have already shown clinical success. Nevertheless, many approaches are not optimized, require frequent administration, are associated with systemic toxicities and only show modest efficacy as monotherapies. Nanotechnology can potentially enhance the efficacy of such immunotherapies by improving the delivery, retention and release of immunostimulatory agents and biologicals in targeted cell populations and tissues. This review presents the current status and emerging trends in such nanotechnology-based cancer immunotherapies including the role of nanoparticles as carriers of immunomodulators, nanoparticles-based cancer vaccines, and depots for sustained immunostimulation. Also highlighted are key translational challenges and opportunities in this rapidly growing field.

scholarly journals Making Medicines Baby Size: The Challenges in Bridging the Formulation Gap in Neonatal Medicine

2019 ◽  
Vol 20 (11) ◽  
pp. 2688 ◽  
Author(s):  
Fiona O’Brien ◽  
David Clapham ◽  
Kamelia Krysiak ◽  
Hannah Batchelor ◽  
Peter Field ◽  
...  
Keyword(s):  
Medication Errors ◽  
Dosage Forms ◽  
Medicinal Products ◽  
Term Neonates ◽  
Routes Of Administration ◽  
The Past ◽  
Age Appropriate ◽  
Insight Into ◽  
Regulatory Challenges

The development of age-appropriate formulations should focus on dosage forms that can deliver variable yet accurate doses that are safe and acceptable to the child, are matched to his/her development and ability, and avoid medication errors. However, in the past decade, the medication needs of neonates have largely been neglected. The aim of this review is to expand on what differentiates the needs of preterm and term neonates from those of the older paediatric subsets, in terms of environment of care, ability to measure and administer the dose (from the perspective of the patient and carer, the routes of administration, the device and the product), neonatal biopharmaceutics and regulatory challenges. This review offers insight into those challenges posed by the formulation of medicinal products for neonatal patients in order to support the development of clinically relevant products.

Advances In Asthma Care

2003 ◽  
Vol 1 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Chris Garvey
Keyword(s):  
Healthcare Costs ◽  
Professional Organizations ◽  
Current Status ◽  
Asthma Care ◽  
Advanced Level ◽  
Clinical Criteria ◽  
Asthma Knowledge ◽  
The Past ◽  
The Us ◽  
Examination Process

Asthma rates in the US have risen during the past 25 years, as have asthma-related morbidity and healthcare costs. Professional organizations involved in asthma care have identified the need to assure that an advanced level of asthma knowledge and skill is available to patients with asthma, their families, and insurers. This need led to development of the certification for asthma educators. The Certified Asthma Educator (AE-C) must meet specific clinical criteria and pass a standardized examination designed to evaluate knowledge and skill for providing competent asthma education and coordination. The development and current status of the Certified Asthma Educator examination process and content are discussed, as are goals of the certification

Recovery boiler sootblowers: History and technological advances

TAPPI Journal ◽  
2015 ◽  
Vol 14 (1) ◽  
pp. 51-60
Author(s):  
HONGHI TRAN ◽  
DANNY TANDRA
Keyword(s):  
Cfd Modeling ◽  
Computing Systems ◽  
The Past ◽  
Technological Advances ◽  
Recovery Boilers ◽  
Computational Fluid Dynamics Cfd ◽  
Recovery Boiler ◽  
Steam Parameters ◽  
Insight Into ◽  
Deposit Removal

Sootblowing technology used in recovery boilers originated from that used in coal-fired boilers. It started with manual cleaning with hand lancing and hand blowing, and evolved slowly into online sootblowing using retractable sootblowers. Since 1991, intensive research and development has focused on sootblowing jet fundamentals and deposit removal in recovery boilers. The results have provided much insight into sootblower jet hydrodynamics, how a sootblower jet interacts with tubes and deposits, and factors influencing its deposit removal efficiency, and have led to two important innovations: fully-expanded sootblower nozzles that are used in virtually all recovery boilers today, and the low pressure sootblowing technology that has been implemented in several new recovery boilers. The availability of powerful computing systems, superfast microprocessors and data acquisition systems, and versatile computational fluid dynamics (CFD) modeling capability in the past two decades has also contributed greatly to the advancement of sootblowing technology. High quality infrared inspection cameras have enabled mills to inspect the deposit buildup conditions in the boiler during operation, and helped identify problems with sootblower lance swinging and superheater platens and boiler bank tube vibrations. As the recovery boiler firing capacity and steam parameters have increased markedly in recent years, sootblowers have become larger and longer, and this can present a challenge in terms of both sootblower design and operation.

Water resources management in Greece: current status and prospective outlook

1995 ◽  
Vol 32 (9-10) ◽  
pp. 267-272 ◽  
Author(s):  
A. Angelakis ◽  
E. Diamadopoulos
Keyword(s):  
Water Resources ◽  
Water Resources Management ◽  
Water Demand ◽  
Treatment Plant ◽  
Current Status ◽  
Reclaimed Wastewater ◽  
Resources Management ◽  
The Past ◽  
Precipitation Water ◽  
Pollution Loads

The basic aim of this paper is to present the existing conditions and problems of water resources management in Greece. Water demand has increased tremendously over the past 30 years. Despite adequate precipitation, water imbalance is often experienced, due to temporal and regional variations of the precipitation, the increased water demand during the summer months and the difficulty of transporting water due to the mountainous terrain. Integration of reclaimed wastewater originating from the wastewater treatment plant effluents into the water resources management is proposed. This plan exhibits the potential for reducing the pollution loads entering sea or inland waters, while at the same time providing water for irrigation.

Pharmacological Targeting of Neuronal Kv7.2/3 Channels: A Focus on Chemotypes and Receptor Sites

2018 ◽  
Vol 25 (23) ◽  
pp. 2637-2660 ◽  
Author(s):  
Francesco Miceli ◽  
Maria V. Soldovieri ◽  
Paolo Ambrosino ◽  
Laura Manocchio ◽  
Ilaria Mosca ◽  
...  
Keyword(s):  
Metabolic Diseases ◽  
Scientific Literature ◽  
New Drugs ◽  
Current Status ◽  
Functional Heterogeneity ◽  
Molecular Scaffolds ◽  
Kv7 Channels ◽  
Receptor Sites ◽  
Pharmacological Targets ◽  
Pharmacological Potential

Background: The Kv7 (KCNQ) subfamily of voltage-gated potassium channels consists of 5 members (Kv7.1-5) each showing characteristic tissue distribution and physiological roles. Given their functional heterogeneity, Kv7 channels represent important pharmacological targets for the development of new drugs for neuronal, cardiovascular and metabolic diseases. <p> Objective: In the present manuscript, we focus on describing the pharmacological relevance and potential therapeutic applications of drugs acting on neuronally-expressed Kv7.2/3 channels, placing particular emphasis on the different chemotypes, and highlighting their pharmacodynamic and, whenever possible, pharmacokinetic peculiarities. <p> Methods: The present work is based on an in-depth search of the currently available scientific literature, and on our own experience and knowledge in the field of neuronal Kv7 channel pharmacology. Space limitations impeded to describe the full pharmacological potential of Kv7 channels; thus, we have chosen to focus on neuronal channels composed of Kv7.2 and Kv7.3 subunits, and to mainly concentrate on their involvement in epilepsy. <p> Results: An astonishing heterogeneity in the molecular scaffolds exploitable to develop Kv7.2/3 modulators is evident, with important structural/functional peculiarities of distinct compound classes. <p> Conclusion: In the present work we have attempted to show the current status and growing potential of the Kv7 pharmacology field. We anticipate a bright future for the field, and express our hopes that the efforts herein reviewed will result in an improved treatment of hyperexcitability (or any other) diseases.

Antibacterial and Anti-Biofilm Biosynthesised Silver and Gold Nanoparticles for Medical Applications: Mechanism of Action, Toxicity and Current Status

2020 ◽  
Vol 17 (2) ◽  
pp. 88-100 ◽  
Author(s):  
Sundos Suleman Ismail Abdalla ◽  
Haliza Katas ◽  
Fazren Azmi ◽  
Mohd Fauzi Mh Busra
Keyword(s):  
Gold Nanoparticles ◽  
Synthesis Method ◽  
Chemical Characterization ◽  
Current Status ◽  
Silver And Gold Nanoparticles ◽  
Physical And Chemical Characterization ◽  
Biosynthesized Agnps ◽  
Physical And Chemical ◽  
Insight Into ◽  
Bio Synthesis

Fast progress in nanoscience and nanotechnology has contributed to the way in which people diagnose, combat, and overcome various diseases differently from the conventional methods. Metal nanoparticles, mainly silver and gold nanoparticles (AgNPs and AuNPs, respectively), are currently developed for many applications in the medical and pharmaceutical area including as antibacterial, antibiofilm as well as anti-leshmanial agents, drug delivery systems, diagnostics tools, as well as being included in personal care products and cosmetics. In this review, the preparation of AgNPs and AuNPs using different methods is discussed, particularly the green or bio- synthesis method as well as common methods used for their physical and chemical characterization. In addition, the mechanisms of the antimicrobial and anti-biofilm activity of AgNPs and AuNPs are discussed, along with the toxicity of both nanoparticles. The review will provide insight into the potential of biosynthesized AgNPs and AuNPs as antimicrobial nanomaterial agents for future use.

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