Cell Type-Specific Intervention of Transforming Growth Factor β/Smad Signaling Suppresses Collagen Gene Expression and Hepatic Fibrosis in Mice

2005 ◽  
Vol 129 (1) ◽  
pp. 259-268 ◽  
Author(s):  
Yutaka Inagaki ◽  
Miwa Kushida ◽  
Kiyoshi Higashi ◽  
Johbu Itoh ◽  
Reiichi Higashiyama ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Hepatic Fibrosis ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Collagen Gene ◽  
Specific Intervention ◽  
Cell Type ◽  
Smad Signaling ◽  
Cell Type Specific

scholarly journals The Early-Immediate GeneEGR-1Is Induced by Transforming Growth Factor-β and Mediates Stimulation of Collagen Gene Expression

2006 ◽  
Vol 281 (30) ◽  
pp. 21183-21197 ◽  
Author(s):  
Shu-Jen Chen ◽  
Hongyan Ning ◽  
Wataru Ishida ◽  
Snezna Sodin-Semrl ◽  
Shinsuke Takagawa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Collagen Gene ◽  
Collagen Gene Expression ◽  
Stimulation Of

scholarly journals Transforming Growth Factor-β: A Multifunctional Regulator of Cancer Immunity

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3099
Author(s):  
Vivian Weiwen Xue ◽  
Jeff Yat-Fai Chung ◽  
Cristina Alexandra García Córdoba ◽  
Alvin Ho-Kwan Cheung ◽  
Wei Kang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cancer Progression ◽  
Transforming Growth Factor ◽  
Molecular Level ◽  
Transforming Growth Factor Β ◽  
Tumour Microenvironment ◽  
Cell Type ◽  
Cancer Immunity ◽  
Canonical Pathways ◽  
Cell Type Specific

Transforming growth factor-β (TGF-β) was originally identified as an anti-tumour cytokine. However, there is increasing evidence that it has important roles in the tumour microenvironment (TME) in facilitating cancer progression. TGF-β actively shapes the TME via modulating the host immunity. These actions are highly cell-type specific and complicated, involving both canonical and non-canonical pathways. In this review, we systemically update how TGF-β signalling acts as a checkpoint regulator for cancer immunomodulation. A better appreciation of the underlying pathogenic mechanisms at the molecular level can lead to the discovery of novel and more effective therapeutic strategies for cancer.

scholarly journals SnoN Is a Cell Type-specific Mediator of Transforming Growth Factor-β Responses

2005 ◽  
Vol 280 (13) ◽  
pp. 13037-13046 ◽  
Author(s):  
Krishna P. Sarker ◽  
Sylvia M. Wilson ◽  
Shirin Bonni
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Cell Type ◽  
A Cell ◽  
Cell Type Specific
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