scholarly journals Application du plasma atmosphérique froid en oncologie : une revue systématique

2020 ◽  
Author(s):  
A. Dubuc ◽  
P. Monsarrat ◽  
S. Laurencin-Dalicieux ◽  
F. Virard ◽  
J.P. Sarrette ◽  
...  
Keyword(s):  
Google Scholar ◽  
Essais Cliniques ◽  
Revue Systématique ◽  
Espèces Réactives De L’Oxygène

Introduction : Le plasma atmosphérique froid est un gaz ionisé produit à pression atmosphérique. Plusieurs applications médicales sont étudiées, notamment la cicatrisation des plaies chroniques et l’effet antimicrobien. En effet, le traitement par plasma permet de générer de nombreuses espèces réactives de l’oxygène et de l’azote. L’application d’un tel traitement in-vitro sur des cellules eucaryotes a montré de nombreux effets cellulaires tel que l’apoptose. Les applications dans le domaine de l’oncologie ont par conséquent été étudiées. Objectif : L’objectif de cette revue systématique est d’analyser l’utilisation du plasma atmosphérique froid en oncologie ainsi que les méthodologies (lignées cellulaires ciblées, paramètres physiques, thérapies directes ou indirectes) mises en oeuvre jusqu’à ce jour. Matériels et méthodes : Les bases de données Pubmed, ICTRP et Google Scholar ont été explorées jusqu’au 17/01/2017 afin de recenser les études traitant de l’utilisation du plasma en oncologie, que ce soit des études in-vitro, in-vivo ou des essais cliniques. Résultats : 150 articles originaux ont été inclus. Les Jets de plasma sont les systèmes de production de plasma les plus utilisés (73,3%). L’hélium est le gaz le plus utilisé (34%) suivi par l’air (28%) et l’argon (19,3%). Les études sont principalement in-vitro (94%). L’application directe du plasma est la plus représentée (84,2%). Les lignées cellulaires ciblées sont la plupart dérivées de lignées cancéreuses humaines (82%), en particulier des lignées issues de cancer du cerveau (16,6%). Conclusions : Cette étude met en évidence la multiplicité de moyens de production et d’applications clinques du plasma atmosphérique froid en oncologie. Alors que certains dispositifs peuvent être utilisés directement sur les patients, d’autres ouvrent la voie au développement de nouveaux produits pharmaceutiques qui pourraient être produits à échelle industrielle. L’utilisation clinique du plasma nécessite la mise au point de protocoles fiables et standardisés afin de déterminer le plasma le plus adapté à chaque type de cancers et d’envisager son association avec les traitements conventionnels.

scholarly journals EFFECT OF Mucuna pruriens ON SPERM PARAMETERS WITH IDIOPATHIC INFERTILITY: A SYSTEMATIC REVIEW

2021 ◽  
Vol p5 (03) ◽  
pp. 2802-2810
Author(s):  
Deepthika S. H. K ◽  
Karunagoda K. P. K. R
Keyword(s):  
Systematic Review ◽  
Sperm Count ◽  
Sperm Parameters ◽  
Google Scholar ◽  
Mucuna Pruriens ◽  
Cochrane Library ◽  
Idiopathic Infertility ◽  
Vitro Effect

In Ayurveda Mucuna pruriens (M. pruriens) is considered as a medicine for male subfertility. There are in vitro, in vivo and literature reviews to demonstrate beneficial medicinal effects of M. pruriens in worldwide. This study aims to systematically review the scientific literature and provide a comprehensive summary on the effect of M. pruriens on sperm parameters with idiopathic infertility. A comprehensive systematic review was conducted in the following databases: PubMed, Google scholar and Cochrane library for research articles published in between 2000 and 2020. The keywords that were used in combination to search for articles included, "Mucuna pruriens","idio- pathic infertility" and "sperm parameters". The literature search done by using keywords and identified following number of articles in the respective databases; PubMed (n=13), Google scholar (n= 116), and Cochrane library (n=4). After removing duplications, the total number of articles included in the present review is 124. 114 studies were omitted due to exclusion criteria and use of combine M. pruriens with other medicinal herbs, due to the im- possibility of determining the net effect of M. pruriens. Included articles were screened in the final stage by reading the full article. There were 10 different studies evaluating the in vitro effect of M. pruriens on sperm parameters with idiopathic infertility. The results of this study showed that consumption of M. pruriens significantly improves sperm count and motility. According to studies (n=2) M. pruriens can improve morphological defects of sperms to some extents and none of those studies recorded any adverse effects. Keywords: Mucuna pruriens, Sperm parameters, Idiopathic infertility, Motility, Morphology

scholarly journals Plantas brasileiras com ação anticolinesterásica – uma revisão

2022 ◽  
Vol 11 (1) ◽  
pp. e6211124262
Author(s):  
Francisco Flávio da Silva Lopes ◽  
Lucas Soares Frota ◽  
Gilson Araújo Fontenele ◽  
Marcus Vinícius Ferreira da Silva ◽  
Victor Borges Fernandes ◽  
...  
Keyword(s):  
Web Of Science ◽  
Google Scholar

O Brasil possui uma grande flora distribuída por todo seu território, contendo a maior diversidade genética em espécies do mundo, muitas delas utilizadas para fins terapêutico. As plantas são as melhores fontes para a descoberta de compostos bioativos contra as doenças. A Doença de Alzheimer é uma doença neurodegenerativa caracterizada pela perda de memória, afeta principalmente a população com mais de 65 anos de idade. Este trabalho descreve um levantamento sobre extratos e óleos obtidos a partir de plantas da flora brasileira com potencial ação anticolinesterásica. Realizou-se uma revisão bibliográfica sistemática da produção científica em bases de dados da CAPES, Google Scholar, PubMed, Scielo, Science Direct, SciFinder, Scopus e Web of Science. Selecionou-se 41 artigos publicados entre 2011 e 2021. Foram identificadas 152 espécies vegetais distribuídas em 49 famílias botânicas, onde a Fabaceae foi a mais citada com 32 espécies (21,05%). A produção de extrato foi a principal forma escolhida, 253 vezes (93,36%). As folhas foram as partes mais utilizada, 94 vezes (43,12%). As extrações por etanol se destacaram com 140 vezes (51,66%). A maioria dos ensaios avaliou a inibição da acetilcolinesterase em microplaca de 96 poços, 182 ensaios (54,17%). De todas as espécies relatadas 110 promoveram a inibição, desse total 66,36% obtiveram uma alta intensidade. O estudo atingiu seu objetivo ao mostrar resultados relevantes na inibição da AChE, porém vale ressaltar que diante do tamanho da nossa flora, poucas espécies foram investigadas, tampouco foram testadas in vivo para se corroborar com os resultados dos ensaios in vitro.

Reseaches to Study the Improvement Solubility of Curcumin in the Development of a Dosage form with Methionine and Turmeric Extract (Curcuma Longa)

2021 ◽  
Vol 18 (1) ◽  
pp. 43-51
Author(s):  
A.A. Khisamova ◽  
Keyword(s):  
Water Solubility ◽  
Web Of Science ◽  
Raw Materials ◽  
Curcuma Longa ◽  
Solid Dispersions ◽  
Google Scholar ◽  
Plant Raw Materials ◽  
Effective Delivery

Introduction. Turmeric (Curcuma longa) is a medicinal plant and seasoning in Asia. Curcumin (diferuloylmethane) is the main active ingredient; a hydrophobic bioactive component contains in the rhizomes of turmeric (Curcuma longa). In recent years, curcumin has attracted tremendous attention not only for its use in cooking, but also for pleiotropic biological and pharmacological effects. However, its poor water solubility, low bioavailability and rapid metabolism are serious disadvantages for implementation in therapeutic practice. Therefore, researchers are attempting to increase the biological and pharmacological activity of curcumin using effective delivery systems and the addition of bioenhancers. Aim. Generalization and analysis of data presented in the databases PubMed, Web of science, Scopus, Google Scholar on methods of increasing the solubility and bioavailability of curcumin in the development of pharmaceutical compositions based on it. Materials and methods. Materials and methods. The object of research and search in the PubMed, Web of science, Scopus, Google Scholar databases was the substance curcumin, obtained from plant raw materials of long turmeric (Curcuma longa). We analyzed the data presented in the open press for the last 20 years (2000-2021), the request included indicators of the solubility and bioavailability of curcumin in vitro and in vivo. Conclusion. Various pharmaceutical studies of the use of oral combinations, including solid dispersions, nano/microparticles, polymer micelles, nanosuspensions, lipid-based nanocarriers, cyclodextrins, conjugates, have been developed to improve the oral bioavailability of curcumin. They have been shown to increase the solubility of curcumin, improve intestinal stability, and alter the absorption pathway.

Bioaccesibilidad de antioxidantes de origen vegetal micro y nanoencapsulados: perspectivas para su determinacion in vitro

2019 ◽  
Vol 12 (11) ◽  
Author(s):  
A. Hernández-Jabalera ◽  
M. Mena-Martínez ◽  
E. León-Espinosa ◽  
A.A. Rayas-Amor ◽  
M. Díaz-Ramírez ◽  
...  
Keyword(s):  
Google Scholar

Objetivo: Discutir las perspectivas utilizadas para la evaluación in vitro de la bioaccesibilidad de antioxidantes vegetales para identificar el alcance y las limitaciones de la micro y nanoencapsulación y los modelos de digestión. Diseño/metodología/aproximación: Discusión analítica de la información obtenida de SCOPUS, EBSCO, ScienceDirect, google scholar con los términos antioxidante, micro/ nanoencapsulación, bioaccesibilidad, digestión, liberación. Resultados: Los sistemas de antioxidantes encapsulados evaluados privilegian el uso de extractos frente a moléculas purificadas, el aprovechamiento de subproductos y las tecnologías de amplia distribución. Los modelos estáticos in vitro son los más utilizados, con diferencias en los elementos y etapas de la digestión. El análisis de la experiencia acumulada proporciona evidencia alentadora en términos de resistencia a las condiciones gástricas y una mayor liberación durante la fase intestinal utilizando concentraciones logradas en una cantidad dispersable de micro o nanocapsulas. Limitaciones del estudio/implicaciones: Sistemas nuevos con características prometedoras para los que aún no se han realizado pruebas de simulación de la digestión se encuentran fuera del alcance de esta revisión. Hallazgos/conclusiones: Para trasladar la experiencia recopilada hacia  la bioaccesibilidad real de los antioxidantes se requiere atender a las recomendaciones para la estandarización de los modelos de digestión in vitro de tipo estáticos,  así como considerar las limitaciones derivadas de la pérdida inicial de antioxidantes durante la producción del sistema encapsulado, la poca información proporcionada respecto al tipo de liberación, su acumulación y los posibles efectos tóxicos, la determinación de la representatividad de las concentraciones evaluadas respecto a las necesarias in vivo. 

Aflatoxina M1 e Aflatoxina B1-lisina como Biomarcadores de Avaliação da Eficiência de Adsorventes para Aflatoxinas: Artigo de Revisão

2018 ◽  
Vol 22 (3) ◽  
pp. 171 ◽  
Author(s):  
Roice Eliana Rosim ◽  
Carlos Augusto Fernandes de Oliveira ◽  
Carlos Humberto Corassin
Keyword(s):  
Aflatoxin B1 ◽  
Animal Feed ◽  
Biological Fluids ◽  
Animal Health ◽  
Google Scholar ◽  
Aflatoxin M1 ◽  
Published Data ◽  
The Individual

A contaminação de alimentos por aflatoxinas, principalmente, a aflatoxina B1 (AFB1) representa um problema mundial para a saúde humana e animal. Uma forma de avaliar a exposição a estes contaminantes é analisando a dieta para verificar a ocorrência destes compostos. Esta metodologia, no entanto, tem limitações devido à variabilidade das aflatoxinas encontradas nos alimentos e às diferenças individuais na toxicocinética dos compostos. Por outro lado, o biomonitoramento de aflatoxinas em fluidos biológicos se utilizando de biomarcadores gera informações mais confiáveis sobre a exposição a estas toxinas nos indivíduos. O uso de adsorventes químicos na ração animal possibilita a detoxificação de aflatoxinas sem produzir efeitos tóxicos nem alterar as propriedades nutricionais. Este trabalho teve por objetivo revisar os dados publicados sobre a eficiência in vitro e in vivo de adsorventes para aflatoxinas, bem como estudos referentes ao uso da aflatoxina M1 (AFM1) e da AFB1-lisina como biomarcadores para avaliar a redução da biodisponibilidade da AFB1 por adsorventes em rações. Trabalhos relevantes publicados nos últimos dez anos (2009-presente) foram selecionados nas bases de dados PubMed, Science Direct e Google Scholar. A determinação de AFM1 no leite e/ou na urina, bem como de AFB1-lisina no soro, indica a biodisponibilidade individual da AFB1 em ensaios para avaliar a eficiência de adsorventes em animais. Deste modo, a utilização destes biomarcadores permite reduzir os custos dos ensaios in vivo, além de proporcionar maior padronização dos experimentos e possibilitar a avaliação da eficiência dos adsorventes em condições de campo. Palavras chave: AFB1. - Adsorventes Minerais. Biomarcadores de Exposição - AFB1-lisina - AFM1           AbstractFood contamination by aflatoxins, mainly aflatoxin B1 (AFB1), is a worldwide concern for human and animal health. A possible way to assess the exposure to these contaminants is through the diet analyses to verify the occurrence of mycotoxins. However, this methodology has important limitations due to the variability of mycotoxins found in the food and the individual differences in the toxicokinetics of the compounds. On the other hand, biomonitoring of aflatoxins in biological fluids using biomarkers generates more reliable information on the exposure to these toxins in individuals. The use of chemical adsorbents in animal feed makes it possible to detoxify mycotoxins without producing toxic effects or altering the nutritional properties. The aim of this study was to revise the available published data on the in vitro and in vivo efficacy of adsorbents for aflatoxins, as well as studies on the use of aflatoxin M1 (AFM1) and AFB1-lysine as biomarkers to evaluate the reduction in the bioavailability of AFB1 by adsorbents in feed. Relevant articles published in the last 10 years (2009-present) were selected in PubMed, Science Direct and Google Scholar. Determination of AFM1 in milk and/or urine, and AFB1-lysine in serum, indicate the individual bioavailability of AFB1 in trials conducted for evaluation of adsorbent’s efficiency in animals. Thus, the use of these biomarkers may reduce the costs of in vivo trials, increase the standardization of experiments, and evaluate the adsorbents’ efficiency under field conditions. Keywords: Aflatoxin B1 – Clays - Exposure Biomarkers - Aflatoxin B1-lysine Aflatoxin M1. 

scholarly journals Potensi Daun Kastuba (Euphorbia Pulcherrima) Sebagai Antimalaria Plasmodium Falciparum

2020 ◽  
Vol 18 (1) ◽  
pp. 1
Author(s):  
ELVINA VERONICA ◽  
NI KADEK SINTA DWI CHRISMAYANTI
Keyword(s):  
Plasmodium Falciparum ◽  
Literature Review ◽  
Combination Therapy ◽  
In Silico ◽  
Artemisinin Combination Therapy ◽  
Ornamental Plants ◽  
Google Scholar ◽  
Euphorbia Pulcherrima

<p><strong>Abstract</strong></p><p><strong>Introduction:</strong> Around 41% of people in the world at risk of malaria due to plasmodium infection. <em>Plasmodium falciparum</em> is the most dangerous malaria infection compared to another plasmodium because it causes 90% of malaria deaths. ACT (Artemisinin Combination Therapy) is the goal standard of malaria medicine, is starting to become resistant, so other alternatives are needed. Poinsettia plants (<em>Euphorbia pulcherrima</em>) are ornamental plants and contain compounds that potential as anti-parasites.</p><p><strong>Objective:</strong> To aims the potential of poinsettia leaves as an antimalarial alternative to <em>Plasmodium falciparum</em> in malaria treatment.</p><p><strong>Methods:</strong> Literature studies using in vivo, in vitro, in silico research articles, and literature reviews from national and international journals accessed from Google Scholar, Elsevier, Science Direct, and Pubmed in the last 10 years using malaria, antioxidants, anti-malaria, <em>Plasmodium falciparum</em>, and <em>Euphorbia pulcherrima</em> as keywords. There were 22 relevant articles used in this literature review.</p><p><strong>Results:</strong> Antioxidants in poinsettia leaves inhibited plasmodium growth by inhibit nutrient transport at new permeation pathways and prevent hemozoin ban. Terpenoids in poinsettia inhibit schizont and trophozoite in an earlier asexual phase of <em>Plasmodium falciparum</em> by inhibiting isoprenoid biosynthesis.</p><p><strong>Conclusion:</strong> Poinsettia (<em>Euphorbia pulcherrima</em>) has the potency to be an antimalarial alternative against <em>Plasmodium falciparum</em>. Need further research about the dosage and side effects of the usage.</p><p><strong>Key words:</strong> Malaria, antioxidants, anti-malaria, <em>Plasmodium falciparum</em>, <em>Euphorbia pulcherrima</em></p><p><strong>Abstrak</strong></p><p><strong>Pendahuluan:</strong> Sebesar 41% penduduk di dunia berisiko terkena malaria akibat infeksi plasmodium. Infeksi malaria akibat <em>Plasmodium falciparum</em> merupakan infeksi paling berbahaya dibandingkan plasmodium lainnya karena menyebabkan 90% kematian malaria. obat malaria ACT (<em>Artemisinin Combination Therapy</em>) yang merupakan pengobatan goal standar obat malaria kini mulai resistensi sehingga diperlukan alternatif lainnya. Tanaman kastuba (<em>Euphorbia pulcherrima</em>) merupakan tanaman hias dan memiliki kandungan senyawa antioksidan yang berpotensi sebagai anti parasit.</p><p><strong>Tujuan</strong>: mengetahui potensi daun kastuba sebagai alternatif antimalarial <em>Plasmodium falciparum</em> dalam pengobatan malaria.</p><p>Metode: Studi literatur menggunakan artikel penelitian in vivo, in vitro, in silico, dan artikel tinjauan pustaka dari jurnal nasional dan internasional yang diakses dari Google Scholar, Elsevier, Science Direct, dan Pubmed 10 tahun terakhir menggunakan kata kunci malaria, antioksidan, anti-malaria, <em>Plasmodium falciparum</em>, <em>Euphorbia pulcherrima</em>. Digunakan 22 artikel yang relevan dalam <em>literature review</em> ini.</p><p><strong>Hasil:</strong> Antioksidan tanaman kastuba menghambat perkembangan plasmodium dengan menghambat transport nutrisi jalur permeasi baru dan mencegah pembentukan hemozoin. Terpenoid dalam tanaman kastuba menghambat pembentukan skizon dan tropozoit fase aseksual <em>Plasmodium falciparum</em> dengan menghambat biosintesis isoprenoid.</p><p><strong>Kesimpulan:</strong> Tanaman kastuba (<em>Euphorbia pulcherrima</em>) berpotensi sebagai alternatif antimalarial terhadap <em>Plasmodium falciparum</em>. Perlu penelitian lebih lanjut terutama dalam dosis dan efek samping penggunaannya.</p><p><strong>Kata kunci</strong>: Malaria, antioksidan,<em> anti-malaria, Plasmodium falciparum, Euphorbia pulcherrima </em></p>

scholarly journals EFEKTIFITAS EKSTRAK TANAMAN JARAK PAGAR (JATROPHA CURCAS L.) TERHADAP PENYEMBUHAN LUKA : LITERATUR REVIEW

2020 ◽  
Vol 6 (2) ◽  
pp. 184-191
Author(s):  
Suhirman Suhirman ◽  
Takdir Tahir ◽  
Saldy Yusuf
Keyword(s):  
Wound Healing ◽  
Jatropha Curcas ◽  
Google Scholar ◽  
Jatropha Curcas L ◽  
Mesh Terms

Latar belakang : Kandungan ekstrak tumbuhan telah digunakan sudah sejak lama sebagai salah satu metode alternatif/komplementer terutama dalam penyembuhan luka, hanya saja belum terinci sehingga perlu pengujian baik secara in vitro maupun in vivo. Tujuan : Untuk mengetahui sejauhmana efektifitas tanaman Jatropha Curcas L. terhadap penyembuhan luka dengan pendekatan dari beberapa penelitian yang telah ada sebelumnya. Metode : Metode  dari tinjauan literature ini menggunakan pedoman Prisma  dengan penelusuran artikel ilmiah menggunakan data based Pubmed, Google Scholar dan Science Direct.  Melakukan pencarian pada Pubmed dengan kata kunci Extract Jatropha Curcas L. [MeSH Terms] AND wound healing [MeSH Terms], google Scholar dengan kata kunci Extract Jatropha Curcas L AND wound healing, sedangkan Science Direct dengan kata kunci Ekstrak Jatropha Curcas L. AND wound healing  Hasil : Dari beberapa artikel penelitian yang telah diulas menunjukkan bahwa efektifitas dari ekstrak tanaman jarak pagar (Jatropha Curcas L.) memiliki pengaruh terhadap penyembuhan luka pada hewan coba tikus Wistar.    

scholarly journals Minyak Kayu Putih, Obat Alami dengan Banyak Khasiat: Tinjauan Sistematik

2020 ◽  
Vol 26 (2) ◽  
Author(s):  
Susana Elya Sudradjat
Keyword(s):  
Google Scholar ◽  
Medicinal Properties

Minyak kayu putih adalah salah satu obat tradisional yang digunakan untuk penyakit saluran nafas seperti asma, sinusitis, dan paru-paru. Eucalyptol atau 1,8-sineol merupakan bahan aktif dari minyak kayuputih biasa digunakan untuk mengobati peradangan saluran nafas. Penelitian secara in vitro maupun in vivo menunjukkan bahwa 1,8-sineol memperlihatkan banyak khasiat. Tulisan ini bertujuan untuk mengulas secara sistimatik dan komprehensif dari pustaka tentang kegunaan dari 1,8-sineol sebagai bahan obat untuk berbagai penyakit. Pustaka dikumpulkan melalui Pub Med dan Google Scholar sampai dengan tanggal 27 Mei 2020, dengan kata kunci : 1,8-cineole, eucalyptol, respiratory, medicinal properties. Dari penelusuran literatur didapatkan 116 jurnal dari PubMed dan  51 jurnal dari Google Scholar, dan setelah duplikasi dihilangkan didapat 49 artikel untuk diulas.   1,8-Sineol bermanfaat untuk: a) anti inflamasi saluran nafas, b) anti inflamasi, c) anti mikroba, d) anti virus, e) anti kanker, f) anti spasmodik, g) analgesik, h) obat penenang, i) hipertensi, j) farmakokinetik. Uji in vitro maupun in vivo menunjukkan bahwa 1,8-sineol memiliki banyak manfaat terhadap kesehatan. Untuk memperkuatnya diperlukan uji klinik pada manusia agar dapat dimanfaatkan oleh masyarakat.

scholarly journals Riscos ao desenvolvimento fetal associados a depressão na gravidez: Uma breve revisão

2021 ◽  
Vol 10 (8) ◽  
pp. e49610817130
Author(s):  
Antonio Ycaro Rodrigues Lucena ◽  
Kassyo Lenno Sousa Dantas ◽  
Jusciellyson da Silva Nava ◽  
Mário Henrique de Souza Gomes Feitosa ◽  
Francis Aiala de Araújo Ferreira ◽  
...  
Keyword(s):  
Google Scholar

Objetivo: Observar as repercussões causadas pela depressão durante o período gestacional, em um contexto embrionário, apontando as principais alterações físicas, hormonais e psíquicas causadas pela depressão durante e após a gravidez ao feto. Metodologia: Foi realizado um levantamento bibliográfico de 30 publicações originais relevantes sobre o tema, utilizando os descritores: Depressão; Desenvolvimento Fetal e Embrionário; Gestação; Feto, nas bases de dados Scielo, Google Scholar e PUBMED. Foram utilizados critérios de inclusão e exclusão dos artigos, totalizando 23 publicações utilizadas para a redação do texto. Resultados e Discussão: A depressão (DP) grave é uma doença que afeta cerca de 300 milhões de pessoas em todo o mundo e, durante a gravidez, há a presença de efeitos psicobiológicos e fisiológicos sobre o corpo e mente feminina. Essas alterações, juntamente com o processo de depressão levam a uma condição psicopatológica que afeta diretamente o desenvolvimento da gravidez, detendo a capacidade de provocar alterações no desenvolvimento fetal, associada a riscos elevados para abortos espontâneos, partos prematuros e baixo peso ao nascer, além disso, mesmo após o nascimento, pode haver a presença de problemas comportamentais e emocionais a longo prazo. Considerações Finais: A depressão não tratada durante o período gestacional é associada a riscos para mãe e feto, podendo levar a quadros de aborto espontâneo ou parto prematuro e comprometimento do desenvolvimento fetal e problemas durante a vida adulta. Ressaltamos ainda a necessidade da realização de estudos em modelos de in vivo e in vitro para a disseminação de dados relativamente seguros.

scholarly journals Tinjauan Literatur: Uji In Vivo pada Antiviral Terpilih COVID-19

2020 ◽  
Vol 48 (4) ◽  
pp. 243-252
Author(s):  
Risqa Novita
Keyword(s):  
Animal Model ◽  
Literature Review ◽  
Google Scholar ◽  
World Health ◽  
Morbidity Rate ◽  
Corona Virus ◽  
In Vivo Testing ◽  
Health Organization

The novel corona virus, Severe Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) caused COVID-19 established by World Health Organization as global pandemic because it has spread globally and high mortality as above 8%. It needs an action to reduce the mortality rate and morbidity rate of COVID-19. There was no specific antiviral for COVID-19. We used antiviral based on our last experience against another infectious corona virus, MERS and SARS. Antiviral need safety and efficacy test. Antiviral test is start from in vitro, in vivo and clinical testing. Selecting antiviral for COVID-19 should pass through in vivo testing. The purpose of this review is to study which antiviral has passed the in vivo testing. Methods. A method of writing literature review from Google scholar and PubMed, with using keywords : antiviral, animal model and COVID-19. Results. Based on literature review, specific antiviral for COVID-19 has conducted on in vivo testing based on MERS and SARS experience, not for SARS-CoV-2 yet. The antivirals are Remdesivir, Lopinavir, Favipiravir dan Klorokuin Keywords: antiviral, animal model, COVID-19, SARS-CoV-2 Abstrak Virus novel korona yaitu Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Adalah penyebab COVID-19 yang telah ditetapkan oleh WHO sebagai pandemi global karena telah menyebar mendunia dan menyebabkan kematian cukup tinggi di atas 8%. Tindakan pengendalian yang efektif dibutuhkan untuk menekan angka kematian, salah satunya adalah pemberian antiviral. Hingga saat ini belum ada antiviral khusus untuk COVID-19. Antiviral yang digunakan berdasarkan pengalaman terhadap infeksi korona sebelumnya. Pemilihan antiviral yang efektif dan aman sangat diperlukan. Tahapan uji antivial seyogyanya dimulai dari uji in vitro, in vivo dan klinis. Antiviral yang dipilih untuk penderita COVID-19 sebaiknya sudah melalui tahapan in vivo, yaitu di hewan coba. Tulisan penulisan ini untuk mengkaji antiviral untuk COVID-19 yang telah melewati tahapan uji praklinis di hewan coba Metode. Metode tulisan ini berupa kajian dari literatur-literatur yang ada di Google scholar dan Pubmed, dengan pencarian menggunakan kata kunci antiviral, COVID-19 dan hewan model Hasil. Berdasarkan hasil dari penelusuran literatur, didapatkan data bahwa antiviral spesifik yang digunakan untuk penderita COVID-19 yang telah melalui tahapan di hewan model adalah Remdesivir, Lopinavir, Favipiravir dan Klorokuin, namun antiviral tersebut baru diuji terhadap MERS dan SARS, belum terhadap virus SARS-CoV-2. Kata kunci: antiviral, COVID-19, hewan model, SARS-CoV-2

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