4 Day 3: Wet-Laboratory Microsurgical Training: Basic Principles for Working with Laboratory Animals

2020 ◽  
Keyword(s):  
Laboratory Animals ◽  
Basic Principles

Actual issues of hygienic regulation and creation of safe working conditions at pharmaceutical manufacturing enterprises

2020 ◽  
Vol 60 (10) ◽  
pp. 640-644
Author(s):  
Vadim M. Vasilkevich ◽  
Ruslan V. Bogdanov ◽  
Elena V. Drozdova
Keyword(s):  
Pharmaceutical Industry ◽  
Working Conditions ◽  
Experimental Studies ◽  
Pharmaceutical Products ◽  
Laboratory Animals ◽  
Production Environment ◽  
Basic Principles ◽  
Toxicological Studies ◽  
Health Disorders ◽  
Safe Working

Introduction. The working conditions of pharmaceutical industry workers are characterized by the combined effect of unfavorable factors of the production environment, among which the leading one is chemical. The aim of study is to substantiate the basic principles and criteria for hygienic regulation of pharmaceutical products in their production to ensure safe working conditions for employees based on the results of their own research and existing requirements of technical regulations. Materials and methods. Analysis of working conditions and the prevalence of health disorders in pharmaceutical workers (according to literature data), toxicological studies of pharmaceutical substances on laboratory animals, scientific justification of hygiene standards in the air of the working area. Results. Among employees of the pharmaceutical industry, the predominant forms of production-related health disorders are diseases of the respiratory system, as well as skin dermatitis of allergic origin, liver and biliary tract diseases. Based on the results of experimental studies of domestic pharmaceutical products for the treatment of cardiovascular, oncological and mental diseases that have priority socio-economic significance, the basic principles and features of the practice of justifying the hygienic standards of medicines in the air of the working area are developed and systematized. Conclusions. During hygienic rationing of medicines, it is necessary to use a differentiated approach that allows, based on the analysis of information about the chemical structure, physical and chemical characteristics, production conditions, pharmacotherapeutic activity, and the results of studying the toxic effect in an experiment on laboratory animals, to determine the maximum permissible content in the air of the working area of medicines or to justify the prohibition of isolation with reasoned recommendations for their safe production.

scholarly journals BASIC PRINCIPLES AND METHODS OF MODELING HYPOGONADISM: A LITERATURE REVIEW

2020 ◽  
Vol 10 (4) ◽  
pp. 56-62
Author(s):  
Antonina Pronina ◽  
Galina Suvorova ◽  
Aleksey Chaulin ◽  
Julia Grigoryeva ◽  
Dmitry Rusakov ◽  
...  
Keyword(s):  
Pathological Condition ◽  
Research Area ◽  
Experimental Models ◽  
Laboratory Animals ◽  
Basic Principles ◽  
Domestic Literature ◽  
Beneficial Effects ◽  
Advantages And Disadvantages ◽  
Genes Encoding ◽  
Distal Section

Purpose: To consider the basic principles and methods of experimental modeling of hypogonadism in laboratory animals, to define the main benefits and drawbacks of each separate method in hypogonadism modeling. Materials and methods: We analyzed modern foreign and domestic literature using the following databases: PubMed / Medline, Embase, Google Scholar. Results: Presently, there are three main principles of modeling hypogonadism: surgical, genetic, and pharmacological. The principle of surgical modeling of hypogonadism is based on the removal of the gonads, or on the temporary imposition of a suture on the distal section of the spermatic cord, which leads to occlusion of the testicular artery that feeds the gonads. The principle of genetic modeling of hypogonadism is to induce mutations in the genes encoding the most important regulatory molecules, in particular kisspeptin, neurokinin B, and their receptors in laboratory animals. The principle of pharmacological modeling of hypogonadism is based on the administration of streptozocin to laboratory animals, which has a toxic effect on the gonads and pancreas. Conclusion: Hypogonadism represents a very common pathological condition that affects many organs and tissues. Therefore, the use of experimental models of hypogonadism to study fundamental pathophysiological and pathomorphological processes is a relevant research area. Each principle of hypogonadism modeling is unique in its own way, exhibits advantages and disadvantages, and allows the creation of specific conditions necessary for the development of hypogonadism in laboratory animals. Taking into account the numerous beneficial effects of testosterone on many cells and tissues of the human body, it becomes obvious that experimental models of hypogonadism can be in demand for many medical spheres.

Coming of Age

2019 ◽  
Author(s):  
Cheryl L. Sisk ◽  
Russell D. Romeo
Keyword(s):  
Coming Of Age ◽  
Laboratory Animals ◽  
Impulsive Behavior ◽  
Graduate Course ◽  
Basic Principles ◽  
Neural Underpinnings ◽  
Brain And Behavior ◽  
Upper Level ◽  
And Behavior ◽  
Adolescent Brain Development

The purpose of this book is to explore the neurobiology and psychobiology underlying puberty and adolescence. It tells the story of how contemporary neuroscience has come to make significant contributions to the understanding of a developmental period that used to be the sole purview of developmental psychologists and pediatric endocrinologists. The authors presume the reader will have a general understanding of the basic principles of neuroscience and psychology and have written this book to serve as an appropriate text for an upper-level undergraduate seminar or graduate course designed to probe puberty and adolescence more deeply from a psychobiological perspective. Topics covered in specific chapters include timing and regulation of reproductive maturation (puberty), mechanisms of adolescent brain development in laboratory animals and humans, neural underpinnings of higher risk-taking and impulsive behavior in adolescents, hormonal programming of social behaviors during adolescence, and effects of stress and drugs on the adolescent brain. The book ends with the authors’ perspective on some of the big questions about the adolescent brain and behavior that remain to be answered.

Current Issues: Evidence-Based Practice for the Real World: Thoughts on Clinical Education in Communication Disorders

2010 ◽  
Vol 20 (3) ◽  
pp. 100-105 ◽  
Author(s):  
Anne K. Bothe
Keyword(s):  
Clinical Education ◽  
Real World ◽  
Evidence Based Practice ◽  
Communication Disorders ◽  
University Faculty ◽  
Evidence Based ◽  
Speech Language Pathology ◽  
Basic Principles ◽  
The Real ◽  
Language Pathology

This article presents some streamlined and intentionally oversimplified ideas about educating future communication disorders professionals to use some of the most basic principles of evidence-based practice. Working from a popular five-step approach, modifications are suggested that may make the ideas more accessible, and therefore more useful, for university faculty, other supervisors, and future professionals in speech-language pathology, audiology, and related fields.

Basic Ideas and Principles for Quantifying Regional Blood Flow with Nuclear Medical Techniques

1996 ◽  
Vol 35 (05) ◽  
pp. 181-185 ◽  
Author(s):  
H. Herzog
Keyword(s):  
Blood Flow ◽  
Nuclear Medicine ◽  
Regional Blood Flow ◽  
Visual Presentation ◽  
Regional Cerebral Blood ◽  
Basic Principles ◽  
Parametric Images ◽  
Major Application ◽  
Basic Ideas ◽  
The Brain

SummaryThe measurement of blood flow in various organs and its visual presentation in parametric images is a major application in nuclear medicine. The purpose of this paper is to summarize the most important nuclear medicine procedures used to quantify regional blood flow. Starting with the first concepts introduced by Fick and later by Kety-Schmidt the basic principles of measuring global and regional cerebral blood are discussed and their relationships are explained. Different applications and modifications realized first in PET- and later in SPECT-studies of the brain and other organs are described. The permeability and the extraction of the different radiopharmaceuticals are considered. Finally some important instrumental implications are compared.

SARI : A User-Oriented Data Bank System for Medical Applications

1976 ◽  
Vol 15 (02) ◽  
pp. 69-74
Author(s):  
M. Goldberg ◽  
B. Doyon
Keyword(s):  
Data Base ◽  
Personal Data ◽  
Data Bank ◽  
Medical Applications ◽  
Basic Principles ◽  
Base Management ◽  
General Data ◽  
Privacy Problem ◽  
Bank System ◽  
Made In

This paper describes a general data base management package, devoted to medical applications. SARI is a user-oriented system, able to take into account applications very different by their nature, structure, size, operating procedures and general objectives, without any specific programming. It can be used in conversational mode by users with no previous knowledge of computers, such as physicians or medical clerks.As medical data are often personal data, the privacy problem is emphasized and a satisfactory solution implemented in SARI.The basic principles of the data base and program organization are described ; specific efforts have been made in order to increase compactness and to make maintenance easy.Several medical applications are now operational with SARI. The next steps will mainly consist in the implementation of highly sophisticated functions.

Christian unity: the search for ways to achieve

2001 ◽  
pp. 91-100
Author(s):  
Yu. Ye. Reshetnikov
Keyword(s):  
Catholic Church ◽  
Russian Orthodox ◽  
Orthodox Church ◽  
Turn Of The Millennium ◽  
Russian Orthodox Church ◽  
Basic Principles ◽  
Christian Churches ◽  
The Press ◽  
Christian Unity ◽  
Future Policy

Last year, the anniversary of all Christianity, witnessed a number of significant events caused by a new interest in understanding the problem of the unity of the Christian Church on the turn of the millennium. Due to the confidentiality of Ukraine, some of these events have or will have an immediate impact on Christianity in Ukraine and on the whole Ukrainian society as a whole. Undoubtedly, the main event, or more enlightened in the press, is a new impetus to the unification of the UOC-KP and the UAOC. But we would like to focus on two documents relating to the problem of Christian unity, the emergence of which was almost unnoticed by the wider public. But at the same time, these documents are too important as they outline the future policy of other Christian denominations by two influential Ukrainian christian churches - the Russian Orthodox Church and the Ukrainian Greek Catholic Church. These are the "Basic Principles of the attitude of the Russian Orthodox Church to the" I ", adopted by the Anniversary Bishops' Council of the Russian Orthodox Church, and the Concept of the Ecumenical Position of the Ukrainian Greek Catholic Church, adopted by the Synod of the Bishops of the UGCC. It is clear that the theme of the second document is wider, but at the same time, ecumenism, unification is impossible without solving the problem of relations with others, which makes it possible to compare the approaches laid down in the mentioned documents to the building of relations with other Christian confessions.

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