scholarly journals A Review of the Phytochemistry, Traditional Uses, and Biological Activities of the Genus Ballota and Otostegia

Planta Medica ◽  
2019 ◽  
Vol 85 (11/12) ◽  
pp. 869-910
Author(s):  
Sergio Rosselli ◽  
Gianfranco Fontana ◽  
Maurizio Bruno

AbstractThe 2 genera Ballota and Otostegia, belonging to the Lamiaceae family, are closely related taxonomically and found mainly in the Mediterranean area, Middle East, and North Africa. Since ancient times, they have been largely employed in traditional medicine for their biological properties such as antimicrobial, anti-inflammatory, antispasmodic, insecticidal, anti-malaria, etc. Phytochemical investigations of Ballota and Otostegia species have revealed that diterpenoids are the main constituents of the genera. A large number of flavonoids and other metabolites were also identified. This review, covering literature from 1911 up to 2018, includes traditional uses, chemical profiles (both of volatile and nonvolatile metabolites), and biological properties of all the taxa of these 2 genera studied to date.

Planta Medica ◽  
2018 ◽  
Vol 84 (09/10) ◽  
pp. 627-637 ◽  
Author(s):  
Rosa Tundis ◽  
Monica Loizzo

AbstractThe genus Santolina is a taxonomically complex group of plant species widely distributed in the Mediterranean flora and used in traditional medicine since ancient times for their biological properties, including antimicrobial, anti-inflammatory, antispasmodic, digestive, and analgesic activities. Phytochemical investigations of Santolina species have revealed the presence of terpenoids as the main bioactive constituents of the genus. Coumarins and flavonoids were also identified. This review deals, for the first time, with information on the traditional uses, chemical profile, and biological properties of plants of the genus Santolina in order to provide input for future research prospects.


Planta Medica ◽  
2020 ◽  
Author(s):  
Rossella Gagliano Candela ◽  
Sergio Rosselli ◽  
Maurizio Bruno ◽  
Gianfranco Fontana

AbstractThe genus Teucrium is a large and polymorphic genus of the Lamiaceae family distributed in mild climate zones, particularly in the Mediterranean basin and Central Asia. Studies of nonvolatile constituents of Teucrium species showed that they are a rich source of neo-clerodane diterpenoids, considered as chemotaxonomic markers of the genus. In addition to the nonvolatile metabolites, there has been a large interest in the essential oils of this genus. In this review, a complete survey of the chemical composition and biological properties of the essential oils isolated from Teucrium taxa is provided. In traditional medicine, since ancient times, species of this genus have been widely implemented for their biological properties, including antimicrobial, anti-inflammatory, antispasmodic, insecticidal, anti-malaria, etc. Therefore, a complete review of all of the traditional uses of Teucrium taxa are also reported.


2019 ◽  
Vol 70 (3) ◽  
pp. 135-146 ◽  
Author(s):  
Eddie John ◽  
Richard I. Vane-Wright

We report a recent observation of D. c. chrysippus f. 'alcippus' in Cyprus, a variant of the Plain Tiger or African Queen butterfly infrequently seen in the Mediterranean, especially in the east of the region. D. c. chrysippus f. 'alcippus' appears to have been recorded from Cyprus on just one previous occasion, by R. E. Ellison, in 1939. However, a specimen of the similar f. 'alcippoides' collected by D. M. A. Bate in Cyprus in 1901 could perhaps be the source of Ellison's otherwise undocumented claim. These records are assessed in relation to the known distributions of the various forms of D. chrysippus across the Mediterranean, North Africa and Middle East, and more briefly with respect to the vast range of this butterfly across much of the Old World tropics and subtropics. The ambiguity and potential confusion caused by using an available name to designate both a geographically circumscribed subspecies or semispecies, and a genetically controlled phenotype that can be found far beyond the range of the putative subspecies or semispecies, is also discussed.


2021 ◽  
Vol 3 (2) ◽  
Author(s):  
Ilias Marmouzi ◽  
Shahira M. Ezzat ◽  
Eman Sherien Mostafa ◽  
Meryem El Jemli ◽  
Rasha Ali Radwan ◽  
...  

AbstractDespite the richness and biodiversity of invertebrates and algae in the Mediterranean Sea, these organisms are still poorly studied. The objective of our research is the discovery of bioactive lead compounds from the Mediterranean Sea sponge Hemimycale Collumella (HC). HC sponge (189.0 g) was collected from Mdiq costs on the Mediterranean Sea and extracted with methanol to yield (10 g) which was then subjected to fractionation. A bio-guided protocol was applied through evaluation of 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging and Oxygen Radical Absorbance Capacity (ORAC), α-amylase, β-glucosidase, pancreatic lipase inhibition as well as anti-collagenase, anti-elastase, antityrosinase and cytotoxic activity. 2,3-O-Hexahydroxydiphenoyl-(α/β)-glucose (1) and gentisic acid 2-O-β-glucoside (2) were isolated from the water fraction, quercetin-3-O-β-glucopyranoside (3), kaempferol 3-O-β-glucopyranoside (4) and isorhamnetin 3-O-β-glucopyranoside (5) from n-butanol fraction, gallic acid (6) from ethyl acetate fraction and gallic acid-3-methyl ether (7) from methylene chloride fraction. Compound 5 had the highest DPPH and ORAC activity. Compounds 1–5 had promising lipase inhibition activities which exceeded that of the standard Orlistat, while compounds 1–7 showed anti-tyrosinase activity higher than that of the standard Hydroquinone monomethyl ether. This is the first report for evaluation of the biological activities of 2, 3-O-hexahydroxydiphenoyl-(α/β)-glucose (1), gentisic acid 2-O-β-glucoside (2) and gallic acid-3-methyl ether (7).


Phytotaxa ◽  
2017 ◽  
Vol 297 (3) ◽  
pp. 221 ◽  
Author(s):  
CRISTIAN BRULLO ◽  
SALVATORE BRULLO ◽  
SALVATORE CAMBRIA ◽  
RIDHA EL MOKNI ◽  
MOHAMED HÉDI EL AOUNI ◽  
...  

Bituminaria tunetana a new species occurring in Tunisia is described and illustrated. It shows some relationships with B. basaltica from Aeolian Archipelago (Sicily), mainly for having very small flowers and also with B. flaccida from Middle East in having pale colored corolla and few-flowered inflorescences, but the three species differ among them in many diacritic features regarding the leaves, flowers, fruits and seeds. Besides, it is well distinct from B. bituminosa, species widely spread in Sicily and in several countries of the Mediterranean area, for many morphological features, as well as in micro-morphology of seed testa and pod indumentum. Its distribution, ecology and conservation status are also examined. An analytical key of the species belonging to Bituminaria subgen. Bituminaria is also provided.


Antibiotics ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 395
Author(s):  
Giulia Potente ◽  
Francesca Bonvicini ◽  
Giovanna Angela Gentilomi ◽  
Fabiana Antognoni

Extensive documentation is available on plant essential oils as a potential source of antimicrobials, including natural drugs against Candida spp. Yeasts of the genus Candida are responsible for various clinical manifestations, from mucocutaneous overgrowth to bloodstream infections, whose incidence and mortality rates are increasing because of the expanding population of immunocompromised patients. In the last decade, although C. albicans is still regarded as the most common species, epidemiological data reveal that the global distribution of Candida spp. has changed, and non-albicans species of Candida are being increasingly isolated worldwide. The present study aimed to review the anti-Candida activity of essential oils collected from 100 species of the Lamiaceae family growing in the Mediterranean area and the Middle East. An overview is given on the most promising essential oils and constituents inhibiting Candida spp. growth, with a particular focus for those natural products able to reduce the expression of virulence factors, such as yeast-hyphal transition and biofilm formation. Based on current knowledge on members of the Lamiaceae family, future recommendations to strengthen the value of these essential oils as antimicrobial agents include pathogen selection, with an extension towards the new emerging Candida spp. and toxicological screening, as it cannot be taken for granted that plant-derived products are void of potential toxic and/or carcinogenic properties.


2013 ◽  
Vol 20 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Sara Fregonese

This special issue of Euro-commentaries tackles the question of what links unprecedented anti-regime uprisings in the MENA (Middle East and North Africa) region, with the largest protests in decades in several European cities. Beyond the specificities of individual cases, uprisings on both sides of the Mediterranean have highlighted strong and often violent collisions between resistance movements and state security. How are these collisions reshaping urban and political geographies in the Mediterranean? The papers presented here explore different aspects of the 2011 protests, and share the view that these are shaped by concerns for social justice, human rights and democracy, which are not a prerogative of the Arab world, but indicate instead more complex geographies.


2020 ◽  
Author(s):  
Manfred A. Lange

<p>The region of the Middle East and North Africa (MENA region) encompasses countries of the eastern Mediterranean, the Middle East, and North Africa, from Morocco in the West to the Islamic Republic of Iran in the East and from the Syrian Arab Republic in the North to the Republic of Yemen in the South. It is home to some 500 million inhabitants and is characterized by widely varied political and economic settings and a rich cultural heritage. Stark environmental gradients, as well as significant differences in the provision of ecosystem services, both East to West and South to North, are typical for the MENA Region.</p><p>Climate changes in the Mediterranean Basin, in general, and in the MENA countries, in particular, currently exceed global mean values significantly. Numerical model results indicate that this trend will continue in the near future and imply that the number of extreme summer temperatures and heatwaves may increase significantly over the coming decades. At the same time, a decrease in precipitation and a significantly longer dry season for most MENA countries than at present are anticipated. This leads to a significantly increased demand for water and energy. In addition, other factors further exacerbate these demands in the MENA, including the general economic development, extreme population growth and increasing urbanization, changes in lifestyle, shifting consumption patterns, inefficiencies in the use of resources that result from technical and managerial inadequacies and energy and water subsidies in several countries of the region to name but a few.</p><p>The impacts of climate change will be particularly severe in urban settings and large cities of the Mediterranean Basin and the MENA region. Cities will see an enhanced heat accumulation compared to the surrounding rural land due to heat-build-up in buildings, transportation infrastructure, and enhanced human activities. Reduced ventilation within cities exacerbates the warming, particularly during summer heatwaves. Consequently, additional, energy-intensive space cooling will be needed in order to maintain acceptable indoor conditions. With regard to water scarcity, the aforementioned decreases in precipitation will reduce available drinking water for city inhabitants and green spaces. This requires the provision of unconventional water sources, e.g., through desalination, which requires significant quantities of energy. Overall, climate change will exacerbate resource demand for water and energy, in general, and in urban settings, in particular.</p><p>However, the provision of water and energy are interrelated. In order to maintain water and energy security in the MENA region, these issues need therefore be considered holistically in the framework of the Water-Energy-Nexus (WEN).</p><p>The present paper aims to elucidate some of the interrelationships between water and energy resources and their provision and will briefly outline a few of the possible mitigation/adaptation options/strategies to reduce adverse impacts of climate change on the MENA region and its inhabitants.</p>


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