Hyperhomocysteinemia and related factors in 600 hospitalized elderly subjects

Metabolism ◽  
2001 ◽  
Vol 50 (12) ◽  
pp. 1466-1471 ◽  
Author(s):  
Paolo Ventura ◽  
Rossana Panini ◽  
Chiara Verlato ◽  
Gabriella Scarpetta ◽  
Gianfranco Salvioli
Keyword(s):  
Elderly Subjects ◽  
Related Factors ◽  
Hospitalized Elderly

scholarly journals Examination of gait characteristics and related factors in elderly subjects with and without hallux valgus

2021 ◽  
Vol 6 (0) ◽  
pp. n/a
Author(s):  
Takaki Yoshida ◽  
Yoshitsugu Tanino ◽  
Tetsuya Nakao ◽  
Wataru Yamazaki ◽  
Toshiaki Suzuki
Keyword(s):  
Hallux Valgus ◽  
Elderly Subjects ◽  
Related Factors ◽  
Gait Characteristics

scholarly journals Microbiota in Clostridioides difficile-Associated Diarrhea: Comparison in Recurrent and Non-Recurrent Infections

Biomedicines ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 335 ◽  
Author(s):  
Alessandra Gazzola ◽  
Simona Panelli ◽  
Marta Corbella ◽  
Cristina Merla ◽  
Francesco Comandatore ◽  
...  
Keyword(s):  
Fecal Microbiota ◽  
Taxonomic Composition ◽  
Health Concern ◽  
Global Public Health ◽  
Related Factors ◽  
Clostridioides Difficile ◽  
Hospitalized Elderly ◽  
Clinical Presentations ◽  
Clostridioides Difficile Infection

Clostridioides difficile infection (CDI) is the leading cause of antibiotic-associated diarrhea, especially in hospitalized elderly patients, representing a global public health concern. Clinical presentations vary from mild diarrhea to severe pseudomembranous colitis that may progress to toxic megacolon or intestinal perforation. Antibiotic therapy is recognized as a risk factor and exacerbates dysbiosis of the intestinal microbiota, whose role in CDI is increasingly acknowledged. A clinically challenging complication is the development of recurrent disease (rCDI). In this study, using amplicon metagenomics, we compared the fecal microbiota of CDI and rCDI patients (sampled at initial and recurrent episode) and of non-infected controls. We also investigated whether CDI severity relates to specific microbiota compositions. rCDI patients showed a significantly decreased bacterial diversity as compared to controls (p < 0.01). The taxonomic composition presented significant shifts: both CDI and rCDI patients displayed significantly increased frequencies of Firmicutes, Peptostreptococcaceae, Clostridium XI, Clostridium XVIII, and Enterococcaceae. Porphyromonadaceae and, within it, Parabacteroides displayed opposite behaviors in CDI and rCDI, appearing discriminant between the two. Finally, the second episode of rCDI was characterized by significant shifts of unclassified Clostridiales, Escherichia/Shigella and Veillonella. No peculiar taxa composition correlated with the severity of infection, likely reflecting the role of host-related factors in determining severity.

scholarly journals Survival Analysis of Hospitalized Elderly People with Fractures in Brazil Over One Year

Geriatrics ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. 10
Author(s):  
Brenda Kelly Gonçalves Nunes ◽  
Brunna Rodrigues de Lima ◽  
Lara Cristina da Cunha Guimarães ◽  
Rafael Alves Guimarães ◽  
Claci Fátima Weirich Rosso ◽  
...  
Keyword(s):  
Elderly People ◽  
Cox Regression ◽  
Age Groups ◽  
The Elderly ◽  
Diabetic Patients ◽  
Related Factors ◽  
Hospitalized Elderly ◽  
Study Results ◽  
One Year ◽  
The Impact

Objective: This study analyzes the causes of death, survival, and other related factors in hospitalized elderly people with fractures over the course of one year. Methods: We followed 376 fracture patients for one year in a prospective cohort study to a reference hospital in central Brazil. The Cox regression model was used to analyze factors associated with survival. Results: The results indicate that the one-year mortality rate was high (22.9%). The independent factors linked to lower overall survival were as follows: patients aged ≥80 years with previous intensive care unit (ICU) admission and presence of comorbidities (diabetes mellitus [DM] and dementia). Conclusion: Our study results may contribute to a better understanding of the impact of fractures on the elderly population and reinforce the need to oversee age-groups, diabetic patients, and patients with complications during hospitalization.

scholarly journals Hospitalization Effects on Physical Performance and Muscle Strength in Hospitalized Elderly Subjects

2017 ◽  
Vol 06 (02) ◽  
Author(s):  
Andrea P Rossi ◽  
Sofia Rubele ◽  
Luca Pelizzari ◽  
Francesco Fantin ◽  
Susanna Morgante ◽  
...  
Keyword(s):  
Muscle Strength ◽  
Physical Performance ◽  
Elderly Subjects ◽  
Hospitalized Elderly

scholarly journals Cognitive impairment and malnutrition, predictors of all-cause mortality in hospitalized elderly subjects with cardiovascular disease

2013 ◽  
Vol 106 (4) ◽  
pp. 188-195 ◽  
Author(s):  
Karim Farid ◽  
Yi Zhang ◽  
Delphine Bachelier ◽  
Pascaline Gilson ◽  
Antonio Teixeira ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cognitive Impairment ◽  
Elderly Subjects ◽  
Hospitalized Elderly ◽  
All Cause Mortality

scholarly journals Pharmacokinetic Considerations in Geriatric Medication

2021 ◽  
pp. 332-341
Author(s):  
Priyanka Joshi ◽  
Naveen Sharma ◽  
Megha Jain ◽  
Harsha Matoli ◽  
Vinay Jain
Keyword(s):  
Old Age ◽  
Water Soluble ◽  
Elderly Subjects ◽  
Metabolic Clearance ◽  
Related Factors ◽  
Age Related ◽  
First Pass Metabolism ◽  
First Pass ◽  
The Impact ◽  
Pass Metabolism

Aging have an impact on the pharmacokinetic and pharmacodynamic characteristics of drugs, resulting in clinically relevant safety and efficacy consequences. There appear to be a rise in gastrointestinal (GI) problems with age, and certain slight variations in the GI tract have been noted. Nevertheless, insufficient studies have been done on the impact of aging on the expression and activity of these GI transporters. Aging is associated with some reduction in first-pass metabolism that might be due to a decrease in liver mass and perfusion. Some medications with considerable first-pass metabolism, can have markedly enhanced bioavailability and, as a consequence bioavailability. Other high clearance (CL) medications have identical bioavailability in both young and old individuals. However, at the other hand, the first-pass activation of some prodrugs, may be slowed or decreased, leading to a reduction in bioavailability. Some drugs may have a low bioavailability when taken orally, benefitted from transdermal administration. There are still no specific age-related liver ailments, routine clinical tests of liver function do not vary substantially with age, the course, and outcome of some liver diseases can be affected by age. The characteristic of high or low extraction of a drug by the liver has been attributed to whether the metabolic clearance (CL) of a drug falls or remains unchanged with age. Reduction in renal function in elderly subjects, particularly glomerular filtration rate, affects the clearance of many drugs such as water-soluble antibiotics and nonsteroidal anti-inflammatory drugs. The therapeutic significance of these declines in renal excretion is governed by the drug's expected toxicity. Many drugs show their effects specially in old age patients in different manner and depend on age related factors. It must take appropriate precautions for administering of different drugs to the old age patients.

scholarly journals Trends in mortality of alcoholic liver disease among adults in the United States, 1999-2017

2020 ◽  
Author(s):  
Emily Ryu ◽  
Harry H. Xia ◽  
Grace L Guo ◽  
Lanjing Zhang
Keyword(s):  
United States ◽  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
The United States ◽  
Elderly Subjects ◽  
Mortality Data ◽  
Research Database ◽  
Online Data ◽  
Related Factors ◽  
Alcoholic Fatty Liver

AbstractSome subtypes of alcoholic liver disease (ALD) recently had increasing prevalence or mortality. Prevalence of alcoholic fatty liver disease was increased. Mortality of alcoholic hepatitis and cirrhosis also had upward trends. However, trends in ALD- mortality and related factors are unclear. We therefore examined trends in age-standardized ALD-mortality among U.S. adults by factors using multivariable piecewise log-linear models. We collected mortality-data (age-standardized for the 2000 U.S. standard population) from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research database (CDC WONDER), using the Multiple Cause of Death Data to identify all ALD deaths in the United States for 1999-2017. We identified 296,194 deaths of ALD during 1999-2017. Trends in multivariable-adjusted, age-standardized mortality did not differ by sex, race, age or urbanization. The age-standardized mortality ratios of male/female, White/non-White and Metropolitan/Non-Metropolitan were 2.346, 1.657 and 0.851 in 2017, respectively. Strikingly, our multivariable model showed that subjects of 65+ years had the highest and the fastest growing mortality in the 3 age-groups. These findings highlight the continuation of health disparities in ALD, particularly in elderly subjects. Further works are warranted to validate and delineate the associated factors.

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