Network Oncolgy Specialist Advisory Service – A Survey of the Psychosocial Situation of Long Term Cancer Survivors During Childhood or Adolescents

Abstract Background The number of long term cancer survivors during childhood or adolescence is increasing steadily. Survivors often suffer from physical or psychosocial long term effects. There is currently little data on the arrangement of long term aftercare in the field of psychosocial care. Methods In November 2017 a questionnaire was sent to 1900 cancer survivors aged between 18 and 35 years whose diagnosis dated at least five years prior. The obtained data serve as a condition and needs assessment, how the (psychosocial) long-term aftercare is perceived by the survivors and what else is desired. The analysis was conducted using descriptive statistics as well as the calculation of bivariate correlations. Results The response rate was 54.9% (n=1.043). The median interval from the first diagnosis was 20 years. In total 666 survivors (63.9%) stated that they suffered from at least one long term effect. Within this, especially neurocognitive themes played a role. 87.2% of the respondents had the feeling that they had overcome the illness/therapy well. Conclusion Through a stronger patient-focussed orientation concerning the current care and advisory services, the situation of long term survivors could be improved. This especially includes access to relevant information that focuses on the available psychosocial and welfare services, as well as to advisory and care services. Additionally, the development and expansion of care structures in the areas of neurocognition and psychotherapy is important to ensure long term participation attendance.

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Long-Term Effect of Anticancer Therapy on Dentition in Childhood Cancer Survivors: An Observational, Cross-Sectional Study

The Indian Journal of Pediatrics ◽

10.1007/s12098-021-03818-1 ◽

2021 ◽

Author(s):

Mohammad Atif ◽

Vijay Prakash Mathur ◽

Nitesh Tewari ◽

Kalpana Bansal ◽

Morankar Rahul ◽

...

Keyword(s):

Cancer Survivors ◽

Childhood Cancer ◽

Childhood Cancer Survivors ◽

Anticancer Therapy ◽

Cross Sectional Study ◽

Term Effect ◽

Sectional Study ◽

Cross Sectional ◽

Long Term Effect

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Long-Term Effect of Interferon on Keratinocytes That Maintain Human Papillomavirus Type 31

Journal of Virology ◽

10.1128/jvi.76.17.8864-8874.2002 ◽

2002 ◽

Vol 76 (17) ◽

pp. 8864-8874 ◽

Cited By ~ 41

Author(s):

Yijan E. Chang ◽

Loren Pena ◽

Ganes C. Sen ◽

Jung K. Park ◽

Laimonis A. Laimins

Keyword(s):

Human Papillomavirus ◽

Morphological Characteristics ◽

Human Keratinocytes ◽

Inducible Promoter ◽

Interferon Treatment ◽

Long Term Effects ◽

Long Term Effect ◽

High Doses ◽

Rates Of Growth

ABSTRACT The long-term effects of interferon treatment on cell lines that maintain human papillomavirus type 31 (HPV-31) episomes have been examined. High doses and prolonged interferon treatment resulted in growth arrest of HPV-positive cells, with a high percentage of cells undergoing apoptosis. These effects were not seen with interferon treatment of either normal human keratinocytes or cells derived from HPV-negative squamous carcinomas, which exhibited only slight decreases in their rates of growth. Within 2 weeks of the initiation of treatment, a population of HPV-31-positive cells that were resistant to interferon appeared consistently and reproducibly. The resistant cells had growth and morphological characteristics similar to those of untreated cells. Long-term interferon treatment of HPV-positive cells also resulted in a reduction in HPV episome levels but did not significantly decrease the number of integrated copies of HPV. Cells that maintained HPV genomes lacking E5 were sensitive to interferon, while cells expressing only the E6/E7 genes were resistant. In contrast, cells that expressed E2 from a tetracycline-inducible promoter were found to be significantly more sensitive to interferon treatment than parental cells. This suggests that at least a portion of the sensitivity to interferon could be mediated through the E2 protein. These studies indicate that cells maintaining HPV episomes are highly sensitive to interferon treatment but that resistant populations arise quickly.

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Nutritional deficiencies and later behavioural development

Proceedings of The Nutrition Society ◽

10.1017/s0029665100000069 ◽

2000 ◽

Vol 59 (1) ◽

pp. 47-54 ◽

Cited By ~ 54

Author(s):

S. M. Grantham-McGregor ◽

S. P. Walker ◽

S. Chang

Keyword(s):

Cultural Context ◽

School Achievement ◽

Protein Energy Malnutrition ◽

Term Effect ◽

Nutritional Deficiencies ◽

Long Term Effects ◽

Protein Energy ◽

Long Term Effect ◽

Long Term Follow Up

The literature on the long-term effects of nutritional deficiencies in early life is reviewed. The severity and duration of the deficiency, the stage of the children’s development, the biological condition of the children and the socio-cultural context may all modify the effect. There is substantial evidence that reduced breast-feeding, small-for-gestational-age birth weight, Fe and I deficiency, and protein-energy malnutrition (PEM) are associated with long-term deficits in cognition and school achievement. However, all these conditions are associated with poverty and poor health, which may account for the association. It is difficult to establish that the long-term relationship is causal, as it requires a randomized treatment trial with long-term follow-up. Such studies are only available for I deficiency in utero and early childhood PEM. Results from these studies indicate that I deficiency has a long-term effect and PEM probably has a long-term effect.

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Introduction

Intelligent Assistive Technologies for Dementia ◽

10.1093/med/9780190459802.003.0001 ◽

2019 ◽

pp. 1-12

Author(s):

Fabrice Jotterand ◽

Marcello Ienca ◽

Tenzin Wangmo ◽

Bernice S. Elger

Keyword(s):

Older Adults ◽

Financial Management ◽

Health Care Services ◽

Assistive Technologies ◽

Long Term Effects ◽

Care Services ◽

Regulatory Frameworks ◽

Legal Challenges ◽

Specialized Care

Dementia and especially Alzheimer’s disease (AD) are among the most expensive and burdensome diseases in Western societies. It is estimated that the number of older adults being diagnosed and living with dementia reached 35.6 million worldwide in 2010 and it is expected to increase up to 135.5 million in 2050. The increased incidence of the disease poses a major challenge for public health systems and health care services in terms of financial management and provision of specialized care to this patient population. The development and implementation of smart assistive tools (Intelligent Assistive Technologies - IATs) to compensate for the specific physical and cognitive deficits of older adults with dementia have been recognized by many as one of the most promising approaches to this emerging financial and caregiving burden. This volume aims at providing an up-to-date overview of the current state of the art of IATs for dementia care, determining their current taxonomy, and defining their functionality, capability, and level of implementation. In addition, this collection of essays examines the implications of the use of IATs at the medical level, including psychological and clinical issues and the ethical and legal challenges such as problems related to their long-term effects (psychological and physiological), questions related to privacy, and the values and norms guiding the development of regulatory frameworks at the national and international stage.

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Long-term effects of cancer on families of adult cancer survivors.

Handbook of cancer control and behavioral science: A resource for researchers, practitioners, and policymakers. ◽

10.1037/14499-026 ◽

2009 ◽

pp. 467-485

Author(s):

Laurel L. Northouse ◽

Suzanne Mellon ◽

Janet Harden ◽

Ann Schafenacker

Keyword(s):

Cancer Survivors ◽

Long Term Effects ◽

Adult Cancer Survivors

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Brassinosteroid-induced de-etiolation of Arabidopsis thaliana seedlings resembles the long-term effects of cytokinins

Functional Plant Biology ◽

10.1071/pp98010 ◽

1998 ◽

Vol 25 (6) ◽

pp. 719 ◽

Cited By ~ 2

Author(s):

Jie Luo ◽

Ji-Chu Chen ◽

Yu-Ju Zhao

Keyword(s):

Arabidopsis Thaliana ◽

Term Effect ◽

Hypocotyl Elongation ◽

Long Term Effects ◽

Short Term ◽

Expression Of Genes ◽

Long Term Effect ◽

In The Wild ◽

Positive Regulators

Cytokinins can cause de-etiolation of Arabidopsis thaliana (L.) Heynh. seedlings growing in the dark. Brassinosteroids (BRs) have been considered to regulate negatively the de-etiolation in dark-grown Arabidopsis seedlings. We show here that epi-brassinolide (epi-BL) can partially produce the phenotype of de-etiolation as caused by treatment with cytokinins in the dark, including the development of leaves and epicotyls in the wild-type and the BR-deficient mutant det2. But BRs cannot inhibit hypocotyl elongation, nor restore all the inhibition caused by cytokinins and light. We have found that there are distinct short term and long term phases of induction of de-etiolation by cytokinins. The short-term effect is probably coupled to ethylene in the inhibition of the hypocotyl elongation; the long-term effect causes morphogenesis of leaves and epicotyls. BRs can only regulate de-etiolation in the long term. We propose that the inhibition of hypocotyl elongation of det2 in darkness is caused by the absence of BR-dependent elongation rather than the inhibition caused by the expression of genes for photomorphogenesis. We propose that BRs resemble cytokinins in regulating de-etiolation as positive regulators, and that the inhibition of hypocotyl elongation and the development of leaves and epicotyls in de-etiolation are independent processes.

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Longitudinal Follow-Up of Long-Term Care Planning Using PlanYourLifespan.org

Journal of Applied Gerontology ◽

10.1177/0733464820943066 ◽

2020 ◽

pp. 073346482094306

Author(s):

Vanessa Ramirez-Zohfeld ◽

Anne Seltzer ◽

Ana Ramirez ◽

Ruqayyah Muhammad ◽

Lee A. Lindquist

Keyword(s):

Older Adults ◽

Long Term Care ◽

Long Term Effects ◽

Care Needs ◽

Term Care ◽

User Perceptions ◽

Care Plans ◽

Age In Place ◽

Care Services

Many older adults wish to age-in-place but do not have long-term care plans for when they may require more assistance. PlanYourLifespan.org (PYL) is an evidence-based tool that helps older adults understand and plan for their long-term care needs. We examined the long-term effects of PYL use on user perceptions and planning of long-term care services. Individuals who previously accessed PYL were invited to complete an online, nation-wide mixed methodology survey about end-user outcomes related to PYL. Among 115 completed surveys, users found PYL helpful with long-term planning for their future needs. Over half of website users reported having conversations with others because of PYL use. However, 40% of respondents reported not having a conversation with others about their plans; common themes for barriers to planning included procrastination and a lack of immediate support needs. Although PYL helps with planning, many people are still not communicating their long-term care plans.

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Long-term regulation of hexose uptake by isoproterenol in cultured 3T3 adipocytes

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1985.248.6.e706 ◽

1985 ◽

Vol 248 (6) ◽

pp. E706-E711 ◽

Cited By ~ 2

Author(s):

J. P. van Putten ◽

H. M. Krans

Keyword(s):

Protein Synthesis ◽

Prolonged Exposure ◽

Term Effect ◽

Long Term Effects ◽

Fat Cell ◽

Short Term ◽

Long Term Effect ◽

Short Term Exposure ◽

Hexose Uptake

Catecholamines are known to have short-term regulatory effects on fat cell hexose uptake. We examined the long-term effects of catecholamines on the insulin-sensitive 2-deoxyglucose (dGlc) uptake in cultured 3T3-L1 adipocytes. Prolonged exposure (48 h) to isoproterenol (beta-adrenergic agonist) stimulated the basal dGlc uptake up to 90%. The effect was specific, time, concentration, and protein synthesis dependent and reversible. The effect of insulin was unaltered and superimposed on the increase in basal dGlc uptake. The long-term effect of isoproterenol was mimicked by epinephrine, dibutyryl cAMP (DBcAMP), and 1-methyl-3-isobutylxanthine (IBMX). By contrast, short-term exposure to isoproterenol (and epinephrine) induced a protein synthesis-independent increase in basal dGlc uptake (30%) not accompanied by an increase in insulin responsiveness. Moreover, on short-term basis, DBcAMP and IBMX suppressed both the basal and insulin-stimulated uptake up to 50%. Determination of the intracellular nonphosphorylated dGlc during the uptake and of the hexokinase activity revealed that the long-term effect of isoproterenol was most likely due to alterations low in dGlc transport. In conclusion, long-term regulators of hexose uptake are in cultured 3T3-L1 adipocytes, isoproterenol, and other cAMP stimulators. The long-term effect is independent from the short-term regulatory effect of the agents and from the effect of insulin.

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